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Thermodynamic study of hybridization properties of heterochiral nucleic acids
Biochemical and Biophysical Research Communications, 2003Heterochiral DNA and RNA heptamers, which contained an unnatural L-nucleotide, were synthesized, and thermodynamic analyses of their hybridization properties with complementary DNA and RNA strands were systematically conducted by UV melting experiments.
Hidehito, Urata +4 more
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Computer Methods and Programs in Biomedicine, 2013
Proper design of nucleic acid sequences is crucial for many applications. We have previously established a thermodynamics-based quantitative model to help design aptamer-based nucleic acid probes by predicting equilibrium concentrations of all interacting species.
Jiaqi, Zou, Na, Li
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Proper design of nucleic acid sequences is crucial for many applications. We have previously established a thermodynamics-based quantitative model to help design aptamer-based nucleic acid probes by predicting equilibrium concentrations of all interacting species.
Jiaqi, Zou, Na, Li
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A Mathematical Model of Nucleic Acid Thermodynamics
2018The DNA denaturation, the double-stranded DNA unwinding process, is a vital process for cells. The percentage of the denaturation is used as an index of organism complexity and it is the base of the DNA hybridisation technique, which provides a great deal of information.
Sonia Guarguagli, Franco Pastrone
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A Spectroscopic and Thermodynamic Study of Taxol Nucleic Acid Complexes
Nucleosides and Nucleotides, 1999The interactions of natural and synthetic polynucleotide double strands with the antitumor agent paclitaxel and the oncological product "Taxol for Injection Concentrate" (abbreviated as taxol) were examined in diluted aqueous solutions by thermal denaturation profiles (Tm), CD spectra and UV-absorption measurements.
G, Bischoff +4 more
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Kinetic and Thermodynamic Origins of Osmolyte-Influenced Nucleic Acid Folding
The Journal of Physical Chemistry B, 2015The influential role of monovalent and divalent metal cations in facilitating conformational transitions in both RNA and DNA has been a target of intense biophysical research efforts. However, organic neutrally charged cosolutes can also significantly alter nucleic acid conformational transitions.
Erik D, Holmstrom +2 more
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Pyrene‐Modified Unlocked Nucleic Acids: Synthesis, Thermodynamic Studies, and Fluorescent Properties
ChemBioChem, 2012AbstractTwo pyrene‐modified UNA monomers were synthesized and incorporated into 21‐mer DNA oligonucleotides. Melting temperatures and thermodynamic properties of the modified duplexes were measured, and the fluorescence properties of single strands and duplexes containing one or more pyrene‐UNA modifications were studied.
Karlsen, Kasper K +3 more
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Synthesis and thermodynamics of peptide nucleic acid-conjugates
2023Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Molecular Sciences, Faculty of Science Technology and Engineering, La Trobe University, Bundoora.
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THERMODYNAMIC PROFILE OF INTERACTION OF PORPHYRINS WITH NUCLEIC ACIDS
2007The binding of a number of novel water soluble porphyrins to nucleic acids (NA) were studied monitoring the changes in Soret region of absorbance spectra, fluorescence spectra and circular dichroism (CD) spectra of formed complexes. The binding modes for all complexes were dtermined. The binding isotherms were used to calculate the binding constant, Kb,
Samvel Haroutiunian +3 more
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[Thermodynamic models of binding ligands to nucleic acids].
Biofizika, 2004Models of adsorption were considered, which describe the binding of biologically active ligands on DNA templates. The binding is described most comprehensively and in greatest detail by the distribution function, which determines the probability of detecting the preset number of adsorbed ligands on the template.
Iu D, Nechipurenko, G V, Gurskii
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Thermodynamics of Nucleic Acids Enclosed in Reverse Phase Vesicles
1984Reverse micelles and vesicles mimic properties of biological membranes in the sense that they include a small water volume in a charged or in an at least polar surface formed by the hydrophilic headgroups of amphiphilic compounds. Membranes with this type of a surface form the cellular compartments which are the reaction vessels for most chemical ...
Bernhard Brosius +3 more
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