Results 41 to 50 of about 1,249,290 (394)

Nucleic and Amino Acid Sequences Support Structure-Based Viral Classification [PDF]

, 2017
Viral capsids ensure viral genome integrity by protecting the enclosed nucleic acids. Interactions between the genome and capsid and between individual capsid proteins (i.e., capsid architecture) are intimate and are expected to be characterized by ...
Bamford, Dennis H., Ravantti, Janne J., Sinclair, Robert M.   +2 more
core   +2 more sources

Highly specific enrichment of rare nucleic acid fractions using Thermus thermophilus argonaute with applications in cancer diagnostics

Nucleic Acids Research, 2019
Detection of disease-associated, cell-free nucleic acids in body fluids enables early diagnostics, genotyping and personalized therapy, but is challenged by the low concentrations of clinically significant nucleic acids and their sequence homology with ...
Jinzhao Song, Jorrit W. Hegge, M. Mauk, Junman Chen, Jacob E. Till, Neha Bhagwat, Lotte T. Azink, Jing Peng, Moen Sen, Jazmine Mays, E. Carpenter, John van der Oost, H. Bau   +12 more
semanticscholar   +1 more source

DNAssist, a C++ Program for Editing and Analysis of Nucleic Acid and Protein Sequences on PC-Compatible Computers Running Windows 95, 98, NT4.0 or 2000

BioTechniques, 2000
The size of sequence databases, the rapid rate of generating sequence data and the need to routinely construct recombinant DNA molecules in molecular biological research necessitate the frequent handling and analysis of nucleotide and protein sequences ...
Hugh G. Patterton, Steven Graves
doaj   +1 more source

Nucleic Acid Probes for Single-Molecule Localization Imaging of Cellular Biomolecules

Chemical & Biomedical Imaging, 2023
Endogenous biomolecules in cells are the basis of all life activities. Directly visualizing the structural characteristics and dynamic behaviors of cellular biomolecules is significant for understanding the molecular mechanisms in various biological ...
Junyuan Wei, Cailing Ji, Yingfei Wang, Jie Tan, Quan Yuan, Weihong Tan   +5 more
doaj   +1 more source

Mitigation of the effect of variability in digital PCR assays through use of duplexed reference assays for normalization

BioTechniques, 2018
Digital PCR has been promoted as a technique for obtaining absolute measures of the amount of nucleic acid target sequence in a sample, but still lacks standardization in data reporting.
Sherry J Coulter
doaj   +1 more source

Robustness and modularity properties of a non-covalent DNA catalytic reaction [PDF]

, 2009
The biophysics of nucleic acid hybridization and strand displacement have been used for the rational design of a number of nanoscale structures and functions. Recently, molecular amplification methods have been developed in the form of non-covalent DNA
Aldaye, Clo, D. Y. Zhang, E. Winfree, Feldkamp, Flamm, Frezza, Gao, Lubrich, Marras, Puglisi, SantaLucia, Seelig, Seelig, Turberfield, Yin, Yurke, Zhang, Zhang, Zhang, Zuker   +20 more
core   +4 more sources

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology.

ACS Nano, 2019
Nucleic acids play a central role in all domains of life, either as genetic blueprints or as regulators of various biochemical pathways. The chemical makeup of ribonucleic (RNA) or deoxyribonucleic (DNA) acids, generally represented by a sequence of four
Martin Panigaj, Martin Panigaj, M. B. Johnson, Weina Ke, Jessica McMillan, E. A. Goncharova, Morgan R Chandler, K. Afonin   +7 more
semanticscholar   +1 more source

Nucleic Acid Sequence-Based Amplification using molecular beacons for quantification of enterovirus RNA

Microbiologia Medica, 2011
Quantificazione dell’enterovirus RNA mediante Nucleic Acid Sequence-Based Amplification utilizzando sonde molecular ...
Francesca Sidoti, Massimiliano Bergallo, Maria Elena Terlizzi, Sara Astegiano, Cristina Costa, Rossana Cavallo   +5 more
doaj   +1 more source

Application of CRISPR/Cas Systems in the Nucleic Acid Detection of Infectious Diseases

Diagnostics, 2022
The CRISPR/Cas system is a protective adaptive immune system against attacks from foreign mobile genetic elements. Since the discovery of the excellent target-specific sequence recognition ability of the CRISPR/Cas system, the CRISPR/Cas system has shown
Junwei Li, Yuexia Wang, Bin Wang, Juan Lou, Peng Ni, Yuefei Jin, Shuaiyin Chen, Guangcai Duan, Rongguang Zhang   +8 more
doaj   +1 more source

Slow nucleic acid unzipping kinetics from sequence-defined barriers

, 2002
Recent experiments on unzipping of RNA helix-loop structures by force have shown that about 40-base molecules can undergo kinetic transitions between two well-defined `open' and `closed' states, on a timescale = 1 sec [Liphardt et al., Science 297, 733 ...
Cocco, S., Marko, J. F., Monasson, R.
core   +1 more source