Results 291 to 300 of about 437,756 (347)
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Uptakein Vitro of nucleic acid precursors and nucleic acids by Zajdela ascitic hepatoma cells
The Journal of Membrane Biology, 1975Zajdela ascitic hepatoma cells are shown to take up pyrimidine bases at much lower rates than obtained in slices from normal rat liver. The rates of uptake of adenine and uridine by the Zajdela cells are, however, as high as in the slices. Like the slices, again, the Zajdela cells take up E.
P M, Bhargava +3 more
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Peptide Nucleic Acids Targeted to the Amyloid Precursor Protein
Journal of Molecular Neuroscience, 2003The depositing in brain of amyloid beta peptide (Abeta), which is formed by the cleavage of amyloid precursor protein (APP), is likely an etiologic factor in Alzheimer's disease (AD). Of the different forms of Abeta, Abeta(1-42) causes fibril formation and increases aggregation at elevated levels, which can lead to neuronal death.
Beth M, McMahon +5 more
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Modifications of Nucleic Acid Precursors That Inhibit Plant Virus Multiplication
Phytopathology, 1987W. Dawson, C. Boyd
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Inhibitory effects of orotate on precursor incorporation into nucleic acids
Chemico-Biological Interactions, 1990The influence of orotic acid on the incorporation of precursors into nucleic acids was studied in mice and rats and in isolated cells. In vivo, orotate levels were modified by two diets which are known to increase the rate of pyrimidine nucleotide synthesis in rat liver.
M A, Lea, A, Luke, A, Assad, S, Ayyala
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Adenosylmethionine as a Precursor for Nucleic Acids Modification
1980Adenosylmethionine (Ado-Met) is the most important donor of alkyl groups, which are transferred from the sulfonium pole to a variety of nucleophilic molecular species within the cell1. The reaction involves nucleophilic attack to one of the three carbon atoms adjacent to the electron-deficient trivalent sulfur (see Figure 1) and is catalyzed by ...
SALVATORE, FRANCESCO +5 more
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Nucleic acid precursor synthesis by Plasmodium lophurae parasitizing chicken erythrocytes
Experimental Parasitology, 1973Abstract Chicken erythrocytes parasitized by Plasmodium lophurae were cultured in vitro in the presence of glycine-2-14C, glycine-U-14C, and 14C-Na-formate for 10–16 hr. Purines isolated from the acid-soluble fraction (ASF), RNA and DNA of parasitized blood exposed to 14C-glycine contained specific activities equivalent to those of uninfected ...
T, Booden, R W, Hull
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Synthesis of phage-precursor nucleic acid in the presence of chloramphenicol
Virology, 1957If chloramphenicol is added to a bacterial culture infected with T2 some minutes earlier, synthesis of phage nucleic acid proceeds with very little concomitant protein synthesis. If chloramphenicol is subsequently removed, phage particles promptly start to form, and the phosphorus of nucleic acid synthesized during the chloramphenicol period enters ...
A D, HERSHEY, N E, MELECHEN
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Bioconjugate Chemistry, 2020
Quinone methide precursors 2 and 3 were protected with a photoreactive 2-nitrobenzyl group and conjugated to peptide nucleic acids (PNA) using a Huisgen click reaction. After brief irradiation at 365 nm, cross-linking with complementary RNA strands started and was analyzed with an ALFexpress sequencer. When this method was used, the gel temperature had
Jan-Erik Hornung +2 more
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Quinone methide precursors 2 and 3 were protected with a photoreactive 2-nitrobenzyl group and conjugated to peptide nucleic acids (PNA) using a Huisgen click reaction. After brief irradiation at 365 nm, cross-linking with complementary RNA strands started and was analyzed with an ALFexpress sequencer. When this method was used, the gel temperature had
Jan-Erik Hornung +2 more
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Down-Regulation of Amyloid Precursor Protein by Peptide Nucleic Acid In Vivo
Journal of Molecular Neuroscience, 2004Alzheimer's disease (AD) is a neurodegenerative disease associated with increased expression of amyloid precursor protein (APP) and the deposition of its proteolytic cleavage products, the amyloid-beta peptides, Abeta(1-40) and Abeta(1-42). Peptide nucleic acids (PNAs) have been shown to block the expression of proteins at transcriptional and ...
Mona, Boules +4 more
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Biochemical Pharmacology, 1964
Abstract Subcutaneous injection of 1.0–1.l mg of colchicine/kg body weight into adult Sprague-Dawley rats 16–18 hr prior to the administration of radioactive nucleic acid precursors led to elevation over control values of the specific activities of the pyrimidines and purines of liver RNA.
H, WEINFELD, A A, SANDBERG
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Abstract Subcutaneous injection of 1.0–1.l mg of colchicine/kg body weight into adult Sprague-Dawley rats 16–18 hr prior to the administration of radioactive nucleic acid precursors led to elevation over control values of the specific activities of the pyrimidines and purines of liver RNA.
H, WEINFELD, A A, SANDBERG
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