Results 31 to 40 of about 7,228 (175)

Complexation of Oligo- and Polynucleotides with Methoxyphenyl-Functionalized Imidazolium Surfactants

Pharmaceutics, 2022
Interaction between cationic surfactants and nucleic acids attracts much attention due to the possibility of using such systems for gene delivery. Herein, the lipoplexes based on cationic surfactants with imidazolium head group bearing methoxyphenyl ...
Darya A. Kuznetsova, Denis M. Kuznetsov, Leysan A. Vasileva, Syumbelya K. Amerhanova, Dilyara N. Valeeva, Diana V. Salakhieva, Viktoriia A. Nikolaeva, Irek R. Nizameev, Daut R. Islamov, Konstantin S. Usachev, Alexandra D. Voloshina, Lucia Ya. Zakharova   +11 more
doaj   +1 more source

Prebiotic selection for motifs in a model of template-free elongation of polymers within compartments. [PDF]

PLoS ONE, 2017
The transition from prelife where self-replication does not occur, to life which exhibits self-replication and evolution, has been a subject of interest for many decades. Membranes, forming compartments, seem to be a critical component of this transition
Grant Kinsler, Sam Sinai, Nicholas Keone Lee, Martin A Nowak   +3 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Real-World Evaluation of an Injectable Treatment Containing Polynucleotides Purified with High Purification Technology (PN HPT) and Hyaluronic Acid for Skin Quality Improvement in Facial and Body Areas

Cosmetics
Polynucleotides purified through High Purification Technology (PN HPT), combined with hyaluronic acid (HA), represent a novel injectable strategy to improve skin quality in aesthetic medicine.
Antonella Savoia, Simona Piscopo, Mario Rasulo, Umberto De Rosa, Annamaria D’Ardis, Luisa Cerutti, Stefania Bizzarri, Nicolle Tascon, Annalisa Forni, Roberta Perna, Ilaria Proietti, Carolina Prussia   +11 more
doaj   +1 more source

Kinetic studies on the phosphorolysis of polynucleotides by polynucleotide phosphorylase

Journal of Biological Chemistry, 1975
The kinetics of the phosphorolysis of polynucleotide (as differentiated from oligonucleotide) by polynucleotide phosphorylase of Micrococcus luteus has been investigated. Double reciprocal plots of initial velocity against either inorganic phosphate or polynucleotide concentration are linear, and furthermore, the affinity of the enzyme for either ...
J Y, Chou, M F, Singer, P, McPhie
openaire   +2 more sources

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Models of Low-Dimensional Vector-Fuzzy Representations of Genetic Sequences and Amino Acids

AppliedMath
Genetic sequences play a central role in biological and medical research, and mathematics provides powerful means for their representation and analysis.
Fotini Sereti, Dimitrios Georgiou, Theodoros Karakasidis   +2 more
doaj   +1 more source

Effect of polydeoxyribonucleotide therapy on the regeneration of long-term non-healing postoperative skin defects

RUDN Journal of Medicine
Relevance. Chronic wound healing currently remains a serious problem due to its frequency and associated complications. Polydeoxyribonucleotide therapy, which promotes angiogenesis and tissue regeneration, offers a promising treatment.
Alexey G. Baranovskiy, Yelena Yu. Shapovalova, Yuri G. Baranovskiy, Boris I. Kuzminov, Svetlana V. Harchenko, Igor A. Lugin, Lilian A. Kutuzova, Tatiana P. Sataieva, Sergey V. Popov, Kamil R. Bakhtiyarov, Daniil Yu. Yuferov, Grigory A. Demyashkin   +11 more
doaj   +1 more source