Results 221 to 230 of about 95,624 (263)

Single molecule approaches of nucleic acids conformational changes

Methods, 2019
Single molecule approaches of nucleic acids conformational changes One of the primordial questions today in biology is: how does DNA regulate its own metabolism? In other words, what are the mechanisms that enables specific genes to be transcribed while others are silenced?
Lavelle, Christophe, Tardin, Catherine
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Evolution of conformational principles in nucleic acids

International Journal of Quantum Chemistry, 2009
The analysis of conformations of nucleic acids and polynucleotides have been greatly simplified by the important observations that the nucleotide building blocks exhibit two classes of preferred conformations and that the flexibility in the polynucleotide chain resides mainly in the internucleotide PO linkages.
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Copper(II)-Nucleic acid interactions—A conformational study

Journal of Theoretical Biology, 1979
Abstract The effect of copper complexation upon the conformational angles in mononucleotides and dinucleotides was studied using classical potential energy expressions. The geometrical parameters were taken from crystallographic reports on the base-metal complexes.
J, Bandekar, B K, Sathyanarayana
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Nucleic acid analogs: Conformation and their functionalities

Die Makromolekulare Chemie, 1985
Poly-L-, -D-, and -DL-lysine derivatives having pendant nucleic acid bases were prepared by using a polymer modification reaction. Conformation of the polymers was studied by CD and ORD measurements, and the effects of pH of the system, as well as the solvents on the helicity of the polymers were investigated in detail.
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Alternative conformations of a nucleic acid four-way junction

Journal of Molecular Biology, 2000
A crystal structure of a 108 nucleotide RNA-DNA complex containing a four-way junction was solved at 3.1 A resolution. The structure of the junction differs substantially from the "stacked-X" conformation observed previously, due to a 135 degrees rotation of the branches.
J, Nowakowski, P J, Shim, C D, Stout, G F, Joyce   +3 more
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Conformational principles of nucleic acids

1981
From a conformational standpoint, nucleic acids are enormously complex. In order to rigorously describe, for example, the secondary structure of a repeating polynucleotide such as fibrous poly dA·dT, the values of twelve torsion angles must be ascertained (Figure 1.1); contrast this with a repeating polypeptide where only two conformation angles need ...
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Quantum-Mechanical Studies on the Conformation of Nucleic Acids and Their Constituents

1976
Publisher Summary This chapter discusses the results of the quantum-mechanical computations of the conformational properties of nucleic acids and their constituents, comparing the results obtained by different methods among themselves with the results of the empirical computations, and with the available experimental data as obtained by different ...
B, Pullman, A, Saran
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Influence of Lipid Membranes on the Conformational Transitions of Nucleic Acids

Journal of Biomolecular Structure and Dynamics, 1986
The conformational transitions of nucleic acids which were enclosed in reverse phase evaporation vesicles (REV) were studied by thermal denaturation with optical recording. Cloned fragments of double-stranded DNA containing 179 base pairs and 187 base pairs, respectively, and polyA.polyU were enclosed in REV with a yield up to every vesicle containing ...
B, Brosius, D, Riesner
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Conformational penalties: New insights into nucleic acid recognition

Current Opinion in Structural Biology
The energy cost accompanying changes in the structures of nucleic acids when they bind partner molecules is a significant but underappreciated thermodynamic contribution to binding affinity and specificity. This review highlights recent advances in measuring conformational penalties and determining their contribution to the recognition, folding, and ...
Ainan, Geng, Rohit, Roy, Hashim M, Al-Hashimi   +2 more
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Nucleic acid reactivity and conformation I. Deamination of cytosine by nitrous acid

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1972
Abstract The rate of deamination of cytosine to uracil by nitrous acid was measured under several sets of conditions for the following compounds: cytidine, cytidine 5′-phosphate, poly(cytidylic acid) (in both single-stranded and half-protonated double helix forms), and the poly(I) · poly(C) complex. The relative reactivity of nucleoside : nucleotide :
R, Shapiro, H, Yamaguchi
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