Results 201 to 210 of about 95,624 (263)

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Stability modification of therapeutic aptamers: from biostability bottlenecks to nuclease-resistant construct design. [PDF]

RSC Chem Biol
Pan Z, Pan Y, Zhang H, Chen Z, Zhang Y, Zhang B, Lu A, Zhang G, Yu S.   +8 more
europepmc   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Long-stranded XNA-cssDNA hybrids for robust data storage. [PDF]

Sci Adv
Sun X, Pei Y, Tan P, Bian T, Wang R, Wang Y, Xie J, Hong L, Song J.   +8 more
europepmc   +1 more source

Mock Samples That Mimic Human Cervicovaginal Samples to Accelerate the Development and Evaluation of Assays for High-Risk HPV for Cervical Cancer Screening. [PDF]

J Med Virol
Novak EN, Ma A, Hansen CJ, Wazir Z, Bond M, Scheurer ME, Guo M, Salcedo MP, Schmeler KM, Richards-Kortum RR.   +9 more
europepmc   +1 more source

Sequence-Encoded Frustration Directs the Formation of Abridged G-Quadruplex Architectures. [PDF]

Angew Chem Int Ed Engl
Qian Y, Ali MY, Karsisiotis AI, Dillon P, Dvorkin SA, McPherson PAC, Webba da Silva M.   +6 more
europepmc   +1 more source

Effects of Loop Nucleobase Substitution on G-Quadruplex Thermal Stability in Aqueous Glycine Betaine, Proline, TMAO, and Urea Solutions. [PDF]

Biomolecules
Schwinefus JJ, Corluka M, Dobrinski I, Jaeckle SL, Kim J, Knowlan G, Omodt H, Otto N, Reid MV, Rognerud R, Stein KM.   +10 more
europepmc   +1 more source

HMGB1 binds to and disrupts the hairpin structure of RNA15 and inhibits toll-like receptor activation. [PDF]

J Biol Chem
Lin C, Li P, Savitskaya AG, Lyukmanova E, Goncharuk SA, Mineev KS, Du X, Wang Y, Wang X.   +8 more
europepmc   +1 more source

Single-molecule magnetic tweezers reveal distinct dynamics and enhanced mechanical stability of ssDNA 31 and 52 knots. [PDF]

Nucleic Acids Res
Zhang Z, Zhang Y, Xue Z, Shang F, Liu Y, Le S, Chen H.   +6 more
europepmc   +1 more source