Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors
Advanced Therapeutics, EarlyView.Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe +4 more
wiley +1 more source
SAM-dPCR: Real-Time and High-throughput Absolute Quantification of Biological Samples Using Zero-Shot Segment Anything Model [PDF]
arXivDigital PCR (dPCR) has revolutionized nucleic acid diagnostics by enabling absolute quantification of rare mutations and target sequences. However, current detection methodologies face challenges, as flow cytometers are costly and complex, while fluorescence imaging methods, relying on software or manual counting, are time-consuming and prone to errors.
arxiv
Diagnostic Value of Monitoring Human Cytomegalovirus Late pp67 mRNA Expression in Renal-Allograft Recipients by Nucleic Acid Sequence-Based Amplification [PDF]
, 1998 Marinus J. Blok +8 more
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Emerging Therapeutic Strategies for Hearing Loss
Advanced Therapeutics, EarlyView.Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han +9 more
wiley +1 more source
Platforms and Analytical Tools Used in Nucleic Acid Sequence-Based Microbial Genotyping Procedures. [PDF]
Microbiol Spectr, 2019 MacCannell D.
europepmc +1 more source
Computer methods to locate signals in nucleic acid sequences
, 1984 Rodger Staden
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Hydrophobin‐Coated Echogenic Microbubbles for Molecular Targeting of Tumor Cells
Advanced Science, EarlyView.Echogenic microbubbles based on hydrophobin and corresponding fusion protein (HFBI‐domZ) are developed as contrast agents for cancer diagnostics. Hydrophobin provides high stabilization of encapsulated perfluoro‐n‐butane, and fusion proteins allow further versatile functionalization with antibodies. In‐vitro experiments indicate that these microbubbles
Hedar H. Al‐Terke +8 more
wiley +1 more source
Development of a real-time nucleic acid sequence-based amplification assay for the rapid detection of Salmonella spp. from food. [PDF]
Braz J Microbiol, 2019 Zhai L +6 more
europepmc +1 more source
Simplified Identification of mRNA or DNA in Whole Cells [PDF]
A recently invented method of detecting a selected messenger ribonucleic acid (mRNA) or deoxyribonucleic acid (DNA) sequence offers two important advantages over prior such methods: it is simpler and can be implemented by means of compact equipment.
Almeida, Eduardo, Kadambi, Geeta
core +1 more source
A general procedure for locating and analyzing protein-binding sequence motifs in nucleic acids [PDF]
, 1998 Michael C. O’Neill
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