SNBRFinder: A Sequence-Based Hybrid Algorithm for Enhanced Prediction of Nucleic Acid-Binding Residues. [PDF]
PLoS ONE, 2015 Protein-nucleic acid interactions are central to various fundamental biological processes. Automated methods capable of reliably identifying DNA- and RNA-binding residues in protein sequence are assuming ever-increasing importance.
Xiaoxia Yang +3 more
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Nucleic acid-based therapy for coronavirus disease 2019
Heliyon, 2020 The coronavirus disease 2019 (COVID-19), the pandemic that originated in China has already spread into more than 190 countries, resulting in huge loss of human life and many more are at the stake of losing it; if not intervened with the best therapeutics
Ravikant Piyush +4 more
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Machine Learning Guides Peptide Nucleic Acid Flow Synthesis and Sequence Design
Advanced Science, 2022 Peptide nucleic acids (PNAs) are potential antisense therapies for genetic, acquired, and viral diseases. Efficiently selecting candidate PNA sequences for synthesis and evaluation from a genome containing hundreds to thousands of options can be ...
Chengxi Li +6 more
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Synthesis and Biological Properties of Caffeic Acid-PNA Dimers Containing Guanine
Molecules, 2013 Caffeic acid (CA; 3,4-dihydroxycinnamic acid) is endowed with high antioxidant activity. CA derivatives (such as amides) have gained a lot of attention due to their antioxidative, antitumor and antimicrobial properties as well as stable characteristics ...
Antonio Fiorentino +7 more
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Pyrene-modified PNAs: Stacking interactions and selective excimer emission in PNA2DNA triplexes
Beilstein Journal of Organic Chemistry, 2014 Pyrene derivatives can be incorporated into nucleic acid analogs in order to obtain switchable probes or supramolecular architectures. In this paper, peptide nucleic acids (PNAs) containing 1 to 3 1-pyreneacetic acid units (PNA1–6) with a sequence with ...
Alex Manicardi +3 more
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A Comparative Evaluation of Indirect Sequence-Specific Magnetoextraction-aided Fluorescence and Electrochemical LAMP with SARS-CoV-2 Nucleic Acid as the Analyte [PDF]
, 2022 Sayantan Tripathy +5 more
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Computer programs for nucleic acid sequence manipulation [PDF]
Nucleic Acids Research, 1982 Computer programs are described which help during the collection and analysis of nucleic acid sequence data. They are written in FORTRAN and have been implemented on a PDP 11/60 computer.
R M, Blumenthal, P J, Rice, R J, Roberts
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By-product formation in repetitive PCR amplification of DNA libraries during SELEX. [PDF]
PLoS ONE, 2014 The selection of nucleic acid aptamers is an increasingly important approach to generate specific ligands binding to virtually any molecule of choice. However, selection-inherent amplification procedures are prone to artificial by-product formation that ...
Fabian Tolle +3 more
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Model-directed generation of CRISPR-Cas13a guide RNAs designs artificial sequences that improve nucleic acid detection [PDF]
, 2023 Sreekar Mantena +6 more
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CAP: Commutative algebra prediction of protein-nucleic acid binding affinities
Machine Learning: Science and TechnologyAn accurate prediction of protein-nucleic acid binding affinity is vital for deciphering genomic processes, yet existing approaches often struggle in reconciling high accuracy with interpretability and computational efficiency.
Mushal Zia +5 more
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