Results 61 to 70 of about 17,878 (213)

pH-Sensitive Chitosan–Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells [PDF]

, 2019
Chitosan has been extensively studied as a genetic drug delivery platform. However, its efficiency is limited by the strength of DNA and RNA binding.
Korzhikov-Vlakh, Viktor, Pilipenko, Iuliia, Rühl, Eckart, Schäfer-Korting, Monika, Sharoyko, Vladimir, Tennikova, Tatiana, Zhang, Nan, Zoschke, Christian   +7 more
core   +1 more source

Single flap approach combined with periosteal pedicle flap as a regenerative procedure: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background Single flap approach (SFA) is a validated procedure for obtaining clinical attachment gain and pocket closure when applied to deep intraosseous defects. However, the presence of an interdental crater as well as the tooth location were associated with a lower rate of primary intention closure, possibly jeopardizing the outcome of the
Mattia Severi, Massimo Viola, Leonardo Trombelli   +2 more
wiley   +1 more source

Models of Low-Dimensional Vector-Fuzzy Representations of Genetic Sequences and Amino Acids

AppliedMath
Genetic sequences play a central role in biological and medical research, and mathematics provides powerful means for their representation and analysis.
Fotini Sereti, Dimitrios Georgiou, Theodoros Karakasidis   +2 more
doaj   +1 more source

Error Analysis of Chemically Synthesized Polynucleotides

BioTechniques, 1998
Two single-stranded polynucleotide constructs, 123 and 126 nucleotides in length, were chemically synthesized using standard phosphoramidite chemistry.
Karl H. Hecker, Randolph L. Rill
doaj   +1 more source

On the Different Mode of Action of Au(I)/Ag(I)-NHC Bis-Anthracenyl Complexes Towards Selected Target Biomolecules

Molecules, 2020
Gold and silver N-heterocyclic carbenes (NHCs) are emerging for therapeutic applications. Multiple techniques are here used to unveil the mechanistic details of the binding to different biosubstrates of bis(1-(anthracen-9-ylmethyl)-3-ethylimidazol-2 ...
Francesca Binacchi, Federica Guarra, Damiano Cirri, Tiziano Marzo, Alessandro Pratesi, Luigi Messori, Chiara Gabbiani, Tarita Biver   +7 more
doaj   +1 more source

Translocation of structured polynucleotides through nanopores

, 2004
We investigate theoretically the translocation of structured RNA/DNA molecules through narrow pores which allow single but not double strands to pass. The unzipping of basepaired regions within the molecules presents significant kinetic barriers for the ...
Akeson M, Bates M, Cate J H, Cech T R, Chuang J, Flomenbom O, Gerland U, Gerland U, Gutell R R, Hofacker I L, Karlin S, Koch S J, Lubensky D K, McCaskill J S, Meller A, Metzler R, Ralf Bundschuh, Terence Hwa, Ulrich Gerland, Walter A E, Zuker M   +20 more
core   +1 more source

Method of identifying inhibitors of glutathione S-transferase (GST) gene expression [PDF]

, 1999
Complementary DNA and genomic clones for three variants of GST-.pi. are disclosed. It is demonstrated that certain of these variants are overexpressed in gliomas, thereby indicating an involvement with that form of cancer.
Akande, Olanike, Ali-Osman, Francis, Antoun, Gamil, Buolamwini, John K., Keller, Charles W., Lo, Hui-Wen, Lopez-Berestein, Gabriel   +6 more
core   +1 more source

Highly Potent Fluorogenic Ligands for Triplex DNA: 5‐Substituted 2‐(Naphthalen‐2‐yl)‐4H‐Chromen‐4‐Ones

Chemistry – A European Journal, EarlyView.
5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran, Landy Gu, Krege M. Christison, Kalee Thao, Liang Xue   +4 more
wiley   +1 more source

Effect of polydeoxyribonucleotide therapy on the regeneration of long-term non-healing postoperative skin defects

RUDN Journal of Medicine
Relevance. Chronic wound healing currently remains a serious problem due to its frequency and associated complications. Polydeoxyribonucleotide therapy, which promotes angiogenesis and tissue regeneration, offers a promising treatment.
Alexey G. Baranovskiy, Yelena Yu. Shapovalova, Yuri G. Baranovskiy, Boris I. Kuzminov, Svetlana V. Harchenko, Igor A. Lugin, Lilian A. Kutuzova, Tatiana P. Sataieva, Sergey V. Popov, Kamil R. Bakhtiyarov, Daniil Yu. Yuferov, Grigory A. Demyashkin   +11 more
doaj   +1 more source

U.S. Patent Literature Survey of Agrobacterium-Mediated Transformation of Sweet Potato (Ipomoea Batatas) [PDF]

, 2007
A team of researchers and patent information scientists at Franklin Pierce Law Center were asked to evaluate the patent and literature landscape related to the Agrobacterium-mediated transformation in sweet potato with respect to the U.S.
Cavicchi, Jon R., Kowalski, Stanley P., Murthy, J. Jaya, Vartak, Rahul R.   +3 more
core   +1 more source