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Doublet frequencies in sequenced nucleic acids
Journal of Molecular Evolution, 1975A doublet frequency count (set of frequencies of the 16 possible two-base sequences) can be calculated from the experimentally determined overall sequence of a nucleic acid. In this paper, a statistical methodology is developed for comparing such counts with random, with others of the same type or with doublet proportions found in whole DNAs.
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Nucleic Acid Sequence Analysis Using DNAzymes
2004The sequence specificity of the "10-23" RNA-cleaving DNA enzyme can be utilized to discriminate between subtle differences in nucleic acid sequence. We examined this potential by comparing the cleavage activity of DNAzymes that target sequences derived from a relatively conserved segment of the L1 gene from different human papillomavirus (HPV ...
Murray J, Cairns, Lun-Quan, Sun
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Nucleic acids: Sequences and topology
Current Opinion in Structural Biology, 2002Abstract A selection of World Wide Web sites relevant to reviews published in this issue of Current Opinion in Structural Biology .
Murray-Rust J, Chalton DA, Craig PA
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Nucleic acid sequence analysis software packages
Current Opinion in Biotechnology, 1994Software packages have made sequence analysis easier and more accessible to research scientists in many fields. The majority of these packages are routinely upgraded to include improved and innovative programs for primer design, sequence assembly and improvements in database searching programs.
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Inferring consensus structure from nucleic acid sequences
Bioinformatics, 1991This paper presents an unsupervised inference method for determining the higher-order structure from sequence data. The method is general, but in this paper it is applied to nucleic acid sequences in determining the secondary (2-D) and tertiary (3-D) structure of the macromolecule.
D K, Chiu, T, Kolodziejczak
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Nucleic Acid Sequence Determination
1980It is often emphasised how closely the structure and function of biological materials are related to each other. This is certainly true for all biological macromolecules, but to some extent it is also true for any chemical substance: whether it takes part in a simple chemical reaction or in a complex biological process, the function of the molecule is ...
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Self-Assembling Sequence-Adaptive Peptide Nucleic Acids
Science, 2009Adaptable DNA Analogs The defining feature of DNA as a genetic blueprint is its capacity for self-replication. In the cell, however, the replication process requires the assistance of multiple elaborate enzymes. How then at the origin of life could DNA or its precursor replicate before enzymes were present?
Yasuyuki, Ura +4 more
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Introduction to Nucleic Acid Sequencing
2019Determining the order of nucleotide in the biological macromolecules has laid the foundation for understanding the biology of an organism. Over the last 50 years, genomics has been revolutionized with the researchers producing newer techniques and technologies leading to innovations in the field of DNA sequencing.
Preetha J. Shetty +2 more
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Nucleic Acids (DNA) Sequencing, Transcriptional
2006Transcriptional Sequencing (TS) is a novel DNA sequencing method based on the chain termination method using RNA Polymerase (RNAP). Transcriptional sequencing differs considerably from conventional cycle sequencing methods using DNA Polymerases (DNAPs) with 2′-deoxyribonucleotide triphosphates (2′-dNTPs) and 2′, 3′-dideoxyribonucleotide triphosphates ...
Kazuhiro Shibata +2 more
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