Results 271 to 280 of about 2,476,402 (307)

Single molecule approaches of nucleic acids conformational changes

Methods, 2019
Single molecule approaches of nucleic acids conformational changes One of the primordial questions today in biology is: how does DNA regulate its own metabolism? In other words, what are the mechanisms that enables specific genes to be transcribed while others are silenced?
Lavelle, Christophe, Tardin, Catherine
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Influence of Lipid Membranes on the Conformational Transitions of Nucleic Acids

Journal of Biomolecular Structure and Dynamics, 1986
The conformational transitions of nucleic acids which were enclosed in reverse phase evaporation vesicles (REV) were studied by thermal denaturation with optical recording. Cloned fragments of double-stranded DNA containing 179 base pairs and 187 base pairs, respectively, and polyA.polyU were enclosed in REV with a yield up to every vesicle containing ...
B, Brosius, D, Riesner
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Conformational penalties: New insights into nucleic acid recognition

Current Opinion in Structural Biology
The energy cost accompanying changes in the structures of nucleic acids when they bind partner molecules is a significant but underappreciated thermodynamic contribution to binding affinity and specificity. This review highlights recent advances in measuring conformational penalties and determining their contribution to the recognition, folding, and ...
Ainan, Geng, Rohit, Roy, Hashim M, Al-Hashimi   +2 more
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Theoretical Probes of Nucleic Acid Conformation

1983
The computations described briefly here illustrate the interrelationship between the local structure and macroscopic behavior of the DNA helix. Statistical mechanical studies help to identify the most likely morphological arrangements of the polynucleotide backbone and to understand the macroscopic flexibility of the DNA as a whole.
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Quantum-Mechanical Studies on the Conformation of Nucleic Acids and Their Constituents

1976
Publisher Summary This chapter discusses the results of the quantum-mechanical computations of the conformational properties of nucleic acids and their constituents, comparing the results obtained by different methods among themselves with the results of the empirical computations, and with the available experimental data as obtained by different ...
B, Pullman, A, Saran
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Optical activity and the conformation of polynucleotide models of nucleic acids

Journal of Molecular Biology, 1965
The interaction between polymers of adenylic and uridylic acids has been investigated using homopolyadenylate and homopolyuridylate, and copolymers containing various ratios of AMP and UMP randomly distributed. The measurements of circular dichroism in the region of 230 to 320 m μ indicate that the formation of the two-stranded poly (A + U)† helical ...
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On the conformation of native and denatured nucleic acids

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966
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Watersoluble synthetic nucleic acid analogs--polyethyleneimine derivatives containing nucleic acid bases--conformation and interactionwith nucleic acids.

Nucleic acids symposium series, 1991
Water soluble polyethyleneimine derivatives containing nucleic acid bases were found to interact with polynucleotides, DNA, RNA. The conformational change by formation of complex was observed by CD spectra and was discussed with the hypochromicity in UV spectra.
T, Wada, E, Mochizuki, Y, Inaki, K, Takemoto   +3 more
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Furanose ring conformation in nucleosides and nucleic acids

Journal of Molecular Biology, 1969
H R, Wilson, A, Rahman, P, Tollin
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A conformation-specific chemical modification of nucleic acids

Biochemical Pharmacology, 1988
P, Roques, M, Olomucki
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