Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure. [PDF]
Nucleic Acids Research, 1979 A dot hybridization method is presented for rapidly determining the relative concentrations of nucleic acids in a mixture, as well as the extent of sequence homology between related RNA or DNA species.
F. Kafatos, W. C. Jones, A. Efstratiadis
semanticscholar +2 more sources
Constrained Multistate Sequence Design for Nucleic Acid Reaction Pathway Engineering [PDF]
Journal of the American Chemical Society, 2017 We describe a framework for designing the sequences of multiple nucleic acid strands intended to hybridize in solution via a prescribed reaction pathway.
Dirks, Robert M. +4 more
core +4 more sources
Helicase processivity and not the unwinding velocity exhibits universal increase with force [PDF]
, 2015 Helicases, involved in a number of cellular functions, are motors that translocate along singlestranded nucleic acid and couple the motion to unwinding double-strands of a duplex nucleic acid. The junction between double and single strands creates a barrier to the movement of the helicase, which can be manipulated in vitro by applying mechanical forces
Chakrabarti, Shaon +2 more
arxiv +4 more sources
Human liver apolipoprotein B-100 cDNA: complete nucleic acid and derived amino acid sequence.
Proceedings of the National Academy of Sciences of the United States of America, 1986 Human apolipoprotein B-100 (apoB-100), the ligand on low density lipoproteins that interacts with the low density lipoprotein receptor and initiates receptor-mediated endocytosis and low density lipoprotein catabolism, has been cloned, and the complete ...
S. Law +6 more
semanticscholar +2 more sources
Secondary structure formation of homopolymeric single-stranded nucleic acids including force and loop entropy: implications for DNA hybridization [PDF]
arXiv, 2011 Loops are essential secondary structure elements in folded DNA and RNA molecules and proliferate close to the melting transition. Using a theory for nucleic acid secondary structures that accounts for the logarithmic entropy c ln m for a loop of length m, we study homopolymeric single-stranded nucleic acid chains under external force and varying ...
Einert, Thomas R. +2 more
arxiv +3 more sources
Nucleic Acid Sequence Design via Efficient Ensemble Defect Optimization [PDF]
Journal of Computational Chemistry, 2011 We describe an algorithm for designing the sequence of one or more interacting nucleic acid strands intended to adopt a target secondary structure at equilibrium.
Pierce, Niles A. +2 more
core +2 more sources
CFSP: a collaborative frequent sequence pattern discovery algorithm for nucleic acid sequence classification. [PDF]
PeerJ, 2020 Background Conserved nucleic acid sequences play an essential role in transcriptional regulation. The motifs/templates derived from nucleic acid sequence datasets are usually used as biomarkers to predict biochemical properties such as protein binding ...
Peng H.
europepmc +3 more sources
Rapid and Sensitive Isothermal Detection of Nucleic-acid Sequence by Multiple Cross Displacement Amplification. [PDF]
Sci Rep, 2015 We have devised a novel amplification strategy based on isothermal strand-displacement polymerization reaction, which was termed multiple cross displacement amplification (MCDA).
Wang Y +8 more
europepmc +2 more sources
Protein-Based Anchoring Methods for Nucleic Acid Detection in Lateral Flow Format Assays
Micromachines, 2023 The use of lateral flow assays to detect nucleic acid targets has many applications including point-of-care diagnostics, environmental monitoring, and food safety.
Kira Hallerbach +6 more
doaj +1 more source
Nucleic Acids Research, 2021 Sequence-based analysis and prediction are fundamental bioinformatic tasks that facilitate understanding of the sequence(-structure)-function paradigm for DNAs, RNAs and proteins.
Zhen Chen +11 more
semanticscholar +1 more source