Results 271 to 280 of about 698,636 (336)

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Advanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu   +37 more
wiley   +1 more source

A Critical Review of the CRISPR-Cas Technology in the Detection of SARS-CoV-2 Variants. [PDF]

Can J Infect Dis Med Microbiol
Zhang J, Li J, Zhou J, Zhong J, Xu Y, Mao X, Xu M, Luo S, Yang Y, Hu R, Liu DA, Chen S, Qiu Y, Chen K, Yuan J, Zhang X, Li X.   +16 more
europepmc   +1 more source

Improved Detection of Rhinoviruses by Nucleic Acid Sequence-Based Amplification after Nucleotide Sequence Determination of the 5′ Noncoding Regions of Additional Rhinovirus Strains

, 2003
Katherine Loens, Margareta Ieven, D. Ursi, C. de Laat, Peter Sillekens, Peter Oudshoorn, Herman Goossens   +6 more
openalex   +1 more source

PTf‐SRiApt Targeting SCAF4‐POLR2A Interaction Suppresses Tumor Growth and Promotes Antitumor Immunity in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A phosphorothioate‐modified aptamer PTf‐SRiApt capable of disrupting “undruggable” transcription factor SCAF4‐POLR2A interaction with high inhibitory activity and biological stability is presented here. Through this inhibition, PTf‐SRiApt successfully arrested cell cycle progression, induced cell death, and elevated immune recruitment in SCAF4‐POLR2A ...
Liyan Fei, Yichun Pan, Jie Zhai, Tongqing Li, Yuxin Zhou, Sheyu Zhang, Juan Wei, Qian Hu, Xueying Liu, Lu Guo, Weizhu Wu, Yong Wei, Qin Wu, Weihong Tan   +13 more
wiley   +1 more source

Solid-state nanopore quantification of discrete sequence motifs from DNA and RNA targets in human plasma.

Analyst
Elaguech MA, Sethi K, Hall AR.
europepmc   +1 more source

Anti-RNA virus crRNA targets efficient screening platform based on bioinformatics and CRISPR detection. [PDF]

Mol Ther Nucleic Acids
Niu M, Dong Z, Yu L, Dong X, An J, Han Y, Yan Y, Yi W, Sun Y, Li H.   +9 more
europepmc   +1 more source

Bacteroides Fragilis‐Derived Outer Membrane Vesicles Deliver MiR‐5119 and Alleviate Colitis by Targeting PD‐L1 to Inhibit GSDMD‐Mediated Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Bacteroides fragilis‐derived outer membrane vesicles deliver miR‐5119 and alleviate colitis by targeting PD‐L1 to inhibit GSDMD‐mediated neutrophil extracellular trap formation. Abstract Inflammatory bowel disease (IBD) results from a breakdown in the symbiotic relationship between the intestinal commensal microflora and the mucosal immune system.
Yi Yang, Lanmengxi Yang, Yilin Yang, Haiyi Deng, Shiyu Su, Yinxiao Xia, Jin Su, Yuheng Liu, Junwei Wu, Jing Zhang, Yao Liao, Lifu Wang   +11 more
wiley   +1 more source

ASOptimizer: optimizing chemical diversity of antisense oligonucleotides through deep learning. [PDF]

Nucleic Acids Res
Kang S, Lee D, Hwang G, Lee K, Kang M.
europepmc   +1 more source

Gradient Solvent Replacement‐Mediated Formation of High‐Strength Hydrogel‐Forming Microneedle for Long‐Term Drug Delivery

Advanced Science, EarlyView.
A high‐strength pH‐responsive hydrogel‐forming microneedle integrates gradient solvent replacement to enhance the mechanical properties of the acrylonitrile‐acrylic acid copolymer network, ensuring robust transdermal penetration and long‐term drug release.
Hui Li, Fengzhen Meng, Chengwei Hu, Zhiyun Wu, Liuzhi Hao, Caijun Sun, Lijing Fang, Fan Pan, Shaoquan Bian, Huipeng Li, Mingjun Li, Bo Liu, Xiaoli Zhao   +12 more
wiley   +1 more source

Divergent B-cell repertoire remodelling by mRNA, DNA and live attenuated vaccines in fish. [PDF]

NPJ Vaccines
Porter D, Collins C, Mazzolini A, Jouneau L, Mhanna V, Coiffier C, Peruzzi M, Jaszczyszyn Y, Mariotti-Ferrandiz E, Huetz F, Collet B, Mora T, Walczak AM, Verrier B, Boudinot P.   +14 more
europepmc   +1 more source