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Exploring the conformations of nucleic acids
Journal of Functional Programming, 1995Abstract This paper presents an application of functional programming in the field of molecular biology: exploring the conformations of nucleic acids. The Nucleic Acid three-dimensional structure determination problem (NA3D) and a constraint satisfaction algorithm are ...
Marcel Turcotte +2 more
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Conformations of double-helical nucleic acids
Nature, 1976A KNOWLEDGE of possible conformational states of double-helical nucleic acids is fundamental to an understanding of how they work1,2. Models for a series of conformations have been made on the basis of X-ray data3–5. Investigations of nucleic acids in solution point to the existence of a continuum of forms but do not make possible the quantitative ...
V E, Khutorsky, V I, Poltev
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Two contiguous conformations in a nucleic acid duplex
Nature, 1978DNA CONFORMATIONS and properties depend on DNA sequence and on environmental conditions1–3. It has been suggested that specific regulatory sites on DNA might have unique secondary conformations2. Conformational transitions, and the propagation of these transitions along a DNA helix, have been proposed as mechanistic steps in RNA transcription4 and DNA ...
E, Selsing +3 more
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Conformational Flexibility of Nucleic Acids
1983In consideration of the importance of conformational flexibility to the functioning of nucleic acids, NMR studies have been carried out to elucidate aspects of dynamics with molecular Mechanics calculations providing supplementary insight. Analysis of 31P and 13C NMR relaxation data in terms of plausible motions in a DNA helix indicate that winding and
Thomas L. James +7 more
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Forces involved in the Conformational Stability of Nucleic Acids
Nature, 1969ONE of the most important problems in research on nucleic acid is the understanding of the forces which maintain the helical structure. After the elucidation of the double helix by Watson and Crick1, the helical secondary structure of DNA was thought to derive its stability from hydrogen bonding between the base pair. The discovery that polynucleotides
J C, Maurizot, J, Brahms, F, Eckstein
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Conformation of Viral Nucleic Acids in Situ
1969Publisher Summary The problems that are discussed in this chapter are confined to viruses, and to be more exact, to the question of similarities and differences between the structure and properties of usual forms of nucleic acids in solution and that of nucleic acids inside viral particles.
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Conformational properties of nucleic acids in solution
International Journal of Quantum Chemistry, 2009Principles which govern the conformational properties of nucleic acid structures in aqueous solution are derived from extensive nuclear magnetic resonance studies of nucleic acid components. These principles are then utilized to project the solution conformation of tRNA.
Ramaswamy H. Sarma, Steven S. Danyluk
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Copper(II)-Nucleic acid interactions—A conformational study
Journal of Theoretical Biology, 1979Abstract The effect of copper complexation upon the conformational angles in mononucleotides and dinucleotides was studied using classical potential energy expressions. The geometrical parameters were taken from crystallographic reports on the base-metal complexes.
J, Bandekar, B K, Sathyanarayana
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Alternative conformations of a nucleic acid four-way junction
Journal of Molecular Biology, 2000A crystal structure of a 108 nucleotide RNA-DNA complex containing a four-way junction was solved at 3.1 A resolution. The structure of the junction differs substantially from the "stacked-X" conformation observed previously, due to a 135 degrees rotation of the branches.
J, Nowakowski +3 more
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Conformational principles of nucleic acids
1981From a conformational standpoint, nucleic acids are enormously complex. In order to rigorously describe, for example, the secondary structure of a repeating polynucleotide such as fibrous poly dA·dT, the values of twelve torsion angles must be ascertained (Figure 1.1); contrast this with a repeating polypeptide where only two conformation angles need ...
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