Results 31 to 40 of about 1,249,290 (394)

A Suite of Therapeutically-Inspired Nucleic Acid Logic Systems for Conditional Generation of Single-Stranded and Double-Stranded Oligonucleotides

Nanomaterials, 2019
Several varieties of small nucleic acid constructs are able to modulate gene expression via one of a number of different pathways and mechanisms.
Paul Zakrevsky, Eckart Bindewald, Hadley Humbertson, Mathias Viard, Nomongo Dorjsuren, Bruce A. Shapiro   +5 more
doaj   +1 more source

tmRNA - a novel high-copy-number RNA diagnostic target - its application for Staphylococcus aureus detection using real-time NASBA [PDF]

, 2009
A real-time nucleic acid sequence-based amplification assay, targeting tmRNA, was designed for the rapid identification of Staphylococcus aureus. The selectivity of the assay was confirmed against a panel of 76 Staphylococcus strains and species and 22 ...
Anonymous, Anonymous, Anonymous, Anonymous, Barry Glynn, Justin O'Grady, Katrina Lacey, Majella Maher, Terry J. Smith, Thomas Barry   +9 more
core   +1 more source

Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers

Nature Chemistry, 2017
The evolution of sequence-defined synthetic polymers made of building blocks beyond those compatible with polymerase enzymes or the ribosome has the potential to generate new classes of receptors, catalysts and materials.
Zhen Chen, Phillip A. Lichtor, Adrian P. Berliner, Jonathan C. Chen, David R. Liu   +4 more
semanticscholar   +1 more source

iTriplet, a rule-based nucleic acid sequence motif finder

Algorithms for Molecular Biology, 2009
Background With the advent of high throughput sequencing techniques, large amounts of sequencing data are readily available for analysis. Natural biological signals are intrinsically highly variable making their complete identification a computationally ...
Gunderson Samuel I, Jakubowski Christopher D, Ho Eric S   +2 more
doaj   +1 more source

A CRISPR-based nucleic acid detection method for severe fever with thrombocytopenia syndrome virus

Virus Research, 2022
Objective: Fever with thrombocytopenia syndrome virus (SFTS) is a tick-borne infection now known to spread among humans as an aerosol, which has resulted in several outbreaks across Asia over the past decade.
Yansong Zhang, Xuanyang Bai, Jinhui Li, Jing Xie, Huan Li, Lang Yang, Peihan Li, Peng Li, Hao Dong, Qichao Chen, Xinyan Hu, Yun Wang, Tingting Jiang, Hongbin Song, Leili Jia, Lizhong Li   +15 more
doaj   +1 more source

Insights into DNA platination within unusual structural settings [PDF]

, 2011
2D [1H, 15N] HSQC NMR spectroscopy has been used to monitor reaction and product formation between [Pt(15NH3)2I2] and nucleic acids possessing irregular topologies and containing site specific phosphorothioate substitution in the phosphodiester backbone.
Harvie, Stephanie, Parkinson, John A, Wilson, Owen   +2 more
core   +2 more sources

Next-generation fluorescent nucleic acids probes for microscopic analysis of intracellular nucleic acids

Applied Microscopy, 2019
Fluorescence imaging of nucleic acids is a very important technique necessary to understand gene expression and the resulting changes in cell function. This mini-review focuses on sequence-specific fluorescence imaging of intracellular RNA and methylated
Akimitsu Okamoto
doaj   +1 more source

Improving the specificity of nucleic acid detection with endonuclease-actuated degradation

Communications Biology, 2022
A new method, SENTINEL, improves the specificity of nucleic acid target sequence identification via a combination of isothermal amplification and sequence-specific DNA endonucleases. The method can discriminate single base-pair differences and takes less
Roger S. Zou, Momcilo Gavrilov, Yang Liu, Dominique Rasoloson, Madison Conte, Justin Hardick, Leo Shen, Siqi Chen, Andrew Pekosz, Geraldine Seydoux, Yukari C. Manabe, Taekjip Ha   +11 more
doaj   +1 more source

Monolithic centrifugal microfluidic platform for bacteria capture and concentration, lysis, nucleic-acid amplification, and real-time detection [PDF]

, 2009
We report the design, fabrication, and characterization of a polymer centrifugal microfluidic system for the specific detection of bacterial pathogens.
Barry, Thomas, Dimov, Ivan Krastev, Ducrée, Jens, Garcia-Cordero, Jose L., O'Grady, J., Ricco, Antonio J.   +5 more
core   +1 more source

Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides

Nucleic Acids Research, 2014
Fully phosphorothioate antisense oligonucleotides (ASOs) with locked nucleic acids (LNAs) improve target affinity, RNase H activation and stability. LNA modified ASOs can cause hepatotoxicity, and this risk is currently not fully understood.
Andrew D. Burdick, Simone Sciabola, Srinivasa R. Mantena, B. Hollingshead, R. Stanton, J. Warneke, Mingyue Zeng, E. Martsen, A. Medvedev, S. Makarov, Lori A Reed, J. W. Davis, L. Whiteley   +12 more
semanticscholar   +1 more source