Results 291 to 300 of about 1,249,290 (394)

CRISPR-Powered Liquid Biopsies in Cancer Diagnostics. [PDF]

Cells
Slattery JR, Naung NY, Kalinna BH, Pal M.   +3 more
europepmc   +1 more source

Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies

Advanced Science, EarlyView.
Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley   +1 more source

Methylene blue as a new signal tracer for nucleic acid-based lateral flow assay. [PDF]

Sci Rep
Noim JO, Kakadiya D, Dang S, Royez N, Ahuja S, Aryal KP, Tallur S, Pillai DR, Pandey R.   +8 more
europepmc   +1 more source

Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury

Advanced Science, EarlyView.
By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou, Fan Fan Hou, Haiyan Fu, Youhua Liu   +14 more
wiley   +1 more source

Establishment and application of a visual nucleic acid detection method for parvovirus. [PDF]

BMC Vet Res
Weng S, Zhang M, Zhu Y, Song Q, Zhang Y, Zhang S, Zhang K, Lin S, Ji X, Wang Y.   +9 more
europepmc   +1 more source

A Nucleic Acid Sequence–Based Amplification Method To Detect Salmonella enterica Serotype Enteritidis Strain PT4 in Liquid Whole Egg

, 2002
Nigel Cook, J. A. Ellison, Anna Kurdziel, S. A. Simpkins, John P. Hays   +4 more
openalex   +1 more source

m6A‐Modified circRAPGEF1 Interaction with IGF2BP3 Promotes Hepatocellular Carcinoma Progression via Reprogramming Aspartate Metabolism

Advanced Science, EarlyView.
In hepatocellular carcinoma (HCC), the m6A‐modified circRAPGEF1 destabilizes ASS1 mRNA via competitive binding to IGF2BP3, driving aspartate metabolic reprogramming in liver cancer stem cells (LCSCs). This cascade enhances stemness properties and reduces sorafenib sensitivity in LCSCs, thereby identifying circRAPGEF1 as a promising therapeutic target ...
Juanyi Shi, Sintim Mui, Yongcong Yan, Shaomin Liu, Kai Wen, Chuanchao He, Huoming Li, Hao Liao, Meng Tao, Jiahua Wen, Weidong Wang, Xiaoding Xu, Zhenyu Zhou, Zhiyu Xiao   +13 more
wiley   +1 more source

Predicting nucleic acid binding sites by attention map-guided graph convolutional network with protein language embeddings and physicochemical information. [PDF]

Brief Bioinform
Li X, Peng W, Zhu X.
europepmc   +1 more source

Nucleic acid sequence-based amplification methods to detect avian influenza virus

, 2003
Lok Ting Lau, J. Banks, Rebecca Aherne, Ian H. Brown, Natalie Dillon, Richard A. Collins, Ka-Yun Chan, Yin‐Wan Wendy Fung, Jun Xing, Albert Cheung Hoi Yu   +9 more
openalex   +1 more source

Integrated ‘Shield‐Spear’ Biological Patch for Fibrosis‐Free Bladder Reconstruction

Advanced Science, EarlyView.
Fibrosis‐free bladder reconstruction remains challenging. This study pioneers an integrated “shield‐spear” patch: The outer anionic hydrogel layer captures GATA6+ macrophages to suppress collagen overexpression, while the inner S100 aptamer‐engineered EVs target Schwann cells to downregulate the TGFβ/Smad pathway—inhibiting fibrosis with enhanced wound
Xiaoqi Wu, Huitong Ruan, Xiaolin Zhang, Weihan Zheng, Muhetaierjiang Mutailifu, Ling Wang, Liu Yu, Ruijun Peng, Rui Zhao, Zihan Wang, Jie Xu, Shaochuan Li, Yaobin Wu, Wenguo Cui, Mujun Lu   +14 more
wiley   +1 more source