Results 51 to 60 of about 1,128,851 (326)
Causal Discovery for Gene Regulatory Network Prediction [PDF]
arXiv, 2023 Biological systems and processes are networks of complex nonlinear regulatory interactions between nucleic acids, proteins, and metabolites. A natural way in which to represent these interaction networks is through the use of a graph. In this formulation, each node represents a nucleic acid, protein, or metabolite and edges represent intermolecular ...
arxiv
Dioxaphosphorinane-Constrained Nucleic Acid Dinucleotides as Tools for Structural Tuning of Nucleic Acids [PDF]
Journal of Nucleic Acids, 2012 We describe a rational approach devoted to modulate the sugar-phosphate backbone geometry of nucleic acids. Constraints were generated by connecting one oxygen of the phosphate group to a carbon of the sugar moiety. The so-called dioxaphosphorinane rings were introduced at key positions along the sugar-phosphate backbone allowing the control of the six-
Catana, Dan-Andrei +5 more
openaire +5 more sources
Nucleic Acid Structure Characterization by Small Angle X‐Ray Scattering (SAXS)
Current Protocols in Nucleic Acid Chemistry, 2012 Small angle X‐ray scattering (SAXS) is a powerful method for investigating macromolecular structure in solution. SAXS data provide information about the size and shape of a molecule with a resolution of ∼2 to 3 nm.
J. Burke, S. Butcher
semanticscholar +1 more source
Sharing and archiving nucleic acid structure mapping data.
RNA: A publication of the RNA Society, 2011 Nucleic acids are particularly amenable to structural characterization using chemical and enzymatic probes. Each individual structure mapping experiment reveals specific information about the structure and/or dynamics of the nucleic acid.
P. Rocca-Serra +16 more
semanticscholar +1 more source
Indonesian Journal of Chemistry, 2022 Mitochondrial DNA mutations, such as A3243G, can affect changes in the structure of biomolecules, resulting in changes in the structure of Leucine transfer Ribose Nucleic Acid to form a dimer.
Iman Permana Maksum +5 more
doaj +1 more source
Halogen Bonding in Nucleic Acid Complexes [PDF]
, 2017 Halogen bonding (X-bonding) has attracted notable attention among noncovalent interactions. This highly directional attraction between a halogen atom and an electron donor has been exploited in knowledge-based drug design. A great deal of information has been gathered about X-bonds in protein-ligand complexes, as opposed to nucleic acid complexes. Here
arxiv +1 more source
FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source
Tobacco Mosaic Virus Movement: From Capsid Disassembly to Transport Through Plasmodesmata
VirusesDetermining mechanisms to establish an initial infection and form intracellular complexes for accumulation and movement of RNA plant viruses are important areas of study in plant virology.
Amr Ibrahim +3 more
doaj +1 more source
Photochemistry and structure in nucleic acids [PDF]
Pure and Applied Chemistry, 1973 Abstract
openaire +3 more sources
Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors
Molecular Oncology, EarlyView.Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi +6 more
wiley +1 more source