Results 141 to 150 of about 3,173,825 (322)

A Deep Search for Ethylene Glycol and Glycolonitrile in the V883 Ori Protoplanetary Disk

The Astrophysical Journal Letters
Ethylene glycol ( ${({{\rm{CH}}}_{2}{\rm{OH}})}_{2}$ ; hereafter EG) and glycolonitrile ( ${{\rm{HOCH}}}_{2}{\rm{CN}}$ ; hereafter GN) are considered molecular precursors of nucleic acids.
Abubakar M. A. Fadul, Kamber R. Schwarz, Tushar Suhasaria, Jenny K. Calahan, Jane Huang, Merel L. R. van ’t Hoff   +5 more
doaj   +1 more source

Competence development by Haemophilus influenzae is regulated by the availability of nucleic acid precursors

Molecular Microbiology, 2001
Leah P. Macfadyen, David D. Y. Chen, Hung C. Vo, D. Joshua Liao, Ryan Sinotte, R. Redfield   +5 more
semanticscholar   +1 more source

The Progress and Evolving Trends in Nucleic-Acid-Based Therapies

Nucleic-acid-based therapies have emerged as a pivotal domain within contemporary biomedical science, marked by significant advancements in recent years. These innovative treatments primarily operate through the precise binding of DNA or RNA molecules to
Chunmiao Wang, Mengtian Ren, Xiuping Fu, Yunlong Liu   +3 more
core   +1 more source

In Vitro Transcriptional Regulation via Nucleic-Acid-Based Transcription Factors

, 2019
Cells execute complex transcriptional programs by deploying distinct protein regulatory assemblies that interact with cis-regulatory elements throughout the genome. Using concepts from DNA nanotechnology, we synthetically recapitulated this feature in in
Leo Y. T. Chou (7499429), William M. Shih (1320471)   +1 more
core   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

STUDIES ON PRECURSORS OF PYRIMIDINES OF NUCLEIC ACID

Journal of Biological Chemistry, 1954
L L, WEED, D W, WILSON
openaire   +2 more sources

Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease

Advanced Science, EarlyView.
A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li, Xi Wan, Xinru Su, Zechuan Li, Yue Wang, Ying Wang, Ruofei Li, Huangzhao Wei, Jianbin Zhang, Shuai Wang   +9 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Nucleic Acids: Precursors and Products [PDF]

Nature, 1970
openaire   +1 more source

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source