Results 141 to 150 of about 225,030 (341)
Advanced Science, EarlyView.We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun +5 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai +6 more
wiley +1 more source
Advanced Science, EarlyView.A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin +6 more
wiley +1 more source
Synergistic Mn‐MOF Activation of Pistol Ribozymes for Cancer Immunotherapy
Advanced Science, EarlyView.A Mn2+‐based metal–organic framework delivers a catalytic Pistol ribozyme for targeted PD‐L1 mRNA cleavage in tumor cells, with the released Mn2+ not only inducing immune activation in immune cells but also increasing the Pistol ribozyme catalytic activity.
Ming Zhao +10 more
wiley +1 more source
Small StructuresPeptide‐based hydrogels provide biocompatible, stimuli‐responsive platforms, while peptide‐DNA hybrids extend programmability through hybridization‐driven crosslinking. However, nucleobase incorporation can influence peptide self‐assembly pathways.
Huiling Lei +9 more
doaj +1 more source
Label-Free Detection of Zeptomol miRNA via Peptide Nucleic Acid Hybridization Using Novel Cyclic Voltammetry Method. [PDF]
Sensors (Basel), 2020 Takase S, Miyagawa K, Ikeda H.
europepmc +1 more source
Advanced Science, EarlyView.We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li +10 more
wiley +1 more source
Photoelectrochemical Detection of Dengue-Related Oligonucleotide Sequence Using Anthocyanin as an Intercalating Agent and Electrochromic Material [PDF]
, 2010 World Health Organization (WHO) presupposes a confirmation of dengue virus infection diagnosis with two criteria, i.e. clinical and laboratory criteria.
Ibrahim, A. S. (Anwar) +2 more
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