Results 51 to 60 of about 11,904 (209)

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

Spectroscopic study of polynucleotides in cationic w/o microemulsion.

, 1999
Water has an active and key role in determining the structure of DNA. Entrapment of DNA and of synthetic model polynucleotides in reverse micelles, where the water activity can easily be modulated, may be a useful way of assessing the influence of water ...
CEGLIE A., GIOMINI, Marcello, GIULIANI A. M., GIUSTINI, Mauro, BALESTRIERI E.   +4 more
core   +1 more source

Synthesis and Properties of Potentially Antiviral Polynucleotides. [PDF]

, 2018
Synthetic polynucleotides have been shown to exhibit antiviral properties in a variety of biological systems. This thesis describes the synthesis and properties of some novel and potentially active compounds.
Bell, L. D.
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An Enzymatic Platform for Late‐Stage (Radio)isotope Labelling of Oligonucleotides With Methyltransferases

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
State‐of‐the‐art synthesis of radiolabelled oligonucleotides involves multi‐step synthesis with high costs, extended timelines and significant radioactive waste generation. Herein, a dual‐methyltransferase platform enables late‐stage, site‐specific labelling, overcoming these limitations through reduced costs, faster turnaround and minimal radioactive ...
Christopher R. B. Swanson, Ulrich Kauhl, Martin R. Edelmann, Florian P. Seebeck   +3 more
wiley   +2 more sources

On the Different Mode of Action of Au(I)/Ag(I)-NHC Bis-Anthracenyl Complexes Towards Selected Target Biomolecules

Molecules, 2020
Gold and silver N-heterocyclic carbenes (NHCs) are emerging for therapeutic applications. Multiple techniques are here used to unveil the mechanistic details of the binding to different biosubstrates of bis(1-(anthracen-9-ylmethyl)-3-ethylimidazol-2 ...
Francesca Binacchi, Federica Guarra, Damiano Cirri, Tiziano Marzo, Alessandro Pratesi, Luigi Messori, Chiara Gabbiani, Tarita Biver   +7 more
doaj   +1 more source

A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years

Pharmaceutics
In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These systems offer promising strategies for targeted and controlled drug delivery while
Magdalena Stevanović, Nenad Filipović
doaj   +1 more source

Simplified SPAL technique to provide adequate peri‐implant phenotype: A pilot study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Correction of peri‐implant bone dehiscence (PIBD) and optimization of the peri‐implant soft‐tissue phenotype are critical for long‐term peri‐implant tissues stability. A simplified, one‐stage, transmucosal variant of the subperiosteal peri‐implant augmented layer (sSPAL) technique was appraised and evaluated.
Leonardo Trombelli, Chiara Franzini, Mattia Severi   +2 more
wiley   +1 more source

Raman Optical Activity as a Tool to Monitor Polynucleotide Conformation in Solutions

Chemistry – A European Journal, EarlyView.
Raman optical activity (ROA) studies of nucleic acids have been hindered by limited computational tools to link the spectra to the structure. The study shows that accurate density functional simulations are possible for model nucleotides, bringing more information about molecular geometry and dynamics in solutions.
Mohammed Siddhique Para Kkadan, Josef Kapitán, Jiří Kessler, Ondřej Zapletal, Valery Andrushchenko, Petr Bouř   +5 more
wiley   +1 more source

Polynucleotides derives du coronavirus et leur utilisation comme vaccins

, 2023
[EN] The present invention provides polynucleotides comprising: (a) a polynucleotide sequence of SEQ ID NO: 42 (SARSCoV-2A[3, E, 6 and 7] mutant) or SEQ ID NO: 43 (SARS-CoV-2A[3, E, 7 and 8] mutant); or (b) a variant of SEQ ID NO: 42 or a variant of SEQ
Solá Gurpegui, Isabel, Enjuanes Sánchez, Luis, Zúñiga Lucas, Sonia, Honrubia, José M., Muñoz-Santos, Diego, Loreto Belló-Pérez, Melissa   +5 more
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