On binding mechanism exploration of organic amphoteric dye Rhodamine B with natural polymeric DNA
Discover Materials, 2023 Nucleic acids, like DNA and RNA, are molecules that are present in any life form. Their most notable function is to encode biological information.
Senchumbeni Yanthan +1 more
doaj +1 more source
Design principles for ligand-sensing, conformation-switching ribozymes. [PDF]
PLoS Computational Biology, 2009 Nucleic acid sensor elements are proving increasingly useful in biotechnology and biomedical applications. A number of ligand-sensing, conformational-switching ribozymes (also known as allosteric ribozymes or aptazymes) have been generated by some ...
Xi Chen, Andrew D Ellington
doaj +1 more source
Hachimoji DNA and RNA: A genetic system with eight building blocks [PDF]
, 2019 Reported here are DNA and RNA-like systems built from eight (hachi-) nucleotide letters (-moji) that form four orthogonal pairs. This synthetic genetic biopolymer meets the structural requirements needed to support Darwinism, including a polyelectrolyte ...
Bates, Alison M. +15 more
core +1 more source
Physico-chemical foundations underpinning microarray and next-generation sequencing experiments [PDF]
, 2013 Hybridization of nucleic acids on solid surfaces is a key process involved in high-throughput technologies such as microarrays and, in some cases, next-generation sequencing (NGS).
A. Buhot +70 more
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Viral genome structures are optimal for capsid assembly
eLife, 2013 Understanding how virus capsids assemble around their nucleic acid (NA) genomes could promote efforts to block viral propagation or to reengineer capsids for gene therapy applications.
Jason D Perlmutter +2 more
doaj +1 more source
Study of E. coli Hfq's RNA annealing acceleration and duplex destabilization activities using substrates with different GC-contents [PDF]
, 2012 Folding of RNA molecules into their functional three-dimensional structures is often supported by RNA chaperones, some of which can catalyse the two elementary reactions helix disruption and helix formation.
Beich-Frandsen, Mads +6 more
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Binding of threading intercalator to nucleic acids: Thermodynamic analyses [PDF]
Nucleic Acids Symposium Series, 2002 The constant melting temperature upon the change in the oligonucleotide concentration showed that the oligonucleotide d(CGCTTTGCG) formed a intramolecular hairpin rather than a duplex with an internal loop. We examined the thermodynamic properties of the interaction between the threading intercalator, naphthalene diimides designated as NDI, and a ...
Hidetaka, Torigoe +5 more
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Nucleic acid-lipid membrane interactions studied by DSC
Journal of Pharmacy and Bioallied Sciences, 2011 The interactions of nucleic acids with lipid membranes are of great importance for biological mechanisms as well as for biotechnological applications in gene delivery and drug carriers. The optimization of liposomal vectors for clinical use is absolutely
Sarantis Giatrellis, George Nounesis
doaj +1 more source
The thermodynamic landscape of carbon redox biochemistry [PDF]
, 2018 Redox biochemistry plays a key role in the transduction of chemical energy in all living systems. Observed redox reactions in metabolic networks represent only a minuscule fraction of the space of all possible redox reactions.
Aspuru-Guzik, Alán +7 more
core +1 more source
Theory on the mechanism of DNA renaturation: Stochastic nucleation and zipping [PDF]
, 2015 Renaturation of complementary single strands of DNA is one of the important processes that requires better understanding in the view of molecular biology and biological physics.
Murugan, Rajamanickam +1 more
core +8 more sources