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Origins of life and evolution of the biosphere, 1987
Activated derivatives of purine-containing deoxynucleoside- diphosphates spontaneously oligomerize to produce pyrophosphate- linked oligodeoxynucleotide analogues. These analogues are of potential interest as models of primitive, polynucleotide precursors.
A W, Schwartz +3 more
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Activated derivatives of purine-containing deoxynucleoside- diphosphates spontaneously oligomerize to produce pyrophosphate- linked oligodeoxynucleotide analogues. These analogues are of potential interest as models of primitive, polynucleotide precursors.
A W, Schwartz +3 more
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A Second Pathway to Degrade Pyrimidine Nucleic Acid Precursors in Eukaryotes
Journal of Molecular Biology, 2008Pyrimidine bases are the central precursors for RNA and DNA, and their intracellular pools are determined by de novo, salvage and catabolic pathways. In eukaryotes, degradation of uracil has been believed to proceed only via the reduction to dihydrouracil.
G. Andersen +13 more
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The E. coli mRNA as a precursor for the T4 phage nucleic acids
Molecular and General Genetics MGG, 1974Labelling experiments with 14C-guanine have shown that the degradation products of E. coli mRNA are completely employed for the synthesis of T4 phage specific nucleic acids. Also, the host DNA labelling is completely recovered in the phage DNA whereas the stable RNA is quantitatively unaffected. Kinetic experiments lead to estimate the half life of the
P R, Vigier, H, Marcovich
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Biochemical Pharmacology, 1964
Abstract Subcutaneous injection of 1.0–1.l mg of colchicine/kg body weight into adult Sprague-Dawley rats 16–18 hr prior to the administration of radioactive nucleic acid precursors led to elevation over control values of the specific activities of the pyrimidines and purines of liver RNA.
H, WEINFELD, A A, SANDBERG
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Abstract Subcutaneous injection of 1.0–1.l mg of colchicine/kg body weight into adult Sprague-Dawley rats 16–18 hr prior to the administration of radioactive nucleic acid precursors led to elevation over control values of the specific activities of the pyrimidines and purines of liver RNA.
H, WEINFELD, A A, SANDBERG
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Incorporation studies of nucleic acid precursors in gastric cancer
Journal of Cancer Research and Clinical Oncology, 1979Measurements of the rate of incorporation of radioactively labeled nucleic acid precursors into the DNA and RNA of gastric carcinoma cell suspensions indicated variable rates of proliferation for the tumors. The rate of incorporation generally correlates to the cytological level of differentiation of the carcinoma. Reduced differentiation of the tumors
P, Schlag +4 more
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Studies on the uptake of nucleic acid precursors into cells in tissue culture
Biochimica et Biophysica Acta (BBA) - General Subjects, 1968Abstract Persantin specifically inhibits the uptake of nucleosides and deoxynucleosides into tissue culture cells without interfering significantly with the uptake of free bases, formate and leucine, or with DNA, RNA and protein synthesis. The uptake of most of the nucleosides follows normal Michaelis-Menten kinetics.
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1984
The incorporation of the following nucleic acid precursors into nucleic acids of the microbial community from lake Großer Plöner See was measured, (methyl-3 H)thymidine, (5,6-3 H)uridine, (methyl-3H)thymine, (2-3H)adenine, (5-3H)orotic acid, L-(U-14C)aspartic acid, (U-14C)glycine, D-(l-14C)ribose and 32P phosphate.
Witzel, K., Graf, G.
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The incorporation of the following nucleic acid precursors into nucleic acids of the microbial community from lake Großer Plöner See was measured, (methyl-3 H)thymidine, (5,6-3 H)uridine, (methyl-3H)thymine, (2-3H)adenine, (5-3H)orotic acid, L-(U-14C)aspartic acid, (U-14C)glycine, D-(l-14C)ribose and 32P phosphate.
Witzel, K., Graf, G.
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Polynucleotide analogues as possible primitive precursors of nucleic acids
Origins of life and evolution of the biosphere, 1986Activated derivatives of purine-containing deoxynucleosidedimonophosphates spontaneously oligomerize to produce pyrophosphatelinked oligonucleotide analogues. These analogues are of potential interest as models of primitive, polynucleotide precursors.
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Xanthine as a precursor of nucleic acid purines in the mouse
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1965Pomales, R, Elion, G B, Hitchings, G H
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Assimilation of nucleic acid precursors by isolated thymus nuclei
Experimental Cell Research, 1959T R, BREITMAN, G C, WEBSTER
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