Helicase processivity and not the unwinding velocity exhibits universal increase with force [PDF]
, 2015 Helicases, involved in a number of cellular functions, are motors that translocate along singlestranded nucleic acid and couple the motion to unwinding double-strands of a duplex nucleic acid.
Chakrabarti, Shaon +2 more
core +3 more sources
Secondary structure formation of homopolymeric single-stranded nucleic acids including force and loop entropy: implications for DNA hybridization [PDF]
arXiv, 2011 Loops are essential secondary structure elements in folded DNA and RNA molecules and proliferate close to the melting transition. Using a theory for nucleic acid secondary structures that accounts for the logarithmic entropy c ln m for a loop of length m,
Einert, Thomas R. +2 more
core +2 more sources
Protein-Based Anchoring Methods for Nucleic Acid Detection in Lateral Flow Format Assays
Micromachines, 2023 The use of lateral flow assays to detect nucleic acid targets has many applications including point-of-care diagnostics, environmental monitoring, and food safety.
Kira Hallerbach +6 more
doaj +1 more source
Biosensors, 2021 Enteroviruses are ubiquitous mammalian pathogens that can produce mild to life-threatening disease. We developed a multimodal, rapid, accurate and economical point-of-care biosensor that can detect nucleic acid sequences conserved amongst 96% of all ...
Veeren M. Chauhan +5 more
doaj +1 more source
NASCUP: Nucleic Acid Sequence Classification by Universal Probability
IEEE Access, 2021 Nucleic acid sequence classification is a fundamental task in the field of bioinformatics. Due to the increasing amount of unlabeled nucleotide sequences, fast and accurate classification of them on a large scale has become crucial.
Sunyoung Kwon +5 more
doaj +1 more source
Optimization of Nucleic Acid Sequences [PDF]
Biophysical Journal, 2000 Base sequence influences the structure, mechanics, dynamics, and interactions of nucleic acids. However, studying all possible sequences for a given fragment leads to a number of base combinations that increases exponentially with length. We present here a novel methodology based on a multi-copy approach enabling us to determine which base sequence ...
Ingrid Lafontaine, Richard Lavery
openaire +3 more sources
Argonaute protein-based nucleic acid detection technology
Frontiers in Microbiology, 2023 It is vital to diagnose pathogens quickly and effectively in the research and treatment of disease. Argonaute (Ago) proteins are recently discovered nucleases with nucleic acid shearing activity that exhibit specific recognition properties beyond CRISPR ...
Zhiyun Wu +3 more
doaj +1 more source
Sequence-Specific Sensing of Nucleic Acids [PDF]
Trends in Immunology, 2017 Innate immune cells are endowed with many nucleic acid receptors, but the role of sequence in the detection of foreign organisms remains unclear. Can sequence patterns influence recognition? In addition, how can we infer those patterns from sequence data?
Benjamin Greenbaum +2 more
openaire +3 more sources
Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization
Pharmaceutics, 2020 In nature, genomes have been optimized by the evolution of their nucleic acid sequences. The design of peptide-like carriers as synthetic sequences provides a strategy for optimizing multifunctional targeted nucleic acid delivery in an iterative process.
Yanfang Wang, Ernst Wagner
doaj +1 more source
Analysis of Nucleotide Sequences Similarity and Protein Prediction of Some Resistance Genes in Escherichia coli Isolated from Iraqi Patients with Urinary Tract Infections [PDF]
Archives of Razi Institute, 2022 Antibiotic resistance leads to a dramatic increase in the morbidity and mortality caused by infectious diseases. Even though estimates vary widely, the economic cost of antimicrobial-resistant bacteria is on a rise.
R Kadhim Mohammed, A Attallah Ibrahim
doaj +1 more source