Results 311 to 320 of about 451,143 (385)

Hydroxystilbamidine. Nonintercalating drug as a probe of nucleic acid conformation

Biochemistry, 1973
B, Festy, M, Daune
openaire   +3 more sources

Conformations of double-helical nucleic acids

Nature, 1976
A KNOWLEDGE of possible conformational states of double-helical nucleic acids is fundamental to an understanding of how they work1,2. Models for a series of conformations have been made on the basis of X-ray data3–5. Investigations of nucleic acids in solution point to the existence of a continuum of forms but do not make possible the quantitative ...
V E, Khutorsky, V I, Poltev
openaire   +2 more sources

The conformations of locked nucleic acids (LNA)

Journal of Molecular Recognition, 2000
We have used 2D NMR spectroscopy to study the sugar conformations of oligonucleotides containing a conformationally restricted nucleotide (LNA) with a 2'-O, 4'-C-methylene bridge. We have investigated a modified 9-mer single stranded oligonucleotide as well as three 9- and 10-mer modified oligonucleotides hybridized to unmodified DNA.
Petersen, Michael B., Nielsen, Christina B., Nielsen, Katrine E., Jensen, Gitte A., Bondensgaard, Kent, Singh, Sanjay Kumar, Rajwanshi, Vivek Kumar, Koshkin, Alexei, Dahl, Britta Mynster, Wengel, Jesper Thagaard, Jacobsen, Jens Peter   +10 more
openaire   +3 more sources

Exploring the conformations of nucleic acids

Journal of Functional Programming, 1995
AbstractThis paper presents an application of functional programming in the field of molecular biology: exploring the conformations of nucleic acids. TheNucleic Acid three-dimensional structure determination problem(NA3D) and a constraint satisfaction algorithm are formally described.
Marcel Turcotte, Guy Lapalme, François Major   +2 more
openaire   +1 more source

A Framework Nucleic Acid Based Robotic Nanobee for Active Targeting Therapy

Advanced Functional Materials, 2020
DNA nanotechnology has provided new strategies and platforms for cargo delivery. However, DNA‐based nanostructures utilized for cargo delivery have mainly focused on static structures and passive targeting.
Taoran Tian, Dexuan Xiao, Tao Zhang, Yanjing Li, Sirong Shi, Wenyu Zhong, P. Gong, Zhangqian Liu, Qian Li, Yunfeng Lin   +9 more
semanticscholar   +1 more source

Selective Introduction of Nucleic Acids into Metal Organic Framework by Size, Conformation and Stability.

Journal of the American Chemical Society, 2020
We report the use metal organic frameworks for the selective inclusion of nucleic acids with different size, shape and capability of conformational transition.
Shuang Peng, Binglin Bie, Hongnan Jia, Heng Tang, Xiong Zhang, Yuqing Sun, Qi Wei, Fan Wu, Yushu Yuan, Hexiang Deng, Xiang Zhou   +10 more
semanticscholar   +1 more source

Two contiguous conformations in a nucleic acid duplex

Nature, 1978
DNA CONFORMATIONS and properties depend on DNA sequence and on environmental conditions1–3. It has been suggested that specific regulatory sites on DNA might have unique secondary conformations2. Conformational transitions, and the propagation of these transitions along a DNA helix, have been proposed as mechanistic steps in RNA transcription4 and DNA ...
E, Selsing, R D, Wells, T A, Early, D R, Kearns   +3 more
openaire   +2 more sources

Conformational Flexibility of Nucleic Acids

1983
In consideration of the importance of conformational flexibility to the functioning of nucleic acids, NMR studies have been carried out to elucidate aspects of dynamics with molecular Mechanics calculations providing supplementary insight. Analysis of 31P and 13C NMR relaxation data in terms of plausible motions in a DNA helix indicate that winding and
Thomas L. James, Peter Bendel, Jacqueline L. James, Joe W. Keepers, Peter A. Kollman, Aviva Lapidot, Joseph Murphy-Boesch, John E. Taylor   +7 more
openaire   +1 more source

Inhibiting Methicillin-Resistant Staphylococcus aureus by Tetrahedral DNA Nanostructure-Enabled Antisense Peptide Nucleic Acid Delivery.

Nano letters (Print), 2018
One of the biggest obstacles for the use of antisense oligonucleotides as antibacterial therapeutics is their limited uptake by bacterial cells without a suitable carrier, especially in multi-drug-resistant bacteria with a drug efflux mechanism. Existing
Yuxin Zhang, Wenjuan Ma, Ying Zhu, Sirong Shi, Qianshun Li, Chenchen Mao, Dan Zhao, Yuxi Zhan, Jiye Shi, Wei Li, Lihua Wang, C. Fan, Yunfeng Lin   +12 more
semanticscholar   +1 more source

Xeno Nucleic Acid Nanosensors for Enhanced Stability Against Ion-Induced Perturbations.

Journal of Physical Chemistry Letters, 2018
The omnipresence of salts in biofluids creates a pervasive challenge in designing sensors suitable for in vivo applications. Fluctuations in ion concentrations have been shown to affect the sensitivity and selectivity of optical sensors based on single ...
Alice J. Gillen, Justyna Kupis-Rozmysłowicz, C. Gigli, Nils Schuergers, A. Boghossian   +4 more
semanticscholar   +1 more source