Results 51 to 60 of about 1,295,417 (401)

Nucleic Acid Probes for Single-Molecule Localization Imaging of Cellular Biomolecules

open access: yesChemical & Biomedical Imaging, 2023
Endogenous biomolecules in cells are the basis of all life activities. Directly visualizing the structural characteristics and dynamic behaviors of cellular biomolecules is significant for understanding the molecular mechanisms in various biological ...
Junyuan Wei   +5 more
doaj   +1 more source

DNAssist, a C++ Program for Editing and Analysis of Nucleic Acid and Protein Sequences on PC-Compatible Computers Running Windows 95, 98, NT4.0 or 2000

open access: yesBioTechniques, 2000
The size of sequence databases, the rapid rate of generating sequence data and the need to routinely construct recombinant DNA molecules in molecular biological research necessitate the frequent handling and analysis of nucleotide and protein sequences ...
Hugh G. Patterton, Steven Graves
doaj   +1 more source

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology.

open access: yesACS Nano, 2019
Nucleic acids play a central role in all domains of life, either as genetic blueprints or as regulators of various biochemical pathways. The chemical makeup of ribonucleic (RNA) or deoxyribonucleic (DNA) acids, generally represented by a sequence of four
Martin Panigaj   +7 more
semanticscholar   +1 more source

Mitigation of the effect of variability in digital PCR assays through use of duplexed reference assays for normalization

open access: yesBioTechniques, 2018
Digital PCR has been promoted as a technique for obtaining absolute measures of the amount of nucleic acid target sequence in a sample, but still lacks standardization in data reporting.
Sherry J Coulter
doaj   +1 more source

CRISPR-induced DNA reorganization for multiplexed nucleic acid detection

open access: yesNature Communications, 2023
Nucleic acid sensing involving CRISPR technologies is powerful but has certain limitations, such as PAM sequence requirements and limited multiplexing.
Margot Karlikow   +15 more
doaj   +1 more source

tmRNA - a novel high-copy-number RNA diagnostic target - its application for Staphylococcus aureus detection using real-time NASBA [PDF]

open access: yes, 2009
A real-time nucleic acid sequence-based amplification assay, targeting tmRNA, was designed for the rapid identification of Staphylococcus aureus. The selectivity of the assay was confirmed against a panel of 76 Staphylococcus strains and species and 22 ...
Anonymous   +9 more
core   +1 more source

Nucleic Acid Sequence-Based Amplification using molecular beacons for quantification of enterovirus RNA

open access: yesMicrobiologia Medica, 2011
Quantificazione dell’enterovirus RNA mediante Nucleic Acid Sequence-Based Amplification utilizzando sonde molecular ...
Francesca Sidoti   +5 more
doaj   +1 more source

Slow nucleic acid unzipping kinetics from sequence-defined barriers

open access: yes, 2002
Recent experiments on unzipping of RNA helix-loop structures by force have shown that about 40-base molecules can undergo kinetic transitions between two well-defined `open' and `closed' states, on a timescale = 1 sec [Liphardt et al., Science 297, 733 ...
Cocco, S., Marko, J. F., Monasson, R.
core   +1 more source

Logic devices based on nucleic acid self‐assembly

open access: yesInfoMat, 2021
Nucleic acids are natural macromolecules with the ability to store and transmit information based on the strict base‐pairing principle. Beyond the natural nucleic acid double helixes, various DNA/RNA nanostructures with customized geometries and ...
Xuehui Xu   +4 more
doaj   +1 more source

Application of CRISPR/Cas Systems in the Nucleic Acid Detection of Infectious Diseases

open access: yesDiagnostics, 2022
The CRISPR/Cas system is a protective adaptive immune system against attacks from foreign mobile genetic elements. Since the discovery of the excellent target-specific sequence recognition ability of the CRISPR/Cas system, the CRISPR/Cas system has shown
Junwei Li   +8 more
doaj   +1 more source

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