Results 91 to 100 of about 775,236 (354)
Flexibility of nucleic acids: from DNA to RNA [PDF]
arXiv, 2015 The structural flexibility of nucleic acids plays a key role in many fundamental life processes, such as gene replication and expression, DNA-protein recognition, and gene regulation. To obtain a thorough understanding of nucleic acid flexibility, extensive studies have been performed using various experimental methods and theoretical models.
arxiv
Inverted and mirror repeats in model nucleotide sequences [PDF]
, 2007 We analytically and numerically study the probabilistic properties of inverted and mirror repeats in model sequences of nucleic acids. We consider both perfect and non-perfect repeats, i.e. repeats with mismatches and gaps. The considered sequence models are independent identically distributed (i.i.d.) sequences, Markov processes and long range ...
arxiv +1 more source
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Pyrene-modified PNAs: Stacking interactions and selective excimer emission in PNA2DNA triplexes
Beilstein Journal of Organic Chemistry, 2014 Pyrene derivatives can be incorporated into nucleic acid analogs in order to obtain switchable probes or supramolecular architectures. In this paper, peptide nucleic acids (PNAs) containing 1 to 3 1-pyreneacetic acid units (PNA1–6) with a sequence with ...
Alex Manicardi +3 more
doaj +1 more source
Molecules, 2017 In this review, we summarize the recent advances in the use of pyrene-modified oligonucleotides as a platform for functional nucleic acid-based constructs.
Olga A. Krasheninina +3 more
doaj +1 more source
An extra dimension in nucleic acid sequence recognition
Quarterly Reviews of Biophysics, 2005 Introduction 312Triple helices in DNA 312Chemically modified TFOs 313Further development 316Recognition of GC base pairs 316Recognition of TA base pairs 316Recognition of AT base pairs 317Recognition of CG base pairs 317RNA triplexes 317Kinetics of triplex formation 318Practical applications of triplexes 318Conclusions 319References 319Watson–Crick ...
Fox, Keith R., Brown, Tom
openaire +4 more sources
ENA as an Information Hub [PDF]
, 2010 The European Nucleotide Archive (ENA; "http://www.ebi.ac.uk/ena/":http://www.ebi.ac.uk/ena/) is a comprehensive repository for public nucleotide sequence data from nearly four hundred thousand taxonomic nodes.
Bob Vaughan +5 more
core +2 more sources
The roles and applications of extracellular vesicles in cancer
Molecular Oncology, EarlyView.Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley +1 more source
A CRISPR-based nucleic acid detection method for severe fever with thrombocytopenia syndrome virus
Virus Research, 2022 Objective: Fever with thrombocytopenia syndrome virus (SFTS) is a tick-borne infection now known to spread among humans as an aerosol, which has resulted in several outbreaks across Asia over the past decade.
Yansong Zhang +15 more
doaj
Isothermal Amplification Methods for the Detection of Nucleic Acids in Microfluidic Devices
Biosensors, 2012 Diagnostic tools for biomolecular detection need to fulfill specific requirements in terms of sensitivity, selectivity and high-throughput in order to widen their applicability and to minimize the cost of the assay.
Giuseppe Spoto, Laura Maria Zanoli
doaj +1 more source