Results 31 to 40 of about 1,295,417 (401)
Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core +1 more source
Aggregate, 2023 The ongoing outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) pandemic has posed significant challenges in early viral diagnosis. Hence, it is urgently desirable to develop a rapid, inexpensive, and sensitive method to aid point‐of‐
Qin Zhang +10 more
doaj +1 more source
ESM-NBR: fast and accurate nucleic acid-binding residue prediction via protein language model feature representation and multi-task learning [PDF]
, 2023 Protein-nucleic acid interactions play a very important role in a variety of biological activities. Accurate identification of nucleic acid-binding residues is a critical step in understanding the interaction mechanisms. Although many computationally based methods have been developed to predict nucleic acid-binding residues, challenges remain.
arxiv +1 more source
Identification of nucleic acid binding sites on translin-associated factor X (TRAX) protein. [PDF]
PLoS ONE, 2012 Translin and TRAX proteins play roles in very important cellular processes such as DNA recombination, spatial and temporal expression of mRNA, and in siRNA processing.
Gagan Deep Gupta, Vinay Kumar
doaj +1 more source
Nucleic Acid Probes in Microbiology [PDF]
, 2013 Single-stranded nucleic acid molecules can interact under certain conditions with other nucleic acids in the regions of base complementarily to form double-stranded hybrid molecules. From measurement of kinetics of the hybridisation and the extent of
Venkateswaran, K.S. +1 more
core +2 more sources
Mechanisms of HIV-1 Nucleocapsid Protein Inhibition by Lysyl-Peptidyl-Anthraquinone Conjugates [PDF]
, 2016 The Nucleocapsid protein NCp7 (NC) is a nucleic acid chaperone responsible for essential steps of the HIV-1 life cycle and an attractive candidate for drug development.
Alice Sosic +12 more
core +2 more sources
iTriplet, a rule-based nucleic acid sequence motif finder
Algorithms for Molecular Biology, 2009 Background With the advent of high throughput sequencing techniques, large amounts of sequencing data are readily available for analysis. Natural biological signals are intrinsically highly variable making their complete identification a computationally ...
Gunderson Samuel I +2 more
doaj +1 more source
Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers
Nature Chemistry, 2017 The evolution of sequence-defined synthetic polymers made of building blocks beyond those compatible with polymerase enzymes or the ribosome has the potential to generate new classes of receptors, catalysts and materials.
Zhen Chen +4 more
semanticscholar +1 more source
Nanomaterials, 2019 Several varieties of small nucleic acid constructs are able to modulate gene expression via one of a number of different pathways and mechanisms.
Paul Zakrevsky +5 more
doaj +1 more source
Mechanical properties of Nucleic Acids and the non-local Twistable Wormlike Chain model [PDF]
J. Chem. Phys. 156, 234105 (2022), 2022 Mechanical properties of nucleic acids play an important role in many biological processes which often involve physical deformations of these molecules. At sufficiently long length scales (say above $\sim 20-30$ base pairs) the mechanics of DNA and RNA double helices is described by a homogeneous Twistable Wormlike Chain (TWLC), a semiflexible polymer ...
arxiv +1 more source