Results 91 to 100 of about 225,030 (341)

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

New Uses for the Personal Glucose Meter: Detection of Nucleic Acid Biomarkers for Prostate Cancer Screening

Sensors, 2020
A personal glucose meter (PGM)-based method for quantitative detection of a urinary nucleic acid biomarker in prostate cancer screening, the so-called PCA3, is reported herein.
Clara Abardía-Serrano, Rebeca Miranda-Castro, Noemí de-los-Santos-Álvarez, María Jesús Lobo-Castañón   +3 more
doaj   +1 more source

DNA as a universal substrate for chemical kinetics [PDF]

, 2009
Molecular programming aims to systematically engineer molecular and chemical systems of autonomous function and ever-increasing complexity. A key goal is to develop embedded control circuitry within a chemical system to direct molecular events.
Andrianantoandro, Arkin, Ashkenasy, Bath, Benner, D. Soloveichik, E. Winfree, G. Seelig, Green, Hjelmfelt, Hjelmfelt, Keasling, Klonowski, Levskaya, Okamoto, Panyutin, Panyutin, Ran, Reynaldo, Rothemund, Seelig, Tyson, Weinstock, Win, Wolf, Yin, Yurke, Zhang, Zhang   +28 more
core   +2 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Detection of Circovirus in Foxes with Meningoencephalitis, United Kingdom, 2009–2013

Emerging Infectious Diseases, 2015
A fox circovirus was identified in serum samples from foxes with unexplained neurologic signs by using viral metagenomics. Fox circovirus nucleic acid was localized in histological lesions of the cerebrum by in situ hybridization. Viruses from the family
Steve Bexton, Lidewij C. Wiersma, Sarah Getu, Peter R. van Run, Georges M.G.M. Verjans, Debby Schipper, Claudia M.E. Schapendonk, Rogier Bodewes, Lucy Oldroyd, Bart L. Haagmans, Marion M.P. Koopmans, Saskia L. Smits   +11 more
doaj   +1 more source

From aptamer-based biomarker discovery to diagnostic and clinical applications: an aptamer-based, streamlined multiplex proteomic assay [PDF]

, 2010
Recently, we reported an aptamer-based, highly multiplexed assay for the purpose of biomarker identification. To enable seamless transition from highly multiplexed biomarker discovery assays to a format suitable and convenient for diagnostic and life ...
Christopher Bock, Dom Zichi, Evaldas Katilius, Glenn M. Sanders, Jonathon D. Vaught, Larry Gold, Nancy Kim, Nicholas A. Saccomano, Sheri K. Wilcox, Stephan Kraemer, Tracy R. Keeney   +10 more
core   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Detection of Common Bacterial Causes of STIs among STD Clinic Attendees by Gram Stain and Culture versus the Microarray Nucleic Acid Hybridization Method

Central Asian Journal of Medical Sciences, 2017
Objectives: The purpose of the study was to determine the prevalence and etiology of predominant sexually transmitted infections (STIs) occurring among the STD and Gynecology Clinic attendees and to compare sensitivity and specificity of conventional ...
Jugderjav Badrakh, Bulbul Aumakhan, Baatarkhuu Oidov, Unursaikhan Ganbat, Erdenechimeg Choijiljav, Naranbat Nymadawa, Nymadawa Pagvajav   +6 more
doaj   +1 more source

Impedimetric Sensing of Factor V Leiden Mutation by Zip Nucleic Acid Probe and Electrochemical Array

Biosensors, 2020
A carbon nanofiber enriched 8-channel screen-printed electrochemical array was used for the impedimetric detection of SNP related to Factor V Leiden (FV Leiden) mutation, which is the most common inherited form of thrombophilia.
Arzum Erdem, Ece Eksin
doaj   +1 more source

Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450 [PDF]

, 2006
Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection.
Arnold, Frances H., Bloom, Jesse D., Endelman, Jeffrey B., Hiraga, Kaori, Landwehr, Marco, Otey, Christopher R.   +5 more
core   +1 more source