Results 181 to 190 of about 2,687,425 (254)

Incorporation of Natural Antimicrobial Agents Into Thermoplastic Polymers for Food Applications: Strategies, Efficacy, Challenges and Future Directions

Packaging Technology and Science, Volume 39, Issue 10, Page 1253-1279, October 2026.
This graphical abstract summarizes the main strategies for incorporating natural antimicrobial agents into thermoplastic food packaging polymers, including melt processing, surface deposition, controlled release and chemical immobilization. It highlights the major classes of natural antimicrobials, key advantages such as microbial growth reduction and ...
Florence Akinmeye, Fabrice Gouanve, Fatima Zahra Jamal, Abdelkader Selmi, Sami Ghnimi   +4 more
wiley   +1 more source

Assessing Molecular Dynamics in Predicting Aptamer-Ligand Binding Thermodynamics: Insights from the OTA Binding Aptamers. [PDF]

J Chem Inf Model
Olivieri A, Borzelli F, Giustini M, D'Abramo M.   +3 more
europepmc   +1 more source

A Graph‐Based Machine Learning Framework to Assign Empirical Interaction Parameters for Novel Molecules

Journal of Computational Chemistry, Volume 47, Issue 24, September 15, 2026.
Quantum chemical methods of force field parameterization such as the Seminario method encountercompute limitations at large scales. We present a GNN framework that outperforms the Seminario method by 34% in reproducing infrared bond frequencies across prevalent functional groups, and is up to seven orders of magnitude faster on larger molecules ...
Yao Fu, Martin Stroet, Megan L. O'Mara
wiley   +1 more source

Theoretical Modeling of the Redox Thermodynamics of Nucleic Acid Building Blocks in the Condensed Phase. [PDF]

J Phys Chem B
Olivieri A, Nardi AN, D'Abramo M.
europepmc   +1 more source

Sodium Channel Blockers Demonstrate Binding Affinity for the Tandem Tudor Domain of the Epigenetic Hub UHRF1

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
An investigation of the tandem Tudor domain (TTD) domain of UHRF1 identified and extensively characterized the local anesthetic hydroxyprocaine as a strong ligand capable of activating related genes such as p53 and also highlighted a new, potentially druggable intramolecular interaction between TTD and UBL.
Efstratios Tsakalidis, Mariangela Giannouli, Ifigeneia Akrani, Anthi Panara, Eleni Katalagarianou, Kyriaki Degaita, Maria Giahou, Konstantina Kyriakou, Maria Routsi, Panagiota Efstathia Nikolaou, Evangelia Tsitsou, Aggeliki Tsoka, Constantinos C. Vorgias, Emmanuel Mikros, Evangelos Gikas, Eleni K. Efthimiadou, Vassilios Myrianthopoulos   +16 more
wiley   +1 more source

Kinetics, thermodynamics, and mechanisms of PMO interactions from computational molecular modeling. [PDF]

Mol Ther Nucleic Acids
Chou Y, Novikov I, Pierson D, Marx KA, Chanda A, Barsegov V.   +5 more
europepmc   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, Volume 13, Issue 49, 3 September 2026.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Programmable PNA-nanoparticle hybrids as nanoscale recognition architectures for amplification-free nucleic acid recognition. [PDF]

Biosens Bioelectron
Natarajan S, Skrodzki D, Yennawar NH, Gershenson J, Pan D.   +4 more
europepmc   +1 more source

ProNIT: Thermodynamic Database for Protein-Nucleic Acid Interactions.

Seibutsu Butsuri, 2002
SARAI, Akinori, PRABAKARAN, Ponraj, GROMIHA, M. Michael, KITAJIMA, Kouji, UEDAIRA, Hatsuho   +4 more
openaire   +2 more sources

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source