Results 31 to 40 of about 775,236 (354)
Mechanical properties of Nucleic Acids and the non-local Twistable Wormlike Chain model [PDF]
J. Chem. Phys. 156, 234105 (2022), 2022 Mechanical properties of nucleic acids play an important role in many biological processes which often involve physical deformations of these molecules. At sufficiently long length scales (say above $\sim 20-30$ base pairs) the mechanics of DNA and RNA double helices is described by a homogeneous Twistable Wormlike Chain (TWLC), a semiflexible polymer ...
arxiv +1 more source
Nanomaterials, 2019 Several varieties of small nucleic acid constructs are able to modulate gene expression via one of a number of different pathways and mechanisms.
Paul Zakrevsky +5 more
doaj +1 more source
Pairwise alignment of the DNA sequence using hypercomplex number representation [PDF]
Bulletin of Mathematical Biology, Vol. 66, No. 5, pp. 1423-1438,
2004, 2014 A new set of DNA base-nucleic acid codes and their hypercomplex number representation have been introduced for taking the probability of each nucleotide into full account. A new scoring system has been proposed to suit the hypercomplex number representation of the DNA base-nucleic acid codes and incorporated with the method of dot matrix analysis and ...
arxiv +1 more source
Applied Microscopy, 2019 Fluorescence imaging of nucleic acids is a very important technique necessary to understand gene expression and the resulting changes in cell function. This mini-review focuses on sequence-specific fluorescence imaging of intracellular RNA and methylated
Akimitsu Okamoto
doaj +1 more source
Simultaneous control of DNA and RNA processing efficiency using a nucleic acid calibration set. [PDF]
, 2007 PCR-based detection techniques enables reliable and sensitive nucleic acid target detection. However, quantitative determination methods often fail to control for the efficiency of nucleic acid extraction, reverse transcription, and PCR amplification ...
Anna Rosa Garbuglia +5 more
core +1 more source
Improving the specificity of nucleic acid detection with endonuclease-actuated degradation
Communications Biology, 2022 A new method, SENTINEL, improves the specificity of nucleic acid target sequence identification via a combination of isothermal amplification and sequence-specific DNA endonucleases. The method can discriminate single base-pair differences and takes less
Roger S. Zou +11 more
doaj +1 more source
A Global Nucleic Acid Observatory for Biodefense and Planetary Health [PDF]
arXiv, 2021 The spread of pandemic viruses and invasive species can be catastrophic for human societies and natural ecosystems. SARS-CoV-2 demonstrated that the speed of our response is critical, as each day of delay permitted exponential growth and dispersion of the virus.
arxiv
Nucleic Acid Probes for Single-Molecule Localization Imaging of Cellular Biomolecules
Chemical & Biomedical Imaging, 2023 Endogenous biomolecules in cells are the basis of all life activities. Directly visualizing the structural characteristics and dynamic behaviors of cellular biomolecules is significant for understanding the molecular mechanisms in various biological ...
Junyuan Wei +5 more
doaj +1 more source
BioTechniques, 2000 The size of sequence databases, the rapid rate of generating sequence data and the need to routinely construct recombinant DNA molecules in molecular biological research necessitate the frequent handling and analysis of nucleotide and protein sequences ...
Hugh G. Patterton, Steven Graves
doaj +1 more source
BioTechniques, 2018 Digital PCR has been promoted as a technique for obtaining absolute measures of the amount of nucleic acid target sequence in a sample, but still lacks standardization in data reporting.
Sherry J Coulter
doaj +1 more source