Results 111 to 120 of about 694,635 (336)

Robust self-replication of combinatorial information via crystal growth and scission [PDF]

, 2012
Understanding how a simple chemical system can accurately replicate combinatorial information, such as a sequence, is an important question for both the study of life in the universe and for the development of evolutionary molecular design techniques ...
B. Yurke, Bullard, Cairns-Smith, Carnall, Collins, Deck, Dutta, E. Winfree, Huppa, Johnston, Knowles, Mao, Orgel, Paul, R. Schulman, Rasmussen, Rothemund, Rothemund, Rubinov, Schrum, Seeman, Smalley, Smith, Viedma, Wang, Wang, Winfree, Wochner   +27 more
core   +3 more sources

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

G-quadruplex formation of FXYD1 pre-mRNA indicates the possiblity of regulating expression of its protein product [PDF]

, 2014
G-quadruplexes are higher-order nucleic acid structures formed of square-planar arrangements of four guanine bases held together by Hoogsteen-type hydrogen bonds. Stacks of guanine tetrads are stabilised by intercalating potassium ions. FXYD1 encodes for
Baydoun, A. R., Dhayan, Hansraj, Kukol, A.   +2 more
core   +1 more source

High‐Throughput Microfluidic‐Mediated Assembly of Layer‐By‐Layer Nanoparticles

Advanced Functional Materials, EarlyView.
The layer‐by‐layer (LbL) assembly of polymer films on nanoparticle (NP) surfaces is a promising technique for targeted drug delivery. Despite its success in preclinical mouse models, a current good manufacturing practices (cGMP) compliant, clinical‐scale production method has been lacking.
Ivan S. Pires, Ezra Gordon, Heikyung Suh, Darrell J. Irvine, Paula T. Hammond   +4 more
wiley   +1 more source

Buckyballs conjugated with nucleic acid sequences identifies microorganisms in live cell assays

Journal of Nanobiotechnology, 2017
Background Rapid identification of bacteria can play an important role at the point of care, evaluating the health of the ecosystem, and discovering spatiotemporal distributions of a bacterial community.
Qingsu Cheng, Bahram Parvin
doaj   +1 more source

NUCLEIC ACID SEQUENCE PHYLOGENY AND RANDOM OUTGROUPS

Cladistics, 1990
Abstract— When divergent taxa are used to root networks, it is assumed that the character stales in the outgroup have historical similarity to those in the ingroup. Yet, if the data are nucleic acid sequences, the character stales shared by a divergent outgroup may be based not on history but on random similarity. A simple procedure is proposed to test
openaire   +4 more sources

Identifying Interaction Sites in "Recalcitrant" Proteins: Predicted Protein and Rna Binding Sites in Rev Proteins of Hiv-1 and Eiav Agree with Experimental Data [PDF]

, 2005
Protein-protein and protein nucleic acid interactions are vitally important for a wide range of biological processes, including regulation of gene expression, protein synthesis, and replication and assembly of many viruses.
Carpenter, Susan, Dobbs, Drena, Dobbs, Drena, Honavar, Vasant, Jernigan, Robert, Jernigan, Robert, Lee, Jae-Hyung, Terribilini, Michael, Yan, Changhui   +8 more
core   +3 more sources

Protein-RNA interactions: a structural analysis [PDF]

, 2001
A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Berman, HM, Daley, DT, Jones, S, Luscombe, NM, Thornton, JM   +4 more
core   +2 more sources

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

DoubleHelix: nucleic acid sequence identification, assignment and validation tool for cryo-EM and crystal structure models. [PDF]

Nucleic Acids Res, 2023
Chojnowski G.
europepmc   +1 more source