DeepPNI: a language- and graph-based model for mutation-driven protein-nucleic acid binding energetics. [PDF]
Nucleic Acids ResMondal S, Mondal T, Pramanik S, Mehra R.
europepmc +1 more source
Nonthermal plasma approaches for combating implant‐associated infections: A compendious review
VIEW, EarlyView.Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe +8 more
wiley +1 more source
Mapping subcellular microenvironments using oligonucleotide-directed proximity labeling. [PDF]
Curr Opin Chem BiolSchactler SA +4 more
europepmc +1 more source
Thermodynamic Analysis of Nucleic Acid Aptamers Binding to Their Targets
Netsu Sokutei, 2023 Yamagishi, Kenji, Sakamoto, Taiichi
openaire +1 more source
Strategies for enhancing sensitivity in lateral flow assays
VIEW, EarlyView.Lateral flow assays (LFAs) are essential for cost‐effective, rapid point‐of‐care diagnostics. However, conventional colourimetric LFAs often lack the sensitivity required for low‐abundance biomarkers. This review evaluates six enhancement strategies: flow modulation, sample preconcentration, advanced reporters, chemical signal amplification, structural
Aylar Eslami Saed +3 more
wiley +1 more source
Biopolymer‐Based Polyelectrolyte Nanoplatforms for Targeted Photodynamic Therapy of Breast Cancer
VIEW, EarlyView.Illustration of the synthesis of 5‐aminolevulinic acid loaded chitosan‐sericin polyelectrolyte nanoparticles (CSSN/ALA NPs) using the Flash nanocomplexation (FNC) technique and their potential in photodynamic therapy (PDT) against breast cancer (BC). Abstract Nanomedicine has reshaped healthcare, especially in targeted drug delivery systems (DDSs) and ...
Athira Narayanan +14 more
wiley +1 more source
Demand-only energetics at 120 ATP per glucose: A reply to Lynch. [PDF]
Biochim Biophys Acta BioenergMartin WF.
europepmc +1 more source
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source
Sequence-Encoded Frustration Directs the Formation of Abridged G-Quadruplex Architectures. [PDF]
Angew Chem Int Ed EnglQian Y +6 more
europepmc +1 more source
KU80 suppresses endonuclease G activity to preserve genomic integrity
The FEBS Journal, EarlyView.Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan +8 more
wiley +1 more source