Results 121 to 130 of about 34,544 (276)
Photopharmacology beyond azobenzene photoswitches
Responsive Materials, EarlyView.Photopharmacology is advancing beyond traditional azobenzene photoswitches by developing new photoresponsive molecules with improved thermal stability, efficiency, and long‐wavelength activation, enhancing their potential for precise biomedical applications.
Huichao Guo +5 more
wiley +1 more source
Small, EarlyView.IGA3, a guanine‐rich insulin aptamer, adopts different structures depending on environmental conditions. Under low cation concentrations, IGA3 forms a non‐G‐quadruplex structure that interacts with insulin. This finding highlights that guanine‐rich nucleic acids, in structures other than G‐quadruplex, can also bind to proteins, revealing valuable ...
Naoya Iwano +9 more
wiley +1 more source
Pleomorphism in Wild‐Type and Engineered PP7 Virus‐Like Particles
Small, EarlyView.Engineered virus‐like particles derived from the Pseudomonas‐infecting PP7 bacteriophage are examined by cryo electron microscopy, revealing a number of closed structures of different symmetry. The population distribution among these morphologies is determined as a function of the sequence and length of the peptide connector between coat protein ...
Parisa Keshavarz‐Joud +8 more
wiley +1 more source
From Sequence to Response: AI‐Guided Prediction of Nucleic Acid Nanoparticles Immune Recognitions
Small, EarlyView.We introduce a transformer‐based deep learning framework that predicts cytokine responses triggered by NANPs, enabling their rapid and scalable immune profiling through the A‐Icell web platform for therapeutic design and optimization. Abstract Nucleic acid nanoparticles (NANPs) represent a versatile platform for drug delivery and modulation of ...
M. Brittany Johnson +12 more
wiley +1 more source
Small Science, EarlyView.This review highlights the advances in graphene liquid cell designs for in situ liquid‐phase transmission electron microscopy, spanning veil‐type, well‐type, liquid‐flowing‐type, and mixing‐type configurations. These developments collectively enable real‐time visualization of diverse reactions in liquid environments at atomic resolution, thereby ...
Hyeonjong Ma +2 more
wiley +1 more source
Small Science, EarlyView.Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello +5 more
wiley +1 more source
Small Methods, EarlyView.This review provides key principles of designing and synthesizing reconfigurable plasmonic gold nanostructures for generating and controlling physical, chemical, and biological properties and functions. The recent advances in the biological and materials applications of dynamically reconfigurable plasmonic gold nanostructures are also summarized ...
So Young Choi +6 more
wiley +1 more source
Small Methods, EarlyView.Multiparametric analysis is a crucial aspect for enhancing the final sensitivity of biosensors based on organic transistors. The traditional approaches to treat the experimental data are not always suitable to extract the correct response. In this work EGOT characteristics are processed to achieve enantiodiscrimination of free Tryptophan enantiomers ...
Matteo Genitoni +9 more
wiley +1 more source
Small Structures, EarlyView.The review comprehensively summarizes the binding behaviors and multidimensional applications of malachite green with diverse functional nucleic acids. By integrating structural mechanisms, comparative analysis, and application strategies across eight domains, it provides theoretical guidance and future perspectives for developing intelligent nucleic ...
Keren Chen +4 more
wiley +1 more source