Results 51 to 60 of about 775,236 (354)

Logic devices based on nucleic acid self‐assembly

InfoMat, 2021
Nucleic acids are natural macromolecules with the ability to store and transmit information based on the strict base‐pairing principle. Beyond the natural nucleic acid double helixes, various DNA/RNA nanostructures with customized geometries and ...
Xuehui Xu, Yingxu Shang, Fengsong Liu, Qiao Jiang, Baoquan Ding   +4 more
doaj   +1 more source

Slow nucleic acid unzipping kinetics from sequence-defined barriers

, 2002
Recent experiments on unzipping of RNA helix-loop structures by force have shown that about 40-base molecules can undergo kinetic transitions between two well-defined `open' and `closed' states, on a timescale = 1 sec [Liphardt et al., Science 297, 733 ...
Cocco, S., Marko, J. F., Monasson, R.
core   +1 more source

Nucleic Acid-based Diagnosis and Epidemiology of Infectious Diseases [PDF]

, 2016
In this chapter, the immense contribution of nucleic acid discovery to the diagnosis and molecular epidemiology of pathogenic microorganisms and its relevance for veterinary and human health will be discussed.
Aparecida Sperança, Márcia, Buzinaro Suzuki, Rodrigo, Diniz Cabral, Aline, Moreira dos Santos Carmo, Andreia   +3 more
core   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

FEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

A method to find palindromes in nucleic acid sequences [PDF]

Bioinformation, 2013
Various types of sequences in the human genome are known to play important roles in different aspects of genomic functioning. Among these sequences, palindromic nucleic acid sequences are one such type that have been studied in detail and found to influence a wide variety of genomic characteristics.
Mani Shankar, Kanagaraj Sekar, Ramnath Anjana, Marthandan Kirti Vaishnavi   +3 more
openaire   +2 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Sensing of nucleic acid sequences using unmodifiednucleic acid as a probe [PDF]

Nucleic Acids Symposium Series, 2007
We present a strategy to generate a light-up fluorophore-aptamer pair. The strategy was based on a modification of a conventional DNA-staining dye to suppress its affinity to the original targets, and subsequent re-selection of aptamers that would bind to the modified dye.
Atsushi Narita, Yasuhiro Aoyama, Shinsuke Sando   +2 more
openaire   +3 more sources

Method Utilizing the Tobacco Phylloplanin Promoter for Expression of Nucleic Acids as Gene Products Directed to Aerial Surfaces of Plants [PDF]

, 2009
A method and system is provided for generating excreted gene products in a plant which includes generating a nucleic acid fusion construct comprising a phylloplanin promoter and a selected non-phylloplanin nucleic acid sequence whose transcription ...
Shepard, Ryan W., Wagner, George J.
core   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

SOFB is a comprehensive ensemble deep learning approach for elucidating and characterizing protein-nucleic-acid-binding residues

Communications Biology
Proteins and nucleic-acids are essential components of living organisms that interact in critical cellular processes. Accurate prediction of nucleic acid-binding residues in proteins can contribute to a better understanding of protein function.
Bin Zhang, Zilong Hou, Yuning Yang, Ka-chun Wong, Haoran Zhu, Xiangtao Li   +5 more
doaj   +1 more source