Applied Sciences (Switzerland), 2021 Polynucleotides (PN) have long been known as an effective supportive therapy for wound healing. The present study investigated whether a hydrogel formulation containing PN and hyaluronic acid (PN + HA) could promote wound healing in an in vitro model of ...
Carlo Galli +2 more
exaly +3 more sources
Biomedicines, 2020 Inflammatory bowel diseases (IBDs) are chronic conditions that can benefit from the combined treatment of adenosine receptor agonists and hyaluronic acid (HA), which, binding the CD44, has pro-survival effects.
, Alessandra Bitto, Antonio Ieni
exaly +3 more sources
An Injectable Biopolymer Hydrogel Complex (PN/HA/B3) for Facial Skin Redensification and General Rejuvenation: Clinical Report on Device Safety and Efficacy [PDF]
Journal of Functional BiomaterialsThis study evaluated the safety and effectiveness of HYDRAGEL A2, an injectable medical device containing hyaluronic acid (HA), polynucleotides (PN), and niacinamide, for improving facial skin quality.
Alexandre Porcello +6 more
doaj +2 more sources
Granulomatous Reactions Following the Injection of Multiple Aesthetic Microimplants: A Complication Associated with Excessive Filler Exposure in a Predisposed Patient [PDF]
ReportsBackground and Clinical Significance: Granulomatous reactions are rare but clinically significant complications of aesthetic procedures involving dermal fillers, particularly in individuals with underlying immune dysregulation.
Marjorie Garcerant Tafur +1 more
doaj +2 more sources
Paeonia lactiflora Callus-Derived Polynucleotides Enhance Collagen Accumulation in Human Dermal Fibroblasts [PDF]
Journal of Functional BiomaterialsPlant-derived polynucleotides (PNs) have emerged as promising regenerative biomolecules; however, their mechanisms remain less defined than those of salmon-derived polydeoxyribonucleotides (S-PDRNs).
Soyoung Hwang +8 more
doaj +2 more sources
Tear Trough Rejuvenation With Injectable Biostimulatory Polynucleotides (VAMP) [PDF]
Plastic and Reconstructive Surgery, Global OpenSummary:. Tear trough rejuvenation presents a clinical challenge due to thin skin, superficial vasculature, and age-related volume loss. VAMP, manufactured by Prollenium, a polynucleotide-based biostimulatory injectable, is designed to support dermal ...
Noury Adel, MSc, DHM +5 more
doaj +2 more sources
Supersonic Cryogenic Jet Delivery of Polynucleotides Compared With Manual Intradermal Injection [PDF]
Plastic and Reconstructive Surgery, Global OpenBackground:. This study explores an alternative method of delivering polynucleotides (PNs) using a transdermal drug delivery device instead of traditional injection methods.
Michael Kim, MD +5 more
doaj +2 more sources
A Real-World Study of Polynucleotides HPT for Treating Periorbital Hyperpigmentation [PDF]
Clinical, Cosmetic and Investigational DermatologyRaquel Amado,1 Yusra Al-Mukhtar,2 Eliana Lanza,3 Pierfrancesco Bove,4 Tristan Tan,5 Nurul Ain Abdullah,6 Gonca Gökdemir,7 Nazli Caf,8 Ayse Serap Karadag,9 Carolina Prussia,10 Maurizio Cavallini11 1Skin and Medical Cosmetics, West Malling, UK; 2Dr Yusra ...
Amado R +10 more
doaj +2 more sources
The promising potential of polynucleotide injections for knee osteoarthritis: A systematic review of literature and meta‐analysis of randomized control trials [PDF]
Journal of Experimental OrthopaedicsPurpose The present study aims to synthesize and evaluate the evidence on the effectiveness of intra‐articular polynucleotides (PNs) for knee osteoarthritis (OA). Methods In March 2024, we searched MEDLINE, Emcare, Web of Science and Cochrane Library for
Joseph Elphingstone +4 more
doaj +2 more sources
Polynucleotide HPTTM-Based Hydrogels Exhibit Scavenging Activity Against Reactive Oxygen Species [PDF]
AntioxidantsThis study investigates the scavenger activity of Polynucleotide High Purification Technology (PN HPTTM), alone or in combination with hyaluronic acid (PN HPTTM + HA) against oxidative stress induced by hydrogen peroxide (H2O2). Since oxidative stress is
Maria Teresa Colangelo +3 more
doaj +2 more sources