Results 11 to 20 of about 11,904 (209)

Using long ssDNA polynucleotides to amplify STRs loci in degraded DNA samples. [PDF]

open access: yesPLoS ONE, 2017
Obtaining informative short tandem repeat (STR) profiles from degraded DNA samples is a challenging task usually undermined by locus or allele dropouts and peak-high imbalances observed in capillary electrophoresis (CE) electropherograms, especially for ...
Martín E Mautner   +5 more
doaj   +3 more sources

Study on Interaction of Cationic Porphyrazine with Synthetic Polynucleotides [PDF]

open access: yesAnalytical Cellular Pathology, 2013
Interactions of cationic tetrakis (N, N′, N″, N‴- tetramethyltetra-3, 4-pyridinoporphyrazinatozinc (II) (Zn (tmtppa)) with synthetic polynucleotides, poly (G-C) and poly (A-T), and calf thymus DNA have been characterized in 7.5 mM phosphate buffer of pH ...
Hamid Dezhampanah, Soghra Fyzolahjani
doaj   +2 more sources

Error Analysis of Chemically Synthesized Polynucleotides

open access: yesBioTechniques, 1998
Two single-stranded polynucleotide constructs, 123 and 126 nucleotides in length, were chemically synthesized using standard phosphoramidite chemistry.
Karl H. Hecker, Randolph L. Rill
doaj   +2 more sources

ANTISENSE POLYNUCLEOTIDES TO INDUCE EXON SKIPPING AND METHOD OF TREATING DYSTROPHIES [PDF]

open access: yes, 2023
Antisense polynucleotides and their use in pharmaceutical compositions to induce exon skipping in targeted exons of the gamma sarcoglycan gene are provided, along with methods of preventing or treating dystrophic diseases such as Limb-Girdle Muscular ...

core   +12 more sources

Bullous striae distensae in a young patient with cardiomyopathy

open access: yesDermatology Reports, 2023
Striae distensae (SD), also known as stretch marks, are observable linear scars that appear where dermal damage has occurred as a result of prolonged stretching of the skin. The actual pathophysiology of SD is still up for debate because its origins are
Yazeed Alowairdhi   +2 more
doaj   +1 more source

A Biomimetic Polynucleotides–Hyaluronic Acid Hydrogel Promotes the Growth of 3D Spheroid Cultures of Gingival Fibroblasts

open access: yesApplied Sciences, 2023
(1) Background: Three-dimensional cultures are useful tools to evaluate regenerative approaches in vitro, as they may mimic the spatial arrangement of cells more closely to natural tissues than routine 2D culture methods. (2) Methods: We investigated the
Maria Teresa Colangelo   +5 more
doaj   +1 more source

Topical natural-origin polynucleotides in radiation-induced skin and mucosal toxicity [PDF]

open access: yesFolia Medica, 2022
Seventy to 90 percent of patients who have received radiation treatment struggle with radiation skin and mucosal toxicity. The inflicted damage to progenitor cells and local microcirculation makes it more likely that wounds, infections, and fibrosis may ...
Stefania Giudici   +5 more
doaj   +3 more sources

Polydeoxyribonucleotides Pre-Clinical Findings in Bone Healing: A Scoping Review

open access: yesDentistry Journal, 2023
Aim: Polydeoxyribonucleotide (PDRN) is a chain-like polymer derived from DNA. Recent in vitro and animal studies have showcased the beneficial impacts of PDRN on the process of bone mending, whether used on its own or in conjunction with other substances
Mattia Manfredini   +5 more
doaj   +1 more source

L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells

open access: yesBiochemistry and Biophysics Reports, 2020
The inhibitory effect of D and L-polynucleotides of a given length (40-50n) on the catalytic activity of DNA polymerase β isolated from chromatin cells of acute myeloid leukemia HL-60 was evaluated. The synthesized L enantiomer was found to have a higher
S.V. Stovbun   +5 more
doaj   +1 more source

A Biomimetic Polynucleotides–Hyaluronic Acid Hydrogel Promotes Wound Healing in a Primary Gingival Fibroblast Model

open access: yesApplied Sciences, 2021
Polynucleotides (PN) have long been known as an effective supportive therapy for wound healing. The present study investigated whether a hydrogel formulation containing PN and hyaluronic acid (PN + HA) could promote wound healing in an in vitro model of ...
Maria Teresa Colangelo   +4 more
doaj   +1 more source

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