Results 61 to 70 of about 9,001 (206)

Chemical Syntheses of 3′ and 5′ Phosphorylated Oligonucleotides: An Overview

European Journal of Organic Chemistry, Volume 29, Issue 21, 4 June 2026.
This review provides an overview of the various chemical methods employed in the synthesis of oligonucleotides bearing a phosphate group at their 3′ or 5′ end. Notably, it presents modified phosphoramidites and supports developed for this purpose. Oligonucleotides (ON) with a phosphate monoester group at their 3′ or 5′ end have applications in many ...
Rémy Lartia
wiley   +1 more source

Polynucleotides derives du coronavirus et leur utilisation comme vaccins

, 2023
[EN] The present invention provides polynucleotides comprising: (a) a polynucleotide sequence of SEQ ID NO: 42 (SARSCoV-2A[3, E, 6 and 7] mutant) or SEQ ID NO: 43 (SARS-CoV-2A[3, E, 7 and 8] mutant); or (b) a variant of SEQ ID NO: 42 or a variant of SEQ
Solá Gurpegui, Isabel, Enjuanes Sánchez, Luis, Zúñiga Lucas, Sonia, Honrubia, José M., Muñoz-Santos, Diego, Loreto Belló-Pérez, Melissa   +5 more
core  

Sequence specific binding of beta carboline alkaloid harmalol with deoxyribonucleotides: binding heterogeneity, conformational, thermodynamic and cytotoxic aspects. [PDF]

PLoS ONE, 2014
Base dependent binding of the cytotoxic alkaloid harmalol to four synthetic polynucleotides, poly(dA).poly(dT), poly(dA-dT).poly(dA-dT), poly(dG).poly(dC) and poly(dG-dC).poly(dG-dC) was examined by various photophysical and calorimetric studies, and ...
Sarita Sarkar, Prateek Pandya, Kakali Bhadra   +2 more
doaj   +1 more source

The Polymers of Life: Exploring Cellular Function Through Polymer Concepts

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, Volume 65, Issue 23, 1 June 2026.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Nucleic Acid-Based Therapeutics for Periodontal Tissue Regeneration: A Comprehensive Review

Applied Sciences
Polydeoxyribonucleotides (PDRNs) and polynucleotides (PNs) are biologically active DNA-derived polymers with emerging applications in regenerative dentistry. Acting through adenosine A2A receptor activation and modulation of inflammatory responses, these
Jwa-Young Kim, Min-Ho Hong, Seong-Gon Kim, Umberto Garagiola   +3 more
doaj   +1 more source

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, Volume 73, Issue 3, Page 1137-1150, June 2026.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

Polynucleotides [PDF]

Nature, 1972
Morio Ikehara, Masao Hattori
  +4 more sources

Prospective Multicentre Real-World Study of a Bioregenerative Combination Therapy with Polynucleotide High-Purification Technology (PN HPT™) and Hyaluronic Acid for Moderate-to-Severe Atrophic Facial Acne Scars

Cosmetics
Background: Facial atrophic acne scars have a significant impact on patients’ psychosocial well-being and remain a therapeutic challenge. Existing treatments options are frequently limited by modest efficacy and adverse effects.
Ting Song Lim, Chong Ian, Nurul Ain Abdullah, Tristan Tan, Kuok Tjun Ong, Leda Moro, Maria Tomat, Carmen De Luca, Simona Piscopo, Carolina Prussia, Carlotta Bortoletti   +10 more
doaj   +1 more source

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling

Glia, Volume 74, Issue 6, June 2026.
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro, Quentin Brassart, Valérie Fraulob, Laura Calzà, Wojciech Krezel   +4 more
wiley   +1 more source