Results 41 to 50 of about 7,228 (175)

Error Analysis of Chemically Synthesized Polynucleotides

BioTechniques, 1998
Two single-stranded polynucleotide constructs, 123 and 126 nucleotides in length, were chemically synthesized using standard phosphoramidite chemistry.
Karl H. Hecker, Randolph L. Rill
doaj   +1 more source

On the Different Mode of Action of Au(I)/Ag(I)-NHC Bis-Anthracenyl Complexes Towards Selected Target Biomolecules

Molecules, 2020
Gold and silver N-heterocyclic carbenes (NHCs) are emerging for therapeutic applications. Multiple techniques are here used to unveil the mechanistic details of the binding to different biosubstrates of bis(1-(anthracen-9-ylmethyl)-3-ethylimidazol-2 ...
Francesca Binacchi, Federica Guarra, Damiano Cirri, Tiziano Marzo, Alessandro Pratesi, Luigi Messori, Chiara Gabbiani, Tarita Biver   +7 more
doaj   +1 more source

Single flap approach combined with periosteal pedicle flap as a regenerative procedure: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background Single flap approach (SFA) is a validated procedure for obtaining clinical attachment gain and pocket closure when applied to deep intraosseous defects. However, the presence of an interdental crater as well as the tooth location were associated with a lower rate of primary intention closure, possibly jeopardizing the outcome of the
Mattia Severi, Massimo Viola, Leonardo Trombelli   +2 more
wiley   +1 more source

Simplified SPAL technique to provide adequate peri‐implant phenotype: A pilot study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Correction of peri‐implant bone dehiscence (PIBD) and optimization of the peri‐implant soft‐tissue phenotype are critical for long‐term peri‐implant tissues stability. A simplified, one‐stage, transmucosal variant of the subperiosteal peri‐implant augmented layer (sSPAL) technique was appraised and evaluated.
Leonardo Trombelli, Chiara Franzini, Mattia Severi   +2 more
wiley   +1 more source

Raman Optical Activity as a Tool to Monitor Polynucleotide Conformation in Solutions

Chemistry – A European Journal, EarlyView.
Raman optical activity (ROA) studies of nucleic acids have been hindered by limited computational tools to link the spectra to the structure. The study shows that accurate density functional simulations are possible for model nucleotides, bringing more information about molecular geometry and dynamics in solutions.
Mohammed Siddhique Para Kkadan, Josef Kapitán, Jiří Kessler, Ondřej Zapletal, Valery Andrushchenko, Petr Bouř   +5 more
wiley   +1 more source

A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years

Pharmaceutics
In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These systems offer promising strategies for targeted and controlled drug delivery while
Magdalena Stevanović, Nenad Filipović
doaj   +1 more source

Origin of the Genetic Code Is Found at the Transition between a Thioester World of Peptides and the Phosphoester World of Polynucleotides

Life, 2019
The early metabolism arising in a Thioester world gave rise to amino acids and their simple peptides. The catalytic activity of these early simple peptides became instrumental in the transition from Thioester World to a Phosphate World.
Hyman Hartman, Temple F. Smith
doaj   +1 more source

Human APOBEC3G suppresses homologous recombination and LIG4‐independent end joining in DNA double‐strand break repair

The FEBS Journal, EarlyView.
Chromosomal DNA double‐strand breaks (DSBs) are repaired by homologous recombination and nonhomologous end joining (NHEJ). Recent work has additionally established theta‐mediated end‐joining (TMEJ) as a mechanism for DSB joining. Cells lacking NHEJ and TMEJ can repair DSBs in a homology‐dependent manner.
Shinta Saito, Miori Murayama, Usaki Arai, Sekifumi Akatsu, Ami Yamamoto, Misaki Kadoguchi, Noritaka Adachi   +6 more
wiley   +1 more source

Sequence specific binding of beta carboline alkaloid harmalol with deoxyribonucleotides: binding heterogeneity, conformational, thermodynamic and cytotoxic aspects. [PDF]

PLoS ONE, 2014
Base dependent binding of the cytotoxic alkaloid harmalol to four synthetic polynucleotides, poly(dA).poly(dT), poly(dA-dT).poly(dA-dT), poly(dG).poly(dC) and poly(dG-dC).poly(dG-dC) was examined by various photophysical and calorimetric studies, and ...
Sarita Sarkar, Prateek Pandya, Kakali Bhadra   +2 more
doaj   +1 more source

Hydrogels in Periodontal and Craniofacial Regeneration: Current Applications and Next‐Generation Biomaterials

Journal of Periodontal Research, EarlyView.
Hydrogel‐based therapies have proven to be valuable tools to address the unique regeneration challenges of complex multi‐domain periodontal and craniofacial tissues. This review highlights and classifies clinically approved and emerging hydrogel therapies indicated for the regeneration of periodontal and craniofacial tissues.
Z. Gouveia, M. Diba, B. T. Yilmaz, Jae‐Kook Cha, D. T. Wu, D. J. Mooney   +5 more
wiley   +1 more source