Results 151 to 160 of about 376,743 (310)

A Sensitivity Study for Interpreting Nucleic Acid Sequence Screening Regulatory and Guidance Documentation: Toward a Foundational Synthetic Nucleic Acid Sequence Screening Framework. [PDF]

Appl Biosaf
Gemler BT, Mukherjee C, Fullerton PA, Diggans J, Bartling C.   +4 more
europepmc   +1 more source

Sequence-Specific Covalent Capture Coupled with High-Contrast Nanopore Detection of a Disease-Derived Nucleic Acid Sequence. [PDF]

Chembiochem, 2017
Nejad MI, Shi R, Zhang X, Gu LQ, Gates KS.   +4 more
europepmc   +1 more source

Statistical characterization of nucleic acid sequence functional domains [PDF]

, 1983
Temple F. Smith, Michael S. Waterman, John R. Sadler   +2 more
openalex   +1 more source

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

Evolution of an Enzyme from a Noncatalytic Nucleic Acid Sequence. [PDF]

Sci Rep, 2015
Gysbers R, Tram K, Gu J, Li Y.
europepmc   +1 more source

N‐(2‐Hydroxyethyl)phenazinium derivatives of oligonucleotides as effectors of the sequence‐specific modification of nucleic acids with reactive oligonucleotide derivatives [PDF]

, 1988
Igor V. Kutyavin, M. A. Podyminogin, Yu.N. Bazhina, Olga S. Fedorova, D.G. Knorre, А. С. Левина, S.V. Mamayev, В. Ф. Зарытова   +7 more
openalex   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Split Dapoxyl Aptamer for Sequence-Selective Analysis of Nucleic Acid Sequence Based Amplification Amplicons. [PDF]

Anal Chem, 2019
Kikuchi N, Reed A, Gerasimova YV, Kolpashchikov DM.   +3 more
europepmc   +1 more source

Serology in the Digital Age: Using Long Synthetic Peptides Created from Nucleic Acid Sequences as Antigens in Microarrays [PDF]

, 2016
Muhammad Rizwan, Bengt Rönnberg, Maksims Čistjakovs, Åke Lundkvist, Rüdiger Pipkorn, Jonas Blomberg   +5 more
openalex   +1 more source

DNA Origami‐Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity

Advanced Materials, EarlyView.
Aptamers displayed on tubular DNA origami nanostructures in defined chiral orientations (left‐ or right‐handed) exhibit enantioselective interactions with cell surface target proteins. While the right‐handed configuration supports only transient binding, the left handedness energetically favors protein dimerization and promotes subsequent ...
Tingjie Song, Abhisek Dwivedy, Dhanush Gandavadi, Gayatri Chandran, Yiquan An, Mengxi Zheng, Xiaojing Wang, Lifeng Zhou, Yang Zhao, Xing Wang   +9 more
wiley   +1 more source