Nucleic acid drugs: a novel approach [PDF]
, 2005 Nucleic acid base sequence of proteins plays a crucial role in the expression of gene. The gene is responsible for the synthesis of proteins and these proteins, which are synthesized, are responsible for the biological process and also for dreadful ...
Dubey, Pawan +4 more
core +2 more sources
Application of CRISPR/Cas Systems in the Nucleic Acid Detection of Infectious Diseases
Diagnostics, 2022 The CRISPR/Cas system is a protective adaptive immune system against attacks from foreign mobile genetic elements. Since the discovery of the excellent target-specific sequence recognition ability of the CRISPR/Cas system, the CRISPR/Cas system has shown
Junwei Li +8 more
doaj +1 more source
Sneak peek at the tig sequences: useful sequences built from nucleic acid data [PDF]
arXiv, 2022 This manuscript is a tutorial on tig sequences that emerged after the name "contig", and are of diverse purposes in sequence bioinformatics. We review these different sequences (unitigs, simplitigs, monotigs, omnitigs to cite a few), give intuitions of their construction and interest, and provide some examples of applications.
arxiv
Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases
Frontiers in Genetics, 2014 The universal 3'-terminal CCA sequence of tRNA is built and/or synthesized by the CCA-adding enzyme, CTP:(ATP) tRNA nucleotidyltransferase. This RNA polymerase has no nucleic acid template, but faithfully synthesizes the defined CCA sequence on the 3 ...
Kozo eTomita, Seisueke eYamashita
doaj +1 more source
Comparison of the RNA-amplification based methods RT–PCR and NASBA for the detection of circulating tumour cells [PDF]
, 2002 Increasingly, reverse transcriptase polymerase chain reaction (RT–PCR) is used to detect clinically significant tumour cells in blood or bone marrow. This may result in a redefinition of disease-free and clinical relapse.
Burchill, S A +4 more
core +2 more sources
First-principles Study of Physisorption of Nucleic Acid Bases on Small-Diameter Carbon Nanotube [PDF]
Nanotechnology 19, 125701 (2008), 2007 We report the results of our first-principles study based on density functional theory on the interaction of the nucleic acid base molecules adenine (A), cytosine (C), guanine (G), thymine (T), and uracil (U), with a single-walled carbon nanotube (CNT).
arxiv +1 more source
Useful Microsoft® WordTM Macros for Molecular Biologists and Protein Chemists
BioTechniques, 2000 Biologists today make extensive use of word processing programs for the production of research reports, literature reviews and grant proposals. Frequently, such programs become the default platform for viewing and the later publication of protein and ...
Gerry Shaw
doaj +1 more source
Mth10b, a unique member of the Sac10b family, does not bind nucleic acid. [PDF]
PLoS ONE, 2011 The Sac10b protein family is regarded as a group of nucleic acid-binding proteins that are highly conserved and widely distributed within archaea. All reported members of this family are basic proteins that exist as homodimers in solution and bind to DNA
Yan-Feng Liu +5 more
doaj +1 more source
Sequence Multiplicity within Spherical Nucleic Acids [PDF]
ACS Nano, 2020 The synthesis and evaluation of spherical nucleic acids (SNAs) incorporating two physically and chemically distinct classes of oligonucleotides (ODNs) at programmed ratios are described. These SNAs are single entity agents that enter the same target cell at defined stoichiometries, and as such allow one to control important cell signaling and ...
Chad A. Mirkin +8 more
openaire +3 more sources
Mechanisms of HIV-1 Nucleocapsid Protein Inhibition by Lysyl-Peptidyl-Anthraquinone Conjugates [PDF]
, 2016 The Nucleocapsid protein NCp7 (NC) is a nucleic acid chaperone responsible for essential steps of the HIV-1 life cycle and an attractive candidate for drug development.
Alice Sosic +12 more
core +2 more sources