Results 81 to 90 of about 1,295,417 (401)

ACNUC - a portable retrieval system for nucleic acid sequence databases: logical and physical designs and usage

Comput. Appl. Biosci., 1985
ACNUC is a database structure and retrieval software for use with either the GenBank or EMBL nucleic acid sequence data collections. The nucleotide and textual data furnished by both collections are each restructured into a database that allows sequence ...
M. Gouy, C. Gautier, M. Attimonelli, C. Lanave, G. Paola   +4 more
semanticscholar   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Machine Learning Guides Peptide Nucleic Acid Flow Synthesis and Sequence Design

Advanced Science, 2022
Peptide nucleic acids (PNAs) are potential antisense therapies for genetic, acquired, and viral diseases. Efficiently selecting candidate PNA sequences for synthesis and evaluation from a genome containing hundreds to thousands of options can be ...
Chengxi Li, Genwei Zhang, Somesh Mohapatra, Alex J. Callahan, Andrei Loas, Rafael Gómez‐Bombarelli, Bradley L. Pentelute   +6 more
doaj   +1 more source

Molecular Dynamics Analysis of Biomolecular Systems Including Nucleic Acids [PDF]

arXiv, 2021
Along with recent progress in structural biology and genome biology, structural dynamics of molecular systems including nucleic acids has attracted attention in the context of gene regulation. Structure-function relationship is an important topic, where physicochemical properties of nucleotides are important as well as those of amino acids in proteins.
arxiv  

United States Patent Application Publication: COUNTER SELECTION STRATEGY FOR GRAM-NEGATIVE BACTERIA [PDF]

, 2002
A Gram-negative bacterium useful for genetically engineering plants is provided. The Gram-negative bacterium contains, as part of genome, an inducible regulatory sequence operatively linked to a nucleotide sequence encoding a levansucrase. Alternatively,
Farrand, Stephen K., Staswick, Paul E., Clemente, Thomas E.   +2 more
core   +2 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Method for detecting Ralstonia solanacearum race 3 biovar 2 [PDF]

, 2009
The invention concerns a method for the detection of Ralstonia solanacearum race 3 biovar 2 strains in a medium, comprising the determination of the presence or the absence in a sample of the medium, of: (i) at least one first nucleic acid target having ...
Boucher, Christian, Elbaz, Mounira, Genin, Stéphane, Guidot, Alice, Prior, Philippe   +4 more
core  

Simultaneous control of DNA and RNA processing efficiency using a nucleic acid calibration set. [PDF]

, 2007
PCR-based detection techniques enables reliable and sensitive nucleic acid target detection. However, quantitative determination methods often fail to control for the efficiency of nucleic acid extraction, reverse transcription, and PCR amplification ...
Anna Rosa Garbuglia, Barbara Bartolini, Douglas Horejsh, Fabrizio Carletti, Federico Martini, Maria Rosaria Capobianchi   +5 more
core   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Nucleic Acid Ligands Based on Carbohydrates

CHIMIA, 1996
Sequence-specific nucleic acid ligands are important tools in chemistry and molecular biology and are thought to possess a considerable pharmaceutical potential. An overview of the structurally and mechanistically diverse approaches in the field
Jürg Hunziker
doaj   +2 more sources