Results 211 to 220 of about 59,011 (249)
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Inhibitory effects of orotate on precursor incorporation into nucleic acids
Chemico-Biological Interactions, 1990The influence of orotic acid on the incorporation of precursors into nucleic acids was studied in mice and rats and in isolated cells. In vivo, orotate levels were modified by two diets which are known to increase the rate of pyrimidine nucleotide synthesis in rat liver.
M A, Lea, A, Luke, A, Assad, S, Ayyala
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Metabolism of caffeine to nucleic acid precursors in mammalian cells
Mutation Research, 1976Caffeine is rapidly metabolized in human and mouse cells in culture by de-methylation: within 1-3 h of exposure to millimolar concentrations of labeled caffeine, more than 90% of the pool consists of labeled products of metabolism and less than 10% is still caffeine. The methyl groups seem to be transferred and used in the de novo synthesis of thymine,
R, Goth, J E, Cleaver
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Synthesis of phage-precursor nucleic acid in the presence of chloramphenicol
Virology, 1957If chloramphenicol is added to a bacterial culture infected with T2 some minutes earlier, synthesis of phage nucleic acid proceeds with very little concomitant protein synthesis. If chloramphenicol is subsequently removed, phage particles promptly start to form, and the phosphorus of nucleic acid synthesized during the chloramphenicol period enters ...
A D, HERSHEY, N E, MELECHEN
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Peptide Nucleic Acids Targeted to the Amyloid Precursor Protein
Journal of Molecular Neuroscience, 2003The depositing in brain of amyloid beta peptide (Abeta), which is formed by the cleavage of amyloid precursor protein (APP), is likely an etiologic factor in Alzheimer's disease (AD). Of the different forms of Abeta, Abeta(1-42) causes fibril formation and increases aggregation at elevated levels, which can lead to neuronal death.
Beth M, McMahon +5 more
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Origins of life and evolution of the biosphere, 1987
Activated derivatives of purine-containing deoxynucleoside- diphosphates spontaneously oligomerize to produce pyrophosphate- linked oligodeoxynucleotide analogues. These analogues are of potential interest as models of primitive, polynucleotide precursors.
A W, Schwartz +3 more
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Activated derivatives of purine-containing deoxynucleoside- diphosphates spontaneously oligomerize to produce pyrophosphate- linked oligodeoxynucleotide analogues. These analogues are of potential interest as models of primitive, polynucleotide precursors.
A W, Schwartz +3 more
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A Second Pathway to Degrade Pyrimidine Nucleic Acid Precursors in Eukaryotes
Journal of Molecular Biology, 2008Pyrimidine bases are the central precursors for RNA and DNA, and their intracellular pools are determined by de novo, salvage and catabolic pathways. In eukaryotes, degradation of uracil has been believed to proceed only via the reduction to dihydrouracil.
G. Andersen +13 more
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The E. coli mRNA as a precursor for the T4 phage nucleic acids
Molecular and General Genetics MGG, 1974Labelling experiments with 14C-guanine have shown that the degradation products of E. coli mRNA are completely employed for the synthesis of T4 phage specific nucleic acids. Also, the host DNA labelling is completely recovered in the phage DNA whereas the stable RNA is quantitatively unaffected. Kinetic experiments lead to estimate the half life of the
P R, Vigier, H, Marcovich
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Entamoeba histolytica: Nucleic acid precursors affecting axenic growth
Experimental Parasitology, 1980Abstract Treatment of Panmede and Trypticase, in water, with activated carbon and subsequently combining the filtered solution with glucose, cysteine, salts, serum and vitamins results in a medium depleted in the nucleic acid precursors required to sustain a high level of growth of axenic Entamoeba histolytica.
R E, Reeves, B, West
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Biochemical Pharmacology, 1964
Abstract Subcutaneous injection of 1.0–1.l mg of colchicine/kg body weight into adult Sprague-Dawley rats 16–18 hr prior to the administration of radioactive nucleic acid precursors led to elevation over control values of the specific activities of the pyrimidines and purines of liver RNA.
H, WEINFELD, A A, SANDBERG
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Abstract Subcutaneous injection of 1.0–1.l mg of colchicine/kg body weight into adult Sprague-Dawley rats 16–18 hr prior to the administration of radioactive nucleic acid precursors led to elevation over control values of the specific activities of the pyrimidines and purines of liver RNA.
H, WEINFELD, A A, SANDBERG
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Incorporation studies of nucleic acid precursors in gastric cancer
Journal of Cancer Research and Clinical Oncology, 1979Measurements of the rate of incorporation of radioactively labeled nucleic acid precursors into the DNA and RNA of gastric carcinoma cell suspensions indicated variable rates of proliferation for the tumors. The rate of incorporation generally correlates to the cytological level of differentiation of the carcinoma. Reduced differentiation of the tumors
P, Schlag +4 more
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