Results 181 to 190 of about 437,756 (347)

Life's homochirality: Across a prebiotic network. [PDF]

Proc Natl Acad Sci U S A
Ozturk SF, Sasselov DD.
europepmc   +1 more source

In Vitro Antimalarial Activity of Nucleic Acid Precursor Analogues in the Simian Malaria Plasmodium knowlesi

, 1974
Gerald J. McCormick, Craig J. Canfield, Gloria P. Willet   +2 more
openalex   +2 more sources

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

A New Dual-Affinity Peptide Nucleic Acid for Targeting miRNA-21 Precursor Rescues Tumor Repressor PTEN Expression

Yun Lian, Anni Wang, Ruiyu Lin, Xin Ke, Xuan Zhan, Rongguang Lu, Tianwei Qian, Arpita Ghosh, Alan Ann Lerk Ong, Desiree‐Faye Kaixin Toh, Kiran M. Patil, Manchugondanahalli S. Krishna, Clément Dezanet, Jean‐Luc Décout, Souvik Maiti, Hongwei Wang, Gang Chen   +16 more
openalex   +2 more sources

Optimizing mRNA delivery with targeted elastin-like polypeptide-based LENN formulations: Insights into the endocytosis mechanism. [PDF]

Proc Natl Acad Sci U S A
Darji S, Qu F, Henager M, Prasad A, Elzey BD, Ferreira CR, Thompson DH.   +6 more
europepmc   +1 more source

A method for a selective local application of radioactive precursors of nucleic acids to the cow ovary [PDF]

, 1998
J. Pivko, P. Grafenau, V. Kopečný
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Beyond Traditional RAFT Polymerization: Emerging Strategies and Future Perspectives; A Third Update

Advanced Science, EarlyView.
This review explores recent advances in the past five years for non‐traditional RAFT polymerization, focusing on new activation strategies, sustainable depolymerization, and integration with automated and AI‐driven synthesis. Together, these innovations advance polymer chemistry and reveal how the pieces of the non‐traditional RAFT puzzle are steadily ...
Vianna F. Jafari, James L. Grace, Jiajia Li, Joji Tanaka, Glen R. Jones, Athina Anastasaki, Wei You, Jian Zhu, Masami Kamigaito, Cyrille Boyer, Greg G. Qiao   +10 more
wiley   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Transcriptome-wide analysis of Arabidopsis DICER-LIKE1 RNA substrates. [PDF]

Nucleic Acids Res
Bologna NG, Sarazin A, Schott G, Bouet A, Achkar NP, Moro B, Jay F, Chorostecki U, Devers EA, Voinnet O.   +9 more
europepmc   +1 more source