Results 311 to 320 of about 438,619 (385)

PROTON MAGNETIC RESONANCE STUDIES OF NUCLEIC ACID CONFORMATION *

Annals of the New York Academy of Sciences, 1973
Paul S. Miller, Lou S. Kan, J. C. Barrett, Paul O. P. Ts'o   +3 more
openaire   +4 more sources

Hydroxystilbamidine. Nonintercalating drug as a probe of nucleic acid conformation

Biochemistry, 1973
Bernard Festy, Michel Daune
openaire   +4 more sources

Calculations of nucleic acid conformations

Current Opinion in Structural Biology, 1996
The present computational power and sophistication of theoretical approaches to nucleic acid structural investigation are sufficient for the realization of static and dynamic models that correlate accurately with current crystallographic, NMR and solution-probing structural data, and consequently are able to provide valuable insights and predictions ...
Auffinger, Pascal, Louise-May, Shirley, Westhof, Eric   +2 more
openaire   +4 more sources

The conformations of locked nucleic acids (LNA)

Journal of Molecular Recognition, 2000
We have used 2D NMR spectroscopy to study the sugar conformations of oligonucleotides containing a conformationally restricted nucleotide (LNA) with a 2'-O, 4'-C-methylene bridge. We have investigated a modified 9-mer single stranded oligonucleotide as well as three 9- and 10-mer modified oligonucleotides hybridized to unmodified DNA.
Petersen, Michael B., Nielsen, Christina B., Nielsen, Katrine E., Jensen, Gitte A., Bondensgaard, Kent, Singh, Sanjay Kumar, Rajwanshi, Vivek Kumar, Koshkin, Alexei, Dahl, Britta Mynster, Wengel, Jesper Thagaard, Jacobsen, Jens Peter   +10 more
openaire   +4 more sources

Exploring the conformations of nucleic acids

Journal of Functional Programming, 1995
AbstractThis paper presents an application of functional programming in the field of molecular biology: exploring the conformations of nucleic acids. TheNucleic Acid three-dimensional structure determination problem(NA3D) and a constraint satisfaction algorithm are formally described.
Marcel Turcotte, Guy Lapalme, François Major   +2 more
openaire   +1 more source

Two contiguous conformations in a nucleic acid duplex [PDF]

Nature, 1978
DNA CONFORMATIONS and properties depend on DNA sequence and on environmental conditions1–3. It has been suggested that specific regulatory sites on DNA might have unique secondary conformations2. Conformational transitions, and the propagation of these transitions along a DNA helix, have been proposed as mechanistic steps in RNA transcription4 and DNA ...
David R. Kearns, David R. Kearns, Thomas A. Early, Thomas A. Early, Erik Selsing, Erik Selsing, Robert D. Wells, Robert D. Wells   +7 more
openaire   +2 more sources

Conformations of double-helical nucleic acids

Nature, 1976
A KNOWLEDGE of possible conformational states of double-helical nucleic acids is fundamental to an understanding of how they work1,2. Models for a series of conformations have been made on the basis of X-ray data3–5. Investigations of nucleic acids in solution point to the existence of a continuum of forms but do not make possible the quantitative ...
V. E. Khutorsky, V. I. Poltev
openaire   +3 more sources

A Framework Nucleic Acid Based Robotic Nanobee for Active Targeting Therapy

Advanced Functional Materials, 2020
DNA nanotechnology has provided new strategies and platforms for cargo delivery. However, DNA‐based nanostructures utilized for cargo delivery have mainly focused on static structures and passive targeting.
Taoran Tian, Dexuan Xiao, Tao Zhang, Yanjing Li, Sirong Shi, Wenyu Zhong, P. Gong, Zhangqian Liu, Qian Li, Yunfeng Lin   +9 more
semanticscholar   +1 more source

Antimicrobials that affect the synthesis and conformation of nucleic acids [PDF]

Revue Scientifique et Technique de l'OIE, 2012
Several antimicrobials act by inhibiting the synthesis of nucleic acids (rifamycins, sulfamides, diaminopyridines), modifying their conformation (quinolones, coumarins) or causing irreversible lesions (nitroimidazoles, nitrofurans). The resistance mechanisms are: a reduction in intracytoplasmic accumulation, modification of the target or the production
T Guillard, E Cambau
openaire   +2 more sources

Selective Introduction of Nucleic Acids into Metal Organic Framework by Size, Conformation and Stability.

Journal of the American Chemical Society, 2020
We report the use metal organic frameworks for the selective inclusion of nucleic acids with different size, shape and capability of conformational transition.
Shuang Peng, Binglin Bie, Hongnan Jia, Heng Tang, Xiong Zhang, Yuqing Sun, Qi Wei, Fan Wu, Yushu Yuan, Hexiang Deng, Xiang Zhou   +10 more
semanticscholar   +1 more source