Results 51 to 60 of about 2,997,790 (301)
Molecules, 2021 Specific RNA sequences regulate functions essential to life. The Trans-Activation Response element (TAR) is an RNA stem–bulge–loop structure involved in several steps of HIV-1 replication.
Alice Sosic +5 more
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A typical example of protein-nucleic acid complex (PDB 1TRO).
, 2013 (A) Protein-nucleic acid binding structure with protein colored in blue and nucleic acid colored in red. (B) Plot of interfacial RMSD () as a function of the fraction of native contacts () for 1000 docking decoys of the typical complex.
Zhiqiang Yan (129434), Jin Wang (29560)
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Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
An Extended Dot-Bracket-Notation for Functional Nucleic Acids
, 2008 Functional nucleic acids are an attractive substrate for molecular computing. A nucleic acid molecule is a linear chain of covalently bound building blocks assembled in arbitrary order from a set of typically four nucleotides.
Zauner, Klaus-Peter, Ramlan, Effirul I.
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Original Synthesis of a Nucleolipid for Preparation of Vesicular Spherical Nucleic Acids
Nanomaterials, 2022 Spherical nucleic acids (SNAs)—nanostructures, consisting of a nanoparticle core densely functionalized with a shell of short oligonucleotide strands—are a rapidly emerging class of nanoparticle-based therapeutics with unique properties and specific ...
Erik Dimitrov +8 more
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Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Nanomaterials, 2019 Nucleic acid-based technologies are an emerging research focus area for pharmacological and biological studies because they are biocompatible and can be designed to produce a variety of scaffolds at the nanometer scale.
Ryan C. Oliver +4 more
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Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Biomolecules, 2023 The discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPRs (Acrs), has enabled the development of highly controllable and precise CRISPR-Cas tools.
Helen B. Belato, George P. Lisi
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Nucleic Acid (Patent US 2009/0019559 A1) [PDF]
, 2009 The invention relates to nucleic acid derived from Perkinsus marinus which encodes a 9-elongase, a Delta8-desaturase and a Delta5-desaturase enzyme.
Sayanova, O. V. +2 more
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