Results 91 to 100 of about 1,295,417 (401)

SNBRFinder: A Sequence-Based Hybrid Algorithm for Enhanced Prediction of Nucleic Acid-Binding Residues. [PDF]

PLoS ONE, 2015
Protein-nucleic acid interactions are central to various fundamental biological processes. Automated methods capable of reliably identifying DNA- and RNA-binding residues in protein sequence are assuming ever-increasing importance.
Xiaoxia Yang, Jia Wang, Jun Sun, Rong Liu   +3 more
doaj   +1 more source

PubDNA Finder in a Nutshell. Searching the Life Sciences Literature with Sequences of Nucleic Acids [PDF]

, 2011
Biomedical researchers and clinicians working with molecular technologies in routine clinical practice often need to review the available literature to gather information regarding specific sequences of nucleic acids. This includes, for instance, finding
García Remesal, Miguel
core   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Advanced Nanotechnology-Based Nucleic Acid Medicines

Pharmaceutics
Nucleic acid medicines are a highly attractive modality that act in a sequence-specific manner on target molecules. To date, 21 such products have been approved by the Food and Drug Administration.
Noriko Miyamoto, Mina Sakuragi, Yukio Kitade   +2 more
doaj   +1 more source

Recent advances and challenges of the use of the CRISPR/Cas system as a non-nucleic acid molecular diagnostic

Heliyon, 2023
The clustered regularly interspaced short palindromic DNA sequence repeats (CRISPR) and CRISPR-associated (Cas) (CRISPR/Cas) systems are currently applied not only as a gene editing tool but also as a novel molecular diagnostic technique.
Jian Zhou, Xue-mei Ren, Xin Wang, Zhuo Li, Cory J Xian   +4 more
doaj  

A Study of the Detection of SARS-CoV-2 ORF1ab Gene by the Use of Electrochemiluminescent Biosensor Based on Dual-Probe Hybridization

Sensors, 2022
To satisfy the need to develop highly sensitive methods for detecting the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and further enhance detection efficiency and capability, a new method was created for detecting SARS-CoV-2 of the ...
Chunying Jiang, Xihui Mu, Shuai Liu, Zhiwei Liu, Bin Du, Jiang Wang, Jianjie Xu   +6 more
doaj   +1 more source

Correlation between nucleotide composition and folding energy of coding sequences with special attention to wobble bases [PDF]

, 2008
Background: The secondary structure and complexity of mRNA influences its accessibility to regulatory molecules (proteins, micro-RNAs), its stability and its level of expression.
AA Komar, AA Komar, C Kimchi-Sarfaty, C Soares, C Workman, DE Draper, DJ Patterson, EG Shaper, EG Shpaer, F Pagani, GD Stormo, IM Meyer, J Duan, J Konecny, Jan C Biro, JC Biro, JC Biro, JC Biro, JC Biro, JC Biro, JD Lieb, JR Powell, JV Chamary, K Mita, K Robison, KB Nielsen, L Cartegni, L Katz, M Jia, M Kellis, M Oresic, M Oresic, M Zama, M Zuker, M Zuker, MD Ermolaeva, NR Markham, P Cortazzo, P Mukhopadhyay, S Itzkovitz, SA Shabalina, W Gu, W Gu, W Seffens, W Seffens, WC Winkler, ZE Sauna   +46 more
core   +4 more sources

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Synthesis and Biological Properties of Caffeic Acid-PNA Dimers Containing Guanine

Molecules, 2013
Caffeic acid (CA; 3,4-dihydroxycinnamic acid) is endowed with high antioxidant activity. CA derivatives (such as amides) have gained a lot of attention due to their antioxidative, antitumor and antimicrobial properties as well as stable characteristics ...
Antonio Fiorentino, Luigi Russo, Brigida D'Abrosca, Valeria Severino, Severina Pacifico, Gaetano Malgieri, Maria Gaglione, Anna Messere   +7 more
doaj   +1 more source

Towards Joint Sequence-Structure Generation of Nucleic Acid and Protein Complexes with SE(3)-Discrete Diffusion [PDF]

arXiv, 2023
Generative models of macromolecules carry abundant and impactful implications for industrial and biomedical efforts in protein engineering. However, existing methods are currently limited to modeling protein structures or sequences, independently or jointly, without regard to the interactions that commonly occur between proteins and other ...
arxiv