Results 11 to 20 of about 2,997,790 (301)

Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions [PDF]

open access: yesJournal of Nucleic Acids, 2011
Unnatural nucleosides have been explored to expand the properties and the applications of oligonucleotides. This paper briefly summarizes nucleic acid analogs in which the base is modified or replaced by an unnatural stacking group for the study of ...
Shu-ichi Nakano   +2 more
doaj   +2 more sources

Conformational analysis of nucleic acids revisited: Curves+ [PDF]

open access: yesNucleic Acids Research, 2009
We describe Curves+, a new nucleic acid conformational analysis program which is applicable to a wide range of nucleic acid structures, including those with up to four strands and with either canonical or modified bases and backbones. The program is algorithmically simpler and computationally much faster than the earlier Curves approach, although it ...
Lavery, R.   +4 more
openaire   +4 more sources

Conformational analysis of Infectious bursal disease virus (IBDV) derived cell penetrating peptide (CPP) analogs

open access: yesVeterinary World, 2013
Aim: This study was designed to develop peptide analogs of Infectious Bursal Disease (IBD) virus VP5 protein segment having cell penetrating ability to improve their interaction with cargo molecule (Nucleic acid) without affecting the backbone ...
Vinay G. Joshi   +5 more
doaj   +1 more source

Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM) [PDF]

open access: yes, 2003
Pyrrolidine-amide oligonucleotide mimics (POM) 1 were designed to be stereochemically and conformationally similar to natural nucleic acids, but with an oppositely charged, cationic backbone.
Tan, T. H. Samuel   +14 more
core   +1 more source

Nucleic Acid-tagged Peptides: Encoding Libraries and Controlling Dimerization and Conformation

open access: yesCHIMIA, 2013
Recent progress in the synthesis, screening, and self-assembly of nucleic acid–tagged peptidic libraries is reviewed.
Kalyan K. Sadhu, Nicolas Winssinger
doaj   +1 more source

Nucleic acid-based biosensors: analytical devices for prevention, diagnosis and treatment of diseases

open access: yesVitae, 2021
BACKGROUND : Biosensing techniques have been the subject of exponentially increasing interest due to their performance advantages such as high selectivity and sensitivity, easy operation, low cost, short analysis time, simple sample preparation, and real-
Laura Carvajal Barbosa   +5 more
doaj   +1 more source

Algorithms for Nucleic Acid Sequence Design [PDF]

open access: yes, 2010
Motivated by a growing field of research focused on programming function into biomolecules, we seek to decrease the cost of high-quality rational nucleic acid sequence design while increasing its versatility and availability.
Zadeh, Joseph N.
core   +1 more source

Editorial: Nucleic Acid-Associated Inflammation. [PDF]

open access: yes, 2021
Editorial on the Research Topic Nucleic Acid-Associated ...
Verrier, Eloi   +24 more
core   +1 more source

Spectrophotometric and nucleic acid-binding properties of halloysite clay nanotubes and kaolinite

open access: yesHeliyon, 2023
Halloysite particles (HNTs) are naturally occurring aluminosilicate nanotubes of low toxicity that have shown great promise for drug and biomolecule delivery into human and animal cells.
Shubha R.L. Malla   +4 more
doaj   +1 more source

Advances in the Determination of Nucleic Acid Conformational Ensembles [PDF]

open access: yesAnnual Review of Physical Chemistry, 2014
Conformational changes in nucleic acids play a key role in the way genetic information is stored, transferred, and processed in living cells. Here, we describe new approaches that employ a broad range of experimental data, including NMR-derived chemical shifts and residual dipolar couplings, small-angle X-ray scattering, and computational approaches ...
Loïc, Salmon   +2 more
openaire   +2 more sources

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