Results 321 to 330 of about 438,619 (385)
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Consequences of nucleic acid conformation on the binding of a trinuclear platinum drug.
Biochemistry, 1999BBR3464, a charged trinuclear platinum compound, is the first representative of a new class of anticancer drugs to enter phase I clinical trials. The structure of BBR3464 is characterized by two [trans-PtCl(NH(3))(2)] units linked by a tetraamine [trans ...
M. Kloster +3 more
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Nucleic acid conformation diversity: from structure to function and regulation
, 2001Nucleic acids are the structural supports of genetic material and therefore the key factors in many vital cellular processes. The double-stranded right-handed helix is a regular conformation adopted by both DNA and RNA in cells, but an increasing ...
P. Belmont, J. Constant, M. Demeunynck
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Conformational Flexibility of Nucleic Acids
1983In consideration of the importance of conformational flexibility to the functioning of nucleic acids, NMR studies have been carried out to elucidate aspects of dynamics with molecular Mechanics calculations providing supplementary insight. Analysis of 31P and 13C NMR relaxation data in terms of plausible motions in a DNA helix indicate that winding and
Peter Bendel +7 more
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, 1987
The ultraviolet resonance Raman (UVRR) bands of several guanine- and adenine-containing mononucleotides were measured, and were compared with the classical and UVRR spectra of 9-ethylguanine, which contains no furanose ring, in order to assess the effect
Y. Nishimura +4 more
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The ultraviolet resonance Raman (UVRR) bands of several guanine- and adenine-containing mononucleotides were measured, and were compared with the classical and UVRR spectra of 9-ethylguanine, which contains no furanose ring, in order to assess the effect
Y. Nishimura +4 more
semanticscholar +1 more source
Conformational properties of nucleic acids in solution
International Journal of Quantum Chemistry, 2009Principles which govern the conformational properties of nucleic acid structures in aqueous solution are derived from extensive nuclear magnetic resonance studies of nucleic acid components. These principles are then utilized to project the solution conformation of tRNA.
Ramaswamy H. Sarma, Steven S. Danyluk
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Nano letters (Print), 2018
One of the biggest obstacles for the use of antisense oligonucleotides as antibacterial therapeutics is their limited uptake by bacterial cells without a suitable carrier, especially in multi-drug-resistant bacteria with a drug efflux mechanism. Existing
Yuxin Zhang +12 more
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One of the biggest obstacles for the use of antisense oligonucleotides as antibacterial therapeutics is their limited uptake by bacterial cells without a suitable carrier, especially in multi-drug-resistant bacteria with a drug efflux mechanism. Existing
Yuxin Zhang +12 more
semanticscholar +1 more source
Forces involved in the Conformational Stability of Nucleic Acids
Nature, 1969ONE of the most important problems in research on nucleic acid is the understanding of the forces which maintain the helical structure. After the elucidation of the double helix by Watson and Crick1, the helical secondary structure of DNA was thought to derive its stability from hydrogen bonding between the base pair. The discovery that polynucleotides
J. Brahms +2 more
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Xeno Nucleic Acid Nanosensors for Enhanced Stability Against Ion-Induced Perturbations.
Journal of Physical Chemistry Letters, 2018The omnipresence of salts in biofluids creates a pervasive challenge in designing sensors suitable for in vivo applications. Fluctuations in ion concentrations have been shown to affect the sensitivity and selectivity of optical sensors based on single ...
Alice J. Gillen +4 more
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Evolution of conformational principles in nucleic acids
International Journal of Quantum Chemistry, 2009The analysis of conformations of nucleic acids and polynucleotides have been greatly simplified by the important observations that the nucleotide building blocks exhibit two classes of preferred conformations and that the flexibility in the polynucleotide chain resides mainly in the internucleotide PO linkages.
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Single molecule approaches of nucleic acids conformational changes
Methods, 2019Single molecule approaches of nucleic acids conformational changes One of the primordial questions today in biology is: how does DNA regulate its own metabolism? In other words, what are the mechanisms that enables specific genes to be transcribed while others are silenced?
Lavelle, Christophe, Tardin, Catherine
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