Results 21 to 30 of about 775,236 (354)
Ab Initio Nucleic Acid Folding Simulations Using a Physics-Based Atomistic Free Energy Model [PDF]
, 2022 Performing full-resolution atomistic simulations of nucleic acid folding has remained a challenge for biomolecular modeling. Understanding how nucleic acids fold and how they transition between different folded structures as they unfold and refold has important implications for biology.
arxiv +1 more source
Nucleic Acid Probes in Microbiology [PDF]
, 2013 Single-stranded nucleic acid molecules can interact under certain conditions with other nucleic acids in the regions of base complementarily to form double-stranded hybrid molecules. From measurement of kinetics of the hybridisation and the extent of
Venkateswaran, K.S. +1 more
core +2 more sources
ESM-NBR: fast and accurate nucleic acid-binding residue prediction via protein language model feature representation and multi-task learning [PDF]
, 2023 Protein-nucleic acid interactions play a very important role in a variety of biological activities. Accurate identification of nucleic acid-binding residues is a critical step in understanding the interaction mechanisms. Although many computationally based methods have been developed to predict nucleic acid-binding residues, challenges remain.
arxiv +1 more source
Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core +1 more source
Aggregate, 2023 The ongoing outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) pandemic has posed significant challenges in early viral diagnosis. Hence, it is urgently desirable to develop a rapid, inexpensive, and sensitive method to aid point‐of‐
Qin Zhang +10 more
doaj +1 more source
Nucleic Acid Vaccines against SARS-CoV-2
Vaccines, 2022 The coronavirus disease 2019 (COVID-19) has spread worldwide and imposed a substantial burden on human health, the environment, and socioeconomic development, which has also accelerated the process of nucleic acid vaccine development and licensure ...
Ying Liu, Qing Ye
doaj +1 more source
Impact of Nucleic Acid Sequencing on Viroid Biology [PDF]
International Journal of Molecular Sciences, 2020 The early 1970s marked two breakthroughs in the field of biology: (i) The development of nucleotide sequencing technology; and, (ii) the discovery of the viroids. The first DNA sequences were obtained by two-dimensional chromatography which was later replaced by sequencing using electrophoresis technique.
Charith Raj Adkar-Purushothama +1 more
openaire +4 more sources
Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis
Aging and Cancer, Volume 3, Issue 3-4, Page 133-146, September-December 2022., 2022 One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...
Si‐Yuan Chen +3 more
wiley +1 more source
iTriplet, a rule-based nucleic acid sequence motif finder
Algorithms for Molecular Biology, 2009 Background With the advent of high throughput sequencing techniques, large amounts of sequencing data are readily available for analysis. Natural biological signals are intrinsically highly variable making their complete identification a computationally ...
Gunderson Samuel I +2 more
doaj +1 more source
United States Patent Application Publication: COUNTER SELECTION STRATEGY FOR GRAM-NEGATIVE BACTERIA [PDF]
, 2002 A Gram-negative bacterium useful for genetically engineering plants is provided. The Gram-negative bacterium contains, as part of genome, an inducible regulatory sequence operatively linked to a nucleotide sequence encoding a levansucrase. Alternatively,
Farrand, Stephen K. +2 more
core +2 more sources