Nucleic acid sequence similarities: ‘Poly(A) tendency’
FEBS Letters, 1980 The origin and evolution of viruses is coming under stronger attack, thanks to the increasing availability of gene and genome sequences. However, the methodology is still narrow, being mainly based on alignment of sequences. In this paper I continue the effort to develop indexes for characterizing nucleic acid sequences and establishing relatedness ...
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Topological Machine Learning for Protein-Nucleic Acid Binding Affinity Changes Upon Mutation [PDF]
arXivUnderstanding how protein mutations affect protein-nucleic acid binding is critical for unraveling disease mechanisms and advancing therapies. Current experimental approaches are laborious, and computational methods remain limited in accuracy. To address this challenge, we propose a novel topological machine learning model (TopoML) combining persistent
arxiv
A new formalism for calculation of the partition function of single stranded nucleic acids [PDF]
arXiv, 2005 A new formalism for calculation of the partition function of single stranded nucleic acids is presented. Secondary structures and the topology of structure elements are the level of resolution that is used. The folding model deals with matches, mismatches, symmetric and asymmetric interior loops, stacked pairs in loop and dangling end regions, multi ...
arxiv
Methods and compositions for enhanced resistance to abiotic stress in plants [PDF]
, 2018 The present invention provides transgenic plants having increased tolerance to abiotic stress comprising a recombinant nucleic acid molecule, said recombinant nucleic acid molecule comprising a nucleotide sequence encoding miR319 operatively associated ...
Hu, Qian +3 more
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Search for nucleic acid sequences complementary to a murine oncornaviral genome in poly(A)-rich RNA of human leukemic cells. [PDF]
, 1975 Christian‐Jacques Larsen +5 more
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Advanced Healthcare Materials, EarlyView.Engineered exosome‐based heavy atom‐free nanosensitizers are developed for safe and targeted sono‐photodynamic therapy of solid tumors. The IR820‐TPE‐loaded, biotin‐conjugated exosomes (IR820‐TPE@B‐Exo) demonstrate significant promise for NIR fluorescence imaging‐guided sono‐photodynamic cancer therapy.
Van‐Nghia Nguyen +16 more
wiley +1 more source
Sequence programmable nucleic acid coacervates
AbstractNature uses bottom-up self-assembly to build structures with remarkable complexity and functionality. Understanding how molecular-scale interactions translate to macroscopic properties remains a major challenge and requires systems that effectively bridge these two scales.
Sumit Majumder +3 more
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Rosetta Brains: A Strategy for Molecularly-Annotated Connectomics [PDF]
arXiv, 2014 We propose a neural connectomics strategy called Fluorescent In-Situ Sequencing of Barcoded Individual Neuronal Connections (FISSEQ-BOINC), leveraging fluorescent in situ nucleic acid sequencing in fixed tissue (FISSEQ). FISSEQ-BOINC exhibits different properties from BOINC, which relies on bulk nucleic acid sequencing.
arxiv
Meeting review : ESF workshop on "Impact of nucleic acid chemistry on gene function analysis: antisense, aptamers, ribozymes and RNAi" [PDF]
, 2008 The shortage of functional information compared to the abundance of sequence information characterizes today’s situation in functional genomics. For many years the knock-down of a gene’s product has been the most powerful way of analysing its function ...
Engels, Joachim W. (Prof. Dr.) +3 more
core
MouseV k gene classification by nucleic acid sequence similarity [PDF]
, 1989 Robert Strohal +3 more
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