Results 31 to 40 of about 2,476,402 (307)

IFITs: Emerging Roles As Key Anti-Viral Proteins

open access: yesFrontiers in Immunology, 2014
Interferon-induced protein with tetratricopeptide repeats (IFITs) are a family of proteins which are strongly induced downstream of type I interferon (IFN) signaling.
Gregory I Vladimer   +2 more
doaj   +1 more source

Studies on the relation between heme and nucleic acid syntheses in erythroid cell. II. Nucleic acid synthesis in erythroblast of anemic rat treated with aminopterin and bromouracil [PDF]

open access: yes, 1968
With the bone marrow of anemic rats, which had received the repeated injections of phenylhydrazine once a day for three to four days, the effects of aminopterin and bromouracil on the nucleic acid metabolism of erythroblasts were observed in vivo ...
Shigehisa, Morio
core   +1 more source

Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions

open access: yesJournal of Nucleic Acids, 2011
Unnatural nucleosides have been explored to expand the properties and the applications of oligonucleotides. This paper briefly summarizes nucleic acid analogs in which the base is modified or replaced by an unnatural stacking group for the study of ...
Shu-ichi Nakano   +2 more
doaj   +1 more source

First High-Resolution Crystal Structures of DNA:2′-O-Methyl-RNA Heteroduplexes

open access: yesCrystals, 2022
Heteroduplexes composed of all-DNA and all-2′-OMe RNA strands do not occur in nature, but they have found application in the development of molecular beacons and could also be used as aptamers or elements of nucleic acid-based nanostructures that will ...
Rafał Dolot   +3 more
doaj   +1 more source

Lone Pair…π Contacts and Structure Signatures of r(UNCG) Tetraloops, Z-Turns, and Z-Steps: A WebFR3D Survey

open access: yesMolecules, 2022
Z-DNA and Z-RNA have long appeared as oddities to nucleic acid scientists. However, their Z-step constituents are recurrently observed in all types of nucleic acid systems including ribosomes.
Craig L. Zirbel, Pascal Auffinger
doaj   +1 more source

Conformation of nucleic acids and the analysis of the hypochromic effect [PDF]

open access: yesBiochemical Journal, 1970
The spectra of two double-helical RNA species isolated from virus-like particles found in the mycelium of Penicillium chrysogenum were measured at about 25 degrees C, and at 95 degrees C after denaturation to a single-stranded form, and compared with the spectrum of the equivalent mixture of nucleotides.
openaire   +2 more sources

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

open access: yes, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Christina Troiber   +3 more
core   +1 more source

A Chimeric DNA/RNA Antiparallel Quadruplex with Improved Stability

open access: yesChemistryOpen, 2022
Nucleic acid quadruplexes are proposed to play a role in the regulation of gene expression, are often present in aptamers selected for specific binding functions and have potential applications in medicine and biotechnology.
Elaina P. Boyle   +3 more
doaj   +1 more source

Conformational Dynamics of Biopolymers in the Course of Their Interaction: Multifaceted Approaches to the Analysis by the Stopped-Flow Technique with Fluorescence Detection

open access: yesPhotonics, 2023
This review deals with modern approaches to systematic research on molecular-kinetic mechanisms of damage recognition and removal by pro- and eukaryotic enzymes of DNA base excision repair.
Nikita A. Kuznetsov
doaj   +1 more source

The effect of neutral sugar distribution on the dilute solution conformation of sugar beet pectin [PDF]

open access: yes, 2012
A partially degraded sugar beet pectin (C) was found to be heterogeneous in composition with neutral sugar-rich fractions of both high and low hydrodynamic radii. A neutral sugar-poor fraction was found at intermediate hydrodynamic radii.
Morris, Gordon   +4 more
core   +1 more source

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