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Bioconjugate Chemistry, 2020
Quinone methide precursors 2 and 3 were protected with a photoreactive 2-nitrobenzyl group and conjugated to peptide nucleic acids (PNA) using a Huisgen click reaction. After brief irradiation at 365 nm, cross-linking with complementary RNA strands started and was analyzed with an ALFexpress sequencer. When this method was used, the gel temperature had
Jan-Erik Hornung +2 more
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Quinone methide precursors 2 and 3 were protected with a photoreactive 2-nitrobenzyl group and conjugated to peptide nucleic acids (PNA) using a Huisgen click reaction. After brief irradiation at 365 nm, cross-linking with complementary RNA strands started and was analyzed with an ALFexpress sequencer. When this method was used, the gel temperature had
Jan-Erik Hornung +2 more
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Down-Regulation of Amyloid Precursor Protein by Peptide Nucleic Acid In Vivo
Journal of Molecular Neuroscience, 2004Alzheimer's disease (AD) is a neurodegenerative disease associated with increased expression of amyloid precursor protein (APP) and the deposition of its proteolytic cleavage products, the amyloid-beta peptides, Abeta(1-40) and Abeta(1-42). Peptide nucleic acids (PNAs) have been shown to block the expression of proteins at transcriptional and ...
Mona, Boules +4 more
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Polynucleotide analogues as possible primitive precursors of nucleic acids
Origins of life and evolution of the biosphere, 1986Activated derivatives of purine-containing deoxynucleosidedimonophosphates spontaneously oligomerize to produce pyrophosphatelinked oligonucleotide analogues. These analogues are of potential interest as models of primitive, polynucleotide precursors.
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Carboranyl Precursors of Nucleic Acids--Potential DNA Probes for BNCT
1992It has been determined that the biological effectiveness of BNCT will be maximized if the capture reaction were to occur in the cell nucleus in comparison with the cytoplasm, on cell membrane or in extracellular spaces.1–2 This has been the basis for the ongoing synthesis of boron compounds which are chemically similar to the building blocks of the ...
A. H. Soloway +5 more
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Uptake of nucleic acid, protein and carbohydrate precursors by hen-oviduct lipids
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1965Abstract 1. 1. The incorporation of radioactive materials suspected of being present in various amino acid-containing lipid fractions was tested. After simultaneous double isotope incubations, the lipids were fractionated in different chromatographic systems and assayed for the incorporation of each type of radioactive label.
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Altered incorporation of nucleic acid precursors by mycoplasma-infected mammalian cells in culture.
Experimental Cell Research, 1972A. Perez +3 more
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The in vitro uptake of tritiated nucleic acid precursors by Babesia spp. of cattle and mice.
International Journal of Parasitology, 1978A. Irvin, E. R. Young, R. Purnell
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Studies on the uptake of nucleic acid precursors into cells in tissue culture.
Biochimica et Biophysica Acta, 1968Christoph Scholtissek
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1984
The incorporation of the following nucleic acid precursors into nucleic acids of the microbial community from lake Großer Plöner See was measured, (methyl-3 H)thymidine, (5,6-3 H)uridine, (methyl-3H)thymine, (2-3H)adenine, (5-3H)orotic acid, L-(U-14C)aspartic acid, (U-14C)glycine, D-(l-14C)ribose and 32P phosphate.
Witzel, K., Graf, G.
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The incorporation of the following nucleic acid precursors into nucleic acids of the microbial community from lake Großer Plöner See was measured, (methyl-3 H)thymidine, (5,6-3 H)uridine, (methyl-3H)thymine, (2-3H)adenine, (5-3H)orotic acid, L-(U-14C)aspartic acid, (U-14C)glycine, D-(l-14C)ribose and 32P phosphate.
Witzel, K., Graf, G.
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