Results 261 to 270 of about 492,866 (322)
Some of the next articles are maybe not open access.
Biochemical Pharmacology, 1964
Abstract Subcutaneous injection of 1.0–1.l mg of colchicine/kg body weight into adult Sprague-Dawley rats 16–18 hr prior to the administration of radioactive nucleic acid precursors led to elevation over control values of the specific activities of the pyrimidines and purines of liver RNA.
H. Weinfeld, A. Sandberg
semanticscholar +3 more sources
Abstract Subcutaneous injection of 1.0–1.l mg of colchicine/kg body weight into adult Sprague-Dawley rats 16–18 hr prior to the administration of radioactive nucleic acid precursors led to elevation over control values of the specific activities of the pyrimidines and purines of liver RNA.
H. Weinfeld, A. Sandberg
semanticscholar +3 more sources
Assimilation of nucleic acid precursors by isolated thymus nuclei.
Experimental Cell Research, 1959T. Breitman, G. Webster
semanticscholar +3 more sources
Origins of life and evolution of the biosphere, 1987
Activated derivatives of purine-containing deoxynucleoside- diphosphates spontaneously oligomerize to produce pyrophosphate- linked oligodeoxynucleotide analogues. These analogues are of potential interest as models of primitive, polynucleotide precursors.
A W, Schwartz +3 more
openaire +2 more sources
Activated derivatives of purine-containing deoxynucleoside- diphosphates spontaneously oligomerize to produce pyrophosphate- linked oligodeoxynucleotide analogues. These analogues are of potential interest as models of primitive, polynucleotide precursors.
A W, Schwartz +3 more
openaire +2 more sources
Uptakein Vitro of nucleic acid precursors and nucleic acids by Zajdela ascitic hepatoma cells
The Journal of Membrane Biology, 1975Zajdela ascitic hepatoma cells are shown to take up pyrimidine bases at much lower rates than obtained in slices from normal rat liver. The rates of uptake of adenine and uridine by the Zajdela cells are, however, as high as in the slices. Like the slices, again, the Zajdela cells take up E.
P M, Bhargava +3 more
openaire +2 more sources
Peptide Nucleic Acids Targeted to the Amyloid Precursor Protein
Journal of Molecular Neuroscience, 2003The depositing in brain of amyloid beta peptide (Abeta), which is formed by the cleavage of amyloid precursor protein (APP), is likely an etiologic factor in Alzheimer's disease (AD). Of the different forms of Abeta, Abeta(1-42) causes fibril formation and increases aggregation at elevated levels, which can lead to neuronal death.
Beth M, McMahon +5 more
openaire +2 more sources
Inhibitory effects of orotate on precursor incorporation into nucleic acids
Chemico-Biological Interactions, 1990The influence of orotic acid on the incorporation of precursors into nucleic acids was studied in mice and rats and in isolated cells. In vivo, orotate levels were modified by two diets which are known to increase the rate of pyrimidine nucleotide synthesis in rat liver.
M A, Lea, A, Luke, A, Assad, S, Ayyala
openaire +2 more sources
Adenosylmethionine as a Precursor for Nucleic Acids Modification
1980Adenosylmethionine (Ado-Met) is the most important donor of alkyl groups, which are transferred from the sulfonium pole to a variety of nucleophilic molecular species within the cell1. The reaction involves nucleophilic attack to one of the three carbon atoms adjacent to the electron-deficient trivalent sulfur (see Figure 1) and is catalyzed by ...
SALVATORE, FRANCESCO +5 more
openaire +2 more sources
Nucleic acid precursor synthesis by Plasmodium lophurae parasitizing chicken erythrocytes
Experimental Parasitology, 1973Abstract Chicken erythrocytes parasitized by Plasmodium lophurae were cultured in vitro in the presence of glycine-2-14C, glycine-U-14C, and 14C-Na-formate for 10–16 hr. Purines isolated from the acid-soluble fraction (ASF), RNA and DNA of parasitized blood exposed to 14C-glycine contained specific activities equivalent to those of uninfected ...
T, Booden, R W, Hull
openaire +2 more sources
Synthesis of phage-precursor nucleic acid in the presence of chloramphenicol
Virology, 1957If chloramphenicol is added to a bacterial culture infected with T2 some minutes earlier, synthesis of phage nucleic acid proceeds with very little concomitant protein synthesis. If chloramphenicol is subsequently removed, phage particles promptly start to form, and the phosphorus of nucleic acid synthesized during the chloramphenicol period enters ...
A D, HERSHEY, N E, MELECHEN
openaire +2 more sources
Incorporation studies of nucleic acid precursors in gastric cancer
Journal of Cancer Research and Clinical Oncology, 1979Measurements of the rate of incorporation of radioactively labeled nucleic acid precursors into the DNA and RNA of gastric carcinoma cell suspensions indicated variable rates of proliferation for the tumors. The rate of incorporation generally correlates to the cytological level of differentiation of the carcinoma. Reduced differentiation of the tumors
P, Schlag +4 more
openaire +2 more sources