Results 251 to 260 of about 2,476,402 (307)

HMGB1 binds to and disrupts the hairpin structure of RNA15 and inhibits toll-like receptor activation. [PDF]

J Biol Chem
Lin C, Li P, Savitskaya AG, Lyukmanova E, Goncharuk SA, Mineev KS, Du X, Wang Y, Wang X.   +8 more
europepmc   +1 more source

Stability modification of therapeutic aptamers: from biostability bottlenecks to nuclease-resistant construct design. [PDF]

RSC Chem Biol
Pan Z, Pan Y, Zhang H, Chen Z, Zhang Y, Zhang B, Lu A, Zhang G, Yu S.   +8 more
europepmc   +1 more source

Mock Samples That Mimic Human Cervicovaginal Samples to Accelerate the Development and Evaluation of Assays for High-Risk HPV for Cervical Cancer Screening. [PDF]

J Med Virol
Novak EN, Ma A, Hansen CJ, Wazir Z, Bond M, Scheurer ME, Guo M, Salcedo MP, Schmeler KM, Richards-Kortum RR.   +9 more
europepmc   +1 more source

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Calculations of nucleic acid conformations

Current Opinion in Structural Biology, 1996
The present computational power and sophistication of theoretical approaches to nucleic acid structural investigation are sufficient for the realization of static and dynamic models that correlate accurately with current crystallographic, NMR and solution-probing structural data, and consequently are able to provide valuable insights and predictions ...
Auffinger, Pascal, Louise-May, Shirley, Westhof, Eric   +2 more
openaire   +4 more sources

Exploring the conformations of nucleic acids

Journal of Functional Programming, 1995
Abstract This paper presents an application of functional programming in the field of molecular biology: exploring the conformations of nucleic acids. The Nucleic Acid three-dimensional structure determination problem (NA3D) and a constraint satisfaction algorithm are ...
Marcel Turcotte, Guy Lapalme, François Major   +2 more
openaire   +2 more sources

The conformations of locked nucleic acids (LNA)

Journal of Molecular Recognition, 2000
We have used 2D NMR spectroscopy to study the sugar conformations of oligonucleotides containing a conformationally restricted nucleotide (LNA) with a 2'-O, 4'-C-methylene bridge. We have investigated a modified 9-mer single stranded oligonucleotide as well as three 9- and 10-mer modified oligonucleotides hybridized to unmodified DNA.
Petersen, Michael B., Nielsen, Christina B., Nielsen, Katrine E., Jensen, Gitte A., Bondensgaard, Kent, Singh, Sanjay Kumar, Rajwanshi, Vivek Kumar, Koshkin, Alexei, Dahl, Britta Mynster, Wengel, Jesper Thagaard, Jacobsen, Jens Peter   +10 more
openaire   +3 more sources

Conformations of double-helical nucleic acids

Nature, 1976
A KNOWLEDGE of possible conformational states of double-helical nucleic acids is fundamental to an understanding of how they work1,2. Models for a series of conformations have been made on the basis of X-ray data3–5. Investigations of nucleic acids in solution point to the existence of a continuum of forms but do not make possible the quantitative ...
V E, Khutorsky, V I, Poltev
openaire   +2 more sources

Hydroxystilbamidine. Nonintercalating drug as a probe of nucleic acid conformation

Biochemistry, 1973
M Daune
exaly   +3 more sources

Two contiguous conformations in a nucleic acid duplex

Nature, 1978
DNA CONFORMATIONS and properties depend on DNA sequence and on environmental conditions1–3. It has been suggested that specific regulatory sites on DNA might have unique secondary conformations2. Conformational transitions, and the propagation of these transitions along a DNA helix, have been proposed as mechanistic steps in RNA transcription4 and DNA ...
E, Selsing, R D, Wells, T A, Early, D R, Kearns   +3 more
openaire   +2 more sources