Results 161 to 170 of about 1,295,417 (401)

Large-Scale Multi-omic Biosequence Transformers for Modeling Protein-Nucleic Acid Interactions [PDF]

open access: yesarXiv
The transformer architecture has revolutionized bioinformatics and driven progress in the understanding and prediction of the properties of biomolecules. To date, most biosequence transformers have been trained on a single omic-either proteins or nucleic acids and have seen incredible success in downstream tasks in each domain with particularly ...
arxiv  

The study of water shell structure of double-helical B-DNA fragments using parallel computing [PDF]

open access: yesarXiv, 2014
Something about structure of the water shell of DNA and how it can help to design of novel biologically-active molecules and potential drugs with sequence-specific binding to nucleic acids.
arxiv  

A transgenic plant having enhanced drought tolerance [PDF]

open access: yes
The present invention relates to the field of transgenic plants with novel phenotypes, especially plants with enhanced drought and pathogen resistance.
Aharoni, A.   +4 more
core  

Engineered Chitosan‐Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons

open access: yesAdvanced Healthcare Materials, EarlyView.
This study introduces a novel chitosan‐based nanocarrier functionalized with a neurotropic protein for efficient siRNA delivery to neurons. The polyplexes demonstrate enhanced neuronal binding, retrograde transport, and PTEN silencing, promoting axonal outgrowth.
Ana P. Spencer   +10 more
wiley   +1 more source

ForCon : a software tool for the conversion of sequence alignments [PDF]

open access: yes, 1999
ForCon is a software tool for the conversion of nucleic acid and amino acid sequence alignments that runs on IBMcompatible computers under a Microsoft Windows environment.The program converts alignment formats used by all popular software packages for ...
Raes, Jeroen, Van de Peer, Yves
core   +1 more source

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

open access: yesAdvanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan   +3 more
wiley   +1 more source

Nucleic acid-based therapy for coronavirus disease 2019

open access: yesHeliyon, 2020
The coronavirus disease 2019 (COVID-19), the pandemic that originated in China has already spread into more than 190 countries, resulting in huge loss of human life and many more are at the stake of losing it; if not intervened with the best therapeutics
Ravikant Piyush   +4 more
doaj  

Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications

open access: yesAdvanced Healthcare Materials, EarlyView.
Nanomaterial integration transforms biosensor capabilities through enhanced signal transduction, sensitivity, and selectivity. This review analyzes how nanoscale materials—from nanoparticles to nanosheets—leverage unique physicochemical properties to revolutionize electrochemical, optical, and electrical biosensing.
Younghak Cho   +3 more
wiley   +1 more source

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