Results 21 to 30 of about 55,484 (212)
Molecular Dynamics Analysis of Biomolecular Systems Including Nucleic Acids [PDF]
arXiv, 2021 Along with recent progress in structural biology and genome biology, structural dynamics of molecular systems including nucleic acids has attracted attention in the context of gene regulation. Structure-function relationship is an important topic, where physicochemical properties of nucleotides are important as well as those of amino acids in proteins.
arxiv
A Theoretical Mechanism of Szilard Engine Function in Nucleic Acids and the Implications for Quantum Coherence in Biological Systems [PDF]
AIP Conf. Proc. 1316, July 2010, pp. 287-290, 2012 Nucleic acids theoretically possess a Szilard engine function that can convert the energy associated with the Shannon entropy of molecules for which they have coded recognition, into the useful work of geometric reconfiguration of the nucleic acid molecule.
arxiv +1 more source
Modified RNA triplexes: Thermodynamics, structure and biological potential
Scientific Reports, 2018 The occurrence of triplexes in vivo has been well documented and is determined by the presence of long homopurine-homopyrimidine tracts. The formation of these structures is the result of conformational changes that occur in the duplex, which allow the ...
Marta Szabat +2 more
doaj +1 more source
Nanosecond chain dynamics of single-stranded nucleic acids [PDF]
arXiv, 2023 The conformational dynamics of single-stranded nucleic acids are fundamental for nucleic acid folding and function. However, their elementary chain dynamics have been difficult to resolve experimentally. Here we employ a combination of single-molecule F\"orster resonance energy transfer, nanosecond fluorescence correlation spectroscopy, fluorescence ...
arxiv
Framework nucleic acids directed assembly of Au nanostructures for biomedical applications
Interdisciplinary Medicine, Volume 1, Issue 1, January 2023., 2023 This Review article discusses the advanced progress in the Au and DNA nanomaterials. Introduced by the latest advances in frame nucleic acids‐detected Au nanostructures, the biomedical applications including biosensing and therapeutics are explored.
Bing Liu, Zhonglin Qi, Jie Chao
wiley +1 more source
Solution of the Crow-Kimura and Eigen models for alphabets of arbitrary size by Schwinger spin coherent states [PDF]
, 2009 To represent the evolution of nucleic acid and protein sequence, we express the parallel and Eigen models for molecular evolution in terms of a functional integral representation with an $h$-letter alphabet, lifting the two-state, purine/pyrimidine assumption often made in quasi-species theory. For arbitrary $h$ and a general mutation scheme, we obtain
arxiv +1 more source
Ab Initio Nucleic Acid Folding Simulations Using a Physics-Based Atomistic Free Energy Model [PDF]
, 2022 Performing full-resolution atomistic simulations of nucleic acid folding has remained a challenge for biomolecular modeling. Understanding how nucleic acids fold and how they transition between different folded structures as they unfold and refold has important implications for biology.
arxiv +1 more source
Artificial Receptor in Synthetic Cells Performs Transmembrane Activation of Proteolysis
Advanced Biology, EarlyView.Transmembrane signaling is the hallmark of living cells and is among the highest challenges for the design of synthetic cells. Herein, an artificial receptor based on the chemistry of self‐immolative linkers is used to communicate information across the lipid bilayer, for transmembrane activation of enzymatic activity. Abstract The design of artificial,
Ane Bretschneider Søgaard +7 more
wiley +1 more source
Controlling Size and Surface Chemistry of Cationic Nanogels by Inverse Microemulsion ATRP
Macromolecular Chemistry and Physics, Volume 224, Issue 1, January 2023., 2023 Cationic nanogels are prepared by atom transfer radical polymerization (ATRP) under inverse microemulsion conditions of a hydrophilic inimer that prevents monomer diffusion and hence limits droplets’ growth during polymerization. The surface functionality of the nanogels is modulated by the application of hydrophobic reactive surfactants or grafting ...
Antonina Simakova +3 more
wiley +1 more source
HiTRACE: High-throughput robust analysis for capillary electrophoresis [PDF]
, 2011 Motivation: Capillary electrophoresis (CE) of nucleic acids is a workhorse technology underlying high-throughput genome analysis and large-scale chemical mapping for nucleic acid structural inference. Despite the wide availability of CE-based instruments, there remain challenges in leveraging their full power for quantitative analysis of RNA and DNA ...
arxiv +1 more source