Results 241 to 250 of about 2,476,402 (307)

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

crRNA scaffold remodeling controls CRISPR-Cas12a activity for enhanced performance. [PDF]

Nucleic Acids Res
Wang Z, Wu Y, Wang Z, Zhang S, Liu H, Nie Y, Chen K, Huang Y, Zhou Y, Cao Y, Sun L, Hao R.   +11 more
europepmc   +1 more source

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

Membrane-Spanning Nanopores Formed from Nucleic Acids. [PDF]

Chem Rev
Li Y, Karrasch T, Keyser UF, Göpfrich K.   +3 more
europepmc   +1 more source

Sticker Valence Governs Chain Collapse and Liquid‐Liquid Phase Separation in Peptide‐Inspired Associative Polymers

Advanced Science, EarlyView.
Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Seung‐Hwan Oh, Jinhoon Lee, Seunghyun Lee, Raehyun Jung, Sangyeop Lee, Su‐Mi Hur, Dong Woog Lee, Soo‐Hyung Choi   +7 more
wiley   +1 more source

A universal and orthogonal safety valve for CRISPR/Cas12a without chemical modification or external stimulation. [PDF]

Nucleic Acids Res
Luo W, Wu Y, Ni D, Zhang L, Zhang Y, Han X, Zhang Y, Pu J, He Y, Yin N, Wang W, Huang R, Guo Y, Sun Y, Xie G.   +14 more
europepmc   +1 more source

Nucleotide sequence of a genomic fragment of the rat IGF-I gene spanning an alternate 5' non coding exon

, 1989
BUCCI, Cecilia, ROBERTS CT, FRUNZIO R, BRUNI CB, NUCLEIC ACID R.E.S., MALLUCCI P   +5 more
core  

Protein-directed nucleotide selection in the DRT3 defense system: mechanism, biological context, and constraints on programmability. [PDF]

Front Microbiol
Niazi SK.
europepmc   +1 more source

Polymer Concepts in Cellular Function

Advanced Science, EarlyView.
Miao Yu, Shikha Dhiman, Dorothee Dormann, Frauke Gräter, Katja Luck, Friederike Schmid, Andreas Walther, Edward A. Lemke   +7 more
wiley   +1 more source

Reshaping of the substrate-binding pocket to improve the catalytic activity of the non-specific endonuclease from <i>Pseudomonas fluorescens</i>. [PDF]

Front Bioeng Biotechnol
Zhang JY, Zhou LJ, Zhou Q, Si WJ, Wu Y, Zhang YW.   +5 more
europepmc   +1 more source