Results 161 to 170 of about 2,687,425 (254)

From rules to foundation models: a comprehensive review of machine learning approaches for siRNA design. [PDF]

NAR Genom Bioinform
Khodagholi Z, Yousefi N.
europepmc   +1 more source

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam, Michelle Khai Khun Yap, Rafael Giacomazzi, Sérgio F. Sousa, Hock Siew Tan   +4 more
wiley   +1 more source

Non-Viral Nanovectors Based on Cyclodextrins for siRNA Delivery: An Update to Current Technologies. [PDF]

Pharmaceutics
Chiarugi I, Maestrelli F, Piomboni G, Ristori S, Bilia AR.   +4 more
europepmc   +1 more source

3PA120 Thermodynamic Database for Protein-Nucleic Acid Interactions

Seibutsu Butsuri, 1999
P. Prabakaran, J. An, M. M. Gomiha, H. Uedaira, H. Kono, A. Sarai   +5 more
openaire   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Unraveling the Mechanism of Drug Binding to SARS-CoV-2 RNA Pseudoknot With Thermodynamics-Driven Machine Learning. [PDF]

J Comput Chem
Ivonina M, Rydzewski J.
europepmc   +1 more source

Thermodynamic factors in the synthesis of two-stranded nucleic acids. [PDF]

Proceedings of the National Academy of Sciences, 1966
openaire   +2 more sources

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

Cyclic transformation of stable/metastable nucleic acid structures enables dynamic monitoring of ATP in living cells. [PDF]

Chem Sci
Su ML, Yang J, Yang WG, Ye ZX, Wang RW, Qin JM, Song DQ, Yuan R, Ma PY, Zhuo Y, Yang C, Liang WB.   +11 more
europepmc   +1 more source

RNA activation in insects: From emerging evidence to molecular applications

Insect Molecular Biology, EarlyView.
Canonical RNA activation involves small RNAs interacting with promoter sequences, but there is also evidence of non‐canonical RNAa in eukaryotes. Emerging evidence suggests the presence of RNAa in insects. RNAa can be utilised as a tool for functional genomic studies in insects.
Sassan Asgari
wiley   +1 more source