Results 301 to 310 of about 205,585 (348)

Exploring the conformations of nucleic acids

Journal of Functional Programming, 1995
AbstractThis paper presents an application of functional programming in the field of molecular biology: exploring the conformations of nucleic acids. TheNucleic Acid three-dimensional structure determination problem(NA3D) and a constraint satisfaction algorithm are formally described.
Marcel Turcotte, Guy Lapalme, François Major   +2 more
openaire   +1 more source

Conformational Flexibility of Nucleic Acids

1983
In consideration of the importance of conformational flexibility to the functioning of nucleic acids, NMR studies have been carried out to elucidate aspects of dynamics with molecular Mechanics calculations providing supplementary insight. Analysis of 31P and 13C NMR relaxation data in terms of plausible motions in a DNA helix indicate that winding and
Thomas L. James, Peter Bendel, Jacqueline L. James, Joe W. Keepers, Peter A. Kollman, Aviva Lapidot, Joseph Murphy-Boesch, John E. Taylor   +7 more
openaire   +1 more source

Single molecule approaches of nucleic acids conformational changes

Methods, 2019
Single molecule approaches of nucleic acids conformational changes One of the primordial questions today in biology is: how does DNA regulate its own metabolism? In other words, what are the mechanisms that enables specific genes to be transcribed while others are silenced?
Lavelle, Christophe, Tardin, Catherine
openaire   +2 more sources

Two contiguous conformations in a nucleic acid duplex

Nature, 1978
DNA CONFORMATIONS and properties depend on DNA sequence and on environmental conditions1–3. It has been suggested that specific regulatory sites on DNA might have unique secondary conformations2. Conformational transitions, and the propagation of these transitions along a DNA helix, have been proposed as mechanistic steps in RNA transcription4 and DNA ...
E, Selsing, R D, Wells, T A, Early, D R, Kearns   +3 more
openaire   +2 more sources

Copper(II)-Nucleic acid interactions—A conformational study

Journal of Theoretical Biology, 1979
Abstract The effect of copper complexation upon the conformational angles in mononucleotides and dinucleotides was studied using classical potential energy expressions. The geometrical parameters were taken from crystallographic reports on the base-metal complexes.
J, Bandekar, B K, Sathyanarayana
openaire   +2 more sources

Forces involved in the Conformational Stability of Nucleic Acids

Nature, 1969
ONE of the most important problems in research on nucleic acid is the understanding of the forces which maintain the helical structure. After the elucidation of the double helix by Watson and Crick1, the helical secondary structure of DNA was thought to derive its stability from hydrogen bonding between the base pair. The discovery that polynucleotides
J C, Maurizot, J, Brahms, F, Eckstein
openaire   +2 more sources

Conformational penalties: New insights into nucleic acid recognition

Current Opinion in Structural Biology
The energy cost accompanying changes in the structures of nucleic acids when they bind partner molecules is a significant but underappreciated thermodynamic contribution to binding affinity and specificity. This review highlights recent advances in measuring conformational penalties and determining their contribution to the recognition, folding, and ...
Ainan, Geng, Rohit, Roy, Hashim M, Al-Hashimi   +2 more
openaire   +2 more sources

Conformational properties of nucleic acids in solution

International Journal of Quantum Chemistry, 2009
Principles which govern the conformational properties of nucleic acid structures in aqueous solution are derived from extensive nuclear magnetic resonance studies of nucleic acid components. These principles are then utilized to project the solution conformation of tRNA.
Ramaswamy H. Sarma, Steven S. Danyluk
openaire   +1 more source

Conformational principles of nucleic acids

1981
From a conformational standpoint, nucleic acids are enormously complex. In order to rigorously describe, for example, the secondary structure of a repeating polynucleotide such as fibrous poly dA·dT, the values of twelve torsion angles must be ascertained (Figure 1.1); contrast this with a repeating polypeptide where only two conformation angles need ...
openaire   +1 more source

Conformational Studies of Nucleic Acids: III. Empirical Multiple Correlation Functions for Nucleic Acid Torsion Angles

Journal of Biomolecular Structure and Dynamics, 1986
There are seven significantly variable torsion angles in each monomer unit of a polynucleotide. Because of this, it is computationally infeasible to consider the energetics of all conformations available to a nucleic acid without the use of simplifications.
D A, Pearlman, S H, Kim
openaire   +2 more sources