Results 11 to 20 of about 709,713 (351)
Optimization of Nucleic Acid Sequences [PDF]
Biophysical Journal, 2000 Base sequence influences the structure, mechanics, dynamics, and interactions of nucleic acids. However, studying all possible sequences for a given fragment leads to a number of base combinations that increases exponentially with length. We present here a novel methodology based on a multi-copy approach enabling us to determine which base sequence ...
Ingrid Lafontaine, Richard Lavery
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Argonaute protein-based nucleic acid detection technology
Frontiers in Microbiology, 2023 It is vital to diagnose pathogens quickly and effectively in the research and treatment of disease. Argonaute (Ago) proteins are recently discovered nucleases with nucleic acid shearing activity that exhibit specific recognition properties beyond CRISPR ...
Zhiyun Wu +3 more
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Sequence-Specific Sensing of Nucleic Acids [PDF]
Trends in Immunology, 2017 Innate immune cells are endowed with many nucleic acid receptors, but the role of sequence in the detection of foreign organisms remains unclear. Can sequence patterns influence recognition? In addition, how can we infer those patterns from sequence data?
Benjamin Greenbaum +2 more
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Analysis of Nucleotide Sequences Similarity and Protein Prediction of Some Resistance Genes in Escherichia coli Isolated from Iraqi Patients with Urinary Tract Infections [PDF]
Archives of Razi Institute, 2022 Antibiotic resistance leads to a dramatic increase in the morbidity and mortality caused by infectious diseases. Even though estimates vary widely, the economic cost of antimicrobial-resistant bacteria is on a rise.
R Kadhim Mohammed, A Attallah Ibrahim
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Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization
Pharmaceutics, 2020 In nature, genomes have been optimized by the evolution of their nucleic acid sequences. The design of peptide-like carriers as synthetic sequences provides a strategy for optimizing multifunctional targeted nucleic acid delivery in an iterative process.
Yanfang Wang, Ernst Wagner
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Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
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Aggregate, 2023 The ongoing outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) pandemic has posed significant challenges in early viral diagnosis. Hence, it is urgently desirable to develop a rapid, inexpensive, and sensitive method to aid point‐of‐
Qin Zhang +10 more
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Nucleic Acid Vaccines against SARS-CoV-2
Vaccines, 2022 The coronavirus disease 2019 (COVID-19) has spread worldwide and imposed a substantial burden on human health, the environment, and socioeconomic development, which has also accelerated the process of nucleic acid vaccine development and licensure ...
Ying Liu, Qing Ye
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Impact of Nucleic Acid Sequencing on Viroid Biology [PDF]
International Journal of Molecular Sciences, 2020 The early 1970s marked two breakthroughs in the field of biology: (i) The development of nucleotide sequencing technology; and, (ii) the discovery of the viroids. The first DNA sequences were obtained by two-dimensional chromatography which was later replaced by sequencing using electrophoresis technique.
Charith Raj Adkar-Purushothama +1 more
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Heliyon, 2023 The clustered regularly interspaced short palindromic DNA sequence repeats (CRISPR) and CRISPR-associated (Cas) (CRISPR/Cas) systems are currently applied not only as a gene editing tool but also as a novel molecular diagnostic technique.
Jian Zhou +4 more
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