Results 101 to 110 of about 34,544 (276)
Biocompatible Chemistry: A Plug‐and‐Play Toolbox for Chemical Biology Research
ChemBioChem, EarlyView.The “plug‐and‐play” nature of biocompatible chemistry makes it a powerful toolbox for investigating complicated biological systems and producing drug leads for clinical usages. This review summarizes the commonly used biocompatible reactions and the recent advances of their representative applications in chemical biology research, thus highlighting the
Adam R. Lovato, Zeng Lin, Qingfei Zheng
wiley +1 more source
A more unified picture for the thermodynamics of nucleic acid duplex melting: A characterization by calorimetric and volumetric techniques [PDF]
, 1999 Tigran V. Chalikian +3 more
openalex +1 more source
Synthesis and Incorporation of a pH‐Responsive Nucleoside Into DNA Sequences
ChemBioChem, EarlyView.A pH‐responsive nucleoside is developed that enables a reversible switch in DNA between paired and unpaired states near physiological pH. This design may provide the framework for sequence‐independent, pH programable DNA motifs, thus paving the way for dynamic DNA nanotechnology applications.
Eric Ogel, Sidney Becker
wiley +1 more source
What Controls the Hybridization Thermodynamics of Spherical Nucleic Acids? [PDF]
, 2015 Pratik S. Randeria +6 more
openalex +1 more source
Chemistry – A European Journal, EarlyView.Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley +1 more source
Chemistry – A European Journal, EarlyView.Tetrapentylammonium forms a stable complex with c‐MYC G‐quadruplex, in which the ligand is positioned above the terminal G9‐G13‐G18‐G22 quartet of the host structure and is surrounded by the 3'‐(T23‐A24‐A25) flanking region. The binding proceeds with the release of waters of hydration and a slight decrease in the dynamics of the G‐quadruplex.
Xuan Li +4 more
wiley +1 more source
ChemMedChem, EarlyView.Sticky end‐type antithrombin aptamer, composed of two short hybridizable segments, is developed as a potential alternative to conventional anticoagulant drugs. The obtained bivalent aptamer surpasses existing long bivalent aptamers in anticoagulant activity and serum stability, offering advantages in synthesis efficiency and cost‐effectiveness. Aptamer
Maasa Yokomori +4 more
wiley +1 more source
Mechanically Tunable DNA Hydrogels as Prospective Biosensing Modules
Macromolecular Rapid Communications, EarlyView.Sequence‐programmable and thermally responsive DNA hydrogels enable highly sensitive mechanical biosensing through the exchange of linker strands using a toehold strand displacement mechanism. This new type of mechanical biosensor has in‐built sequence‐specificity and dose‐sensitivity, obviating the need for elaborate DNA sequencing and enabling rapid ...
Asya E. Can +4 more
wiley +1 more source
Synthesis and Characterization of Polynorbornenes with Nitronaphthyl Side‐Chains
Macromolecular Rapid Communications, EarlyView.Fluorescent polynorbornenes incorporating naphthyl ester side‐chains with various degrees of nitration are synthesized by ring‐opening metathesis polymerization. Their potential for the quantitative detection of electron‐rich aromatic compounds is demonstrated.
Gero Bramlage +2 more
wiley +1 more source
Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry
Mass Spectrometry Reviews, EarlyView.ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui +4 more
wiley +1 more source