Results 111 to 120 of about 437,756 (347)

Thermodynamic Assessment of Prebiotic Molecule Formation Pathways on Comets

Universe
Comets are chemically rich and thermally extreme, spanning surface temperatures from ~50 K in the Oort Cloud to >1000 K for sungrazing bodies. These conditions may support key steps of prebiotic chemistry, including the synthesis of nucleic acid ...
Luca Tonietti
doaj   +1 more source

Role of HIV RNA structure in recombination and speciation: romping in purine A, keeps HTLV away

, 2013
Extreme enrichment of the human immunodeficiency virus (HIV-1) RNA genome for the purine A parallels the mild purine-loading of the RNAs of most organisms.
Forsdyke, Donald R.
core   +1 more source

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology
Pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasms (IPMNs) are pancreatic ductal adenocarcinoma (PDAC) precursor lesions.
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
doaj   +1 more source

High‐Concentration Antibody Formulation via Solvent‐Based Dehydration

Advanced Materials, EarlyView.
Amorphous solid antibodies are encapsulated into hydrogel microparticles through a solvent‐based dehydration process. The solvent extracts water from antibody solution droplets, causing the antibody to concentrate, and precipitation of the antibody into amorphous solid is induced.
Talia Zheng, Lucas Attia, Janet Teng, Patrick S. Doyle   +3 more
wiley   +1 more source

Fluorescent nanoparticles for sensing

, 2020
Nanoparticle-based fluorescent sensors have emerged as a competitive alternative to small molecule sensors, due to their excellent fluorescence-based sensing capabilities.
Acosta, Alarcón-Angeles, Albertazzi, Aldewachi, Ali, Ali, Alivisatos, Amelia, Amin, Arai, Arcudi, Bae, Bagwe, Behnke, Berti, Bhattacharyya, Biteen, Bruchez, Byrappa, Cai, Cao, Carregal-Romero, Chai, Chandra, Chen, Chen, Chen, Chen, Chen, Chen, Choi, Chu, Colom, De Luca, del Mercato, del Mercato, Derr, Dhenadhayalan, Diaz-Diestra, Ding, Dmitriev, Dong, Duong, Duong, Enkin, Fehérvári, Fernández-Argüelles, Fong, Fu, Furukawa, Gao, Govindaraju, Guo, Ha, Halter, Herschel, Hines, Hornig, Hou, Hu, Huang, Huang, Huang, Iyer, Jelinek, Jeong, Jiang, Jimenez de Aberasturi, Jin, Kim, Kircher, Kong, Lakowicz, Lan, Lee, Lemon, Leobandung, Leonhardt, Lepore, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Lim, Lin, Lin, Liu, Liu, Liu, Liu, Liu, López-Duarte, Ma, Ma, Medintz, Melnychuk, Miao, Monteiro, Naccarato, Nandi, Ng, Nie, Nooney, Ou, Pan, Pellegrino, Peng, Pompa, Potter, Qian, Qian, Qu, Rakovich, Rao, Reisch, Riccò, Riedinger, Ruedas-Rama, Saha, Samokhvalov, See, Shamirian, Shang, Shang, Shangguan, Shao, Shen, SMITH, Song, Stich, Stryer, Stöber, Su, Sun, Tang, Thiyagarajan, Toh, Ukeda, Valeur, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wei, Wen, Widengren, Wolfbeis, Wu, Wu, Wu, Wu, Wu, Xie, Xie, Xu, Xu, Yang, Yang, Ye, Yin, Yin, Yu, Yu, Yu, Zadran, Zeng, Zhang, Zhang, Zhang, Zhao, Zheng, Zhu, Zor, Zorman   +183 more
core   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Developmental assembly of multi-component polymer systems through interconnected synthetic gene networks in vitro

Nature Communications
Living cells regulate the dynamics of developmental events through interconnected signaling systems that activate and deactivate inert precursors. This suggests that similarly, synthetic biomaterials could be designed to develop over time by using ...
Daniela Sorrentino, Simona Ranallo, Francesco Ricci, Elisa Franco   +3 more
doaj   +1 more source

Thiamine Acquisition Strategies Impact Metabolism and Competition in the Gut Microbe Bacteroides thetaiotaomicron. [PDF]

, 2017
Thiamine (vitamin B1) is an essential cofactor for all organisms. Humans primarily acquire thiamine through their diet, and thiamine deficiencies have adverse neurological effects.
Costliow, Zachary A, Degnan, Patrick H
core  

Chromatin Laser Imaging Reveals Abnormal Nuclear Changes for Early Cancer Detection

, 2018
We developed and applied rapid scanning laser-emission microscopy to detect abnormal changes in cell nuclei for early diagnosis of cancer and cancer precursors.
Aslam, Muhammad Nadeem, Bergin, Ingrid, Chen, Grace, Chen, Qiushu, Chen, Yu-Cheng, Fan, Xudong, Tan, Xiaotain   +6 more
core   +1 more source