Results 41 to 50 of about 1,295,417 (401)
The polymerase chain reaction [PDF]
, 2003 The Polymerase Chain Reaction (PCR) is a technique for the in vitro synthesis of billions of copies of a specific nucleic acid sequence by performing successive rounds of in vitro nucleic acid replication.
Paulton, M P, Thomas, P C
core +1 more source
Applied Microscopy, 2019 Fluorescence imaging of nucleic acids is a very important technique necessary to understand gene expression and the resulting changes in cell function. This mini-review focuses on sequence-specific fluorescence imaging of intracellular RNA and methylated
Akimitsu Okamoto
doaj +1 more source
Pairwise alignment of the DNA sequence using hypercomplex number representation [PDF]
Bulletin of Mathematical Biology, Vol. 66, No. 5, pp. 1423-1438,
2004, 2014 A new set of DNA base-nucleic acid codes and their hypercomplex number representation have been introduced for taking the probability of each nucleotide into full account. A new scoring system has been proposed to suit the hypercomplex number representation of the DNA base-nucleic acid codes and incorporated with the method of dot matrix analysis and ...
arxiv +1 more source
ENA as an Information Hub [PDF]
, 2010 The European Nucleotide Archive (ENA; "http://www.ebi.ac.uk/ena/":http://www.ebi.ac.uk/ena/) is a comprehensive repository for public nucleotide sequence data from nearly four hundred thousand taxonomic nodes.
Bob Vaughan +5 more
core +2 more sources
A Global Nucleic Acid Observatory for Biodefense and Planetary Health [PDF]
arXiv, 2021 The spread of pandemic viruses and invasive species can be catastrophic for human societies and natural ecosystems. SARS-CoV-2 demonstrated that the speed of our response is critical, as each day of delay permitted exponential growth and dispersion of the virus.
arxiv
Furan-PNA : a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA [PDF]
, 2016 We here report on the design and synthesis of tailor-made furan-modified peptide nucleic acid (PNA) probes for covalent targeting of single stranded DNA through a crosslinking strategy.
Corradini, Roberto +3 more
core +2 more sources
Nucleic Acids Research, 2014 Fully phosphorothioate antisense oligonucleotides (ASOs) with locked nucleic acids (LNAs) improve target affinity, RNase H activation and stability. LNA modified ASOs can cause hepatotoxicity, and this risk is currently not fully understood.
Andrew D. Burdick +12 more
semanticscholar +1 more source
Improving the specificity of nucleic acid detection with endonuclease-actuated degradation
Communications Biology, 2022 A new method, SENTINEL, improves the specificity of nucleic acid target sequence identification via a combination of isothermal amplification and sequence-specific DNA endonucleases. The method can discriminate single base-pair differences and takes less
Roger S. Zou +11 more
doaj +1 more source
The Jena Library of Biological Macromolecules - JenaLib [PDF]
, 2009 The JenaLib database ("www.fli-leibniz.de/IMAGE.html":http://www.fli-leibniz.de/IMAGE.html) offers value-added information for all Protein Data Bank (PDB) and Nucleic Acid Database (NDB) entries.
Juergen Suehnel, Rolf Huehne
core +2 more sources
Nucleic Acids Research, 2019 Detection of disease-associated, cell-free nucleic acids in body fluids enables early diagnostics, genotyping and personalized therapy, but is challenged by the low concentrations of clinically significant nucleic acids and their sequence homology with ...
Jinzhao Song +12 more
semanticscholar +1 more source