Biomedicines, 2020 Inflammatory bowel diseases (IBDs) are chronic conditions that can benefit from the combined treatment of adenosine receptor agonists and hyaluronic acid (HA), which, binding the CD44, has pro-survival effects.
Alessandra Bitto, Antonio Ieni
exaly +4 more sources
Molecules, 2021 A series of tripeptides TrpTrpPhe (1), TrpTrpTyr (2), and TrpTrpTyr[CH2N(CH3)2] (3) were synthesized, and their photophysical properties and non-covalent binding to polynucleotides were investigated.
Antonija Erben +4 more
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Polynucleotides Attenuate Atopic Dermatitis-like Inflammatory Signaling in Keratinocytes and Macrophages [PDF]
BiomedicinesBackground: Atopic dermatitis (AD) is a persistent and recurring skin disease characterized by epidermal barrier dysfunction, immune dysregulation, and elevated expression of proinflammatory mediators.
Ye Jin Ha +5 more
doaj +2 more sources
An Injectable Biopolymer Hydrogel Complex (PN/HA/B3) for Facial Skin Redensification and General Rejuvenation: Clinical Report on Device Safety and Efficacy [PDF]
Journal of Functional BiomaterialsThis study evaluated the safety and effectiveness of HYDRAGEL A2, an injectable medical device containing hyaluronic acid (HA), polynucleotides (PN), and niacinamide, for improving facial skin quality.
Alexandre Porcello +6 more
doaj +2 more sources
Tear Trough Rejuvenation With Injectable Biostimulatory Polynucleotides (VAMP) [PDF]
Plastic and Reconstructive Surgery, Global OpenSummary:. Tear trough rejuvenation presents a clinical challenge due to thin skin, superficial vasculature, and age-related volume loss. VAMP, manufactured by Prollenium, a polynucleotide-based biostimulatory injectable, is designed to support dermal ...
Noury Adel, MSc, DHM +5 more
doaj +2 more sources
Paeonia lactiflora Callus-Derived Polynucleotides Enhance Collagen Accumulation in Human Dermal Fibroblasts [PDF]
Journal of Functional BiomaterialsPlant-derived polynucleotides (PNs) have emerged as promising regenerative biomolecules; however, their mechanisms remain less defined than those of salmon-derived polydeoxyribonucleotides (S-PDRNs).
Soyoung Hwang +8 more
doaj +2 more sources
Granulomatous Reactions Following the Injection of Multiple Aesthetic Microimplants: A Complication Associated with Excessive Filler Exposure in a Predisposed Patient [PDF]
ReportsBackground and Clinical Significance: Granulomatous reactions are rare but clinically significant complications of aesthetic procedures involving dermal fillers, particularly in individuals with underlying immune dysregulation.
Marjorie Garcerant Tafur +1 more
doaj +2 more sources
A Real-World Study of Polynucleotides HPT for Treating Periorbital Hyperpigmentation [PDF]
Clinical, Cosmetic and Investigational DermatologyRaquel Amado,1 Yusra Al-Mukhtar,2 Eliana Lanza,3 Pierfrancesco Bove,4 Tristan Tan,5 Nurul Ain Abdullah,6 Gonca Gökdemir,7 Nazli Caf,8 Ayse Serap Karadag,9 Carolina Prussia,10 Maurizio Cavallini11 1Skin and Medical Cosmetics, West Malling, UK; 2Dr Yusra ...
Amado R +10 more
doaj +2 more sources
Plant-Derived Polynucleotides/Polydeoxyribonucleotides in Skin Biomaterials: Delivery Platforms and Bioactivity Attribution [PDF]
Journal of Functional BiomaterialsIn the fields of dermatology and skin biomaterials, polynucleotides (PN) and polydeoxyribonucleotides (PDRN) typically refer to deoxyribonucleic acid (DNA)-based polymers or heterogeneous DNA-fragment mixtures rather than ribonucleic acid (RNA ...
Hyun Joo Kim +3 more
doaj +2 more sources
Results of Shoulder Adhesive Capsulitis Treatment With the Use of Platelet Rich Plasma and Nucleotide Drugs: A Comparative Study [PDF]
Travmatologiâ i Ortopediâ Rossii, 2022 Background. Intra-articular injections of autologous platelet-rich plasma (PRP), which is a natural biological stimulant and affects various parts of the regenerative process, are often used in the treatment of adhesive capsulitis.
Alexey V. Lychagin +3 more
doaj +1 more source