Results 91 to 100 of about 316,767 (328)

ClampFISH detects individual nucleic-acid molecules using click chemistry based amplification

Nature Biotechnology, 2018
Methods for detecting single nucleic acids in cell and tissues, such as fluorescence in situ hybridization (FISH), are limited by relatively low signal intensity and nonspecific probe binding.
Sara H. Rouhanifard, Ian A. Mellis, Margaret C. Dunagin, Sareh Bayatpour, Connie L. Jiang, Ian P. Dardani, Orsolya Symmons, Benjamin L. Emert, E. Torre, Allison Coté, Alessandra M. Sullivan, J. Stamatoyannopoulos, A. Raj   +12 more
semanticscholar   +1 more source

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

New Tools for Oligonucleotide Fingerprinting

BioTechniques, 2001
Oligonucleotide fingerprinting is an attractive, high-throughput complement to tag sequencing methods to determine the spectrum and abundance of genes in cDNA libraries.
A. Guerasimova, L. Nyarsik, I. Girnus, M. Steinfath, W. Wruck, H. Griffiths, R. Herwig, C. Wierling, J. O’Brien, H. Eickhoff, H. Lehrach, U. Radelof   +11 more
doaj   +1 more source

Scanning single-molecule counting system for Eprobe with highly simple and effective approach.

PLoS ONE, 2020
Here, we report a rapid and ultra-sensitive detection technique for fluorescent molecules called scanning single molecular counting (SSMC). The method uses a fluorescence-based digital measurement system to count single molecules in a solution.
Takeshi Hanami, Tetsuya Tanabe, Takuya Hanashi, Mitsushiro Yamaguchi, Hidetaka Nakata, Yasumasa Mitani, Yasumasa Kimura, Takahiro Soma, Kengo Usui, Michiko Isobe, Takashi Ogawa, Masayoshi Itoh, Yoshihide Hayashizaki, Seiji Kondo   +13 more
doaj   +1 more source

Using Peptide Nucleic Acid Hybridization Probes for Qualitative and Quantitative Analysis of Nucleic Acid Therapeutics by Capillary Electrophoresis. [PDF]

Anal Chem, 2023
Hutanu A, Signori C, Moritz B, Gregoritza M, Rohde A, Schwarz MA.   +5 more
europepmc   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Recent developments in the characterization of nucleic acid hybridization kinetics. [PDF]

Curr Opin Biomed Eng, 2021
Chen YI, Sripati MP, Nguyen TD, Chang YJ, Kuo YA, Hong S, Yeh HC.   +6 more
europepmc   +1 more source

Unraveling the Complexity of the Dzyaloshinskii–Moriya Interaction in Layered Magnets: The Full Magnitude and Chirality Control

Advanced Materials, EarlyView.
In layered magnets, the atomistic Dzyaloshinskii–Moriya interaction (DMI) depends critically not only on the orbital occupancy of the interface layer but also on the sequence of the atomic layers. The effect can be understood by analyzing the contributions of different orbitals to DMI.
Khalil Zakeri, Albrecht von Faber, Sergiy Mankovsky, Hubert Ebert   +3 more
wiley   +1 more source

Nucleic acid hybridization studies on Microbacterium, Curtobacterium, Agromyces and related taxa.

Journal of General Microbiology, 1982
Thirty strains of Agromyces, Arthrobacter, Curtobacterium, Brevibacterium, Corynebacterium and Microbacterium, exhibiting the rare peptidoglycan of group B, were subjected to extensive nucleic acid hybridization studies.
H. Döpfer, E. Stackebrandt, F. Fiedler
semanticscholar   +1 more source

Mussel‐Inspired Molecular Strategies for Fabricating Functional Materials With Underwater Adhesion and Self‐Healing Properties

Advanced Materials, EarlyView.
This review systematically examines the nanomechanical mechanisms of mussel‐inspired molecular interactions, primarily investigated by direct force measurement techniques such as surface forces apparatus and atomic force microscopy. The macroscopic adhesive and self‐healing performances of mussel‐inspired functional materials, including coacervates ...
Pan Huang, Hongjian Zhang, Hongbo Zeng
wiley   +1 more source